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Journal of the American Society of Nephrology
Scopus
ISSN 1046-6673 · American Society of Nephrology · 24 artikel di indeks
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Artikel Jurnal
Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology
Significance Statement Although corticosteroids are an effective first-line therapy for minimal change disease, relapse, steroid dependence, and intolerance are common in this podocytopathy of unknown etiology. The efficacy of B cell–targeted therapies in some patients suggests an…
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Artikel Jurnal
A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease
Significance Statement A Task Force from the National Kidney Foundation and American Society of Nephrology developed recommendations for reassessing inclusion of race in the estimation of GFR in the United States. The Task Force recommends immediate implementation of the Chronic Kidney Disease…
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Artikel Jurnal
Kidney Outcomes in Long COVID
Significance Statement Patients who survive coronavirus disease 2019 (COVID-19) are at higher risk of post-acute sequelae involving pulmonary and several extrapulmonary organ systems—generally referred to as long COVID. However, a detailed assessment of kidney outcomes in long COVID is not yet…
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Artikel Jurnal
Rituximab or Cyclophosphamide in the Treatment of Membranous Nephropathy: The RI-CYCLO Randomized Trial
Significance Statement A cyclic regimen of corticosteroid and cyclophosphamide is the first-line therapy for membranous nephropathy. Rituximab is superior to conservative treatment and noninferior to cyclosporine in inducing remission; it also may have a more favorable safety profile compared with…
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Artikel Jurnal Teks lengkap
Hyperkalemia Risk with Finerenone: Results from the FIDELIO-DKD Trial
Significance Statement Hyperkalemia is common after treatment with a mineralocorticoid receptor antagonist (MRA). In the FIDELIO-DKD randomized trial, the nonsteroidal MRA finerenone improved cardiorenal outcomes, but was associated with a twofold higher risk of hyperkalemia versus placebo…
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Artikel Jurnal
Clinical Features and Outcomes of Immune Checkpoint Inhibitor–Associated AKI: A Multicenter Study
Significance Statement Kidney toxicity from use of immune checkpoint inhibitors is being recognized as an increasingly frequent complication of treatment. However, existing data on immune checkpoint inhibitor–associated AKI have been limited to small, mostly single-center studies. In this…
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Artikel Jurnal
AKI in Hospitalized Patients with and without COVID-19: A Comparison Study
Significance Statement Centers have reported a wide range of AKI incidence rates among patients hospitalized with coronavirus disease 2019 (COVID-19). In a retrospective observational study, the authors compared the incidence, risk factors, and outcomes of AKI in hospitalized adults with and…
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Artikel Jurnal
AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL 1 High-Risk Genotype
Significance Statement Kidney involvement may occur in coronavirus disease 2019 (COVID-19), and can be severe among Black individuals. In this study of collapsing glomerulopathy in six Black patients with COVID-19, the authors found that all six had variants in the gene encoding apo L1 (APOL1) that…
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Artikel Jurnal
Postmortem Kidney Pathology Findings in Patients with COVID-19
Significance Statement More than one third of hospitalized patients with coronavirus disease 2019 (COVID-19) develop AKI. The pathogenesis of AKI in this setting is poorly understood, and pathologic descriptions are limited. The authors examined kidney histopathology of 42 patients who died of…
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Artikel Jurnal
AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19
Significance Statement Although AKI is an important sequela of coronavirus disease 2019 (COVID-19), data on AKI treated with RRT (AKI-RRT) in patients with COVID-19 are limited. In a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units (ICUs) at 67…
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Artikel Jurnal
Kidney Biopsy Findings in Patients with COVID-19
Significance Statement The mechanisms underlying coronavirus disease 2019 (COVID-19)–associated kidney injury are unknown, and morphologic correlates are few and limited to patient reports or autopsy series. The authors’ evaluation of a biopsy series of 14 native and 3 allograft kidneys from…
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Artikel Jurnal
The Effects of High-Protein Diets on Kidney Health and Longevity
Although high-protein diets continue to be popular for weight loss and type 2 diabetes, evidence suggests that worsening renal function may occur in individuals with—and perhaps without—impaired kidney function. High dietary protein intake can cause intraglomerular hypertension, which may result in…
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Artikel Jurnal
Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid–Mediated Activation of G Protein–Coupled Receptors GPR43 and GPR109A
Significance Statement The gut microbiota and its metabolites, in particular short-chain fatty acids derived from gut microbes’ fermentation of fiber, are emerging therapeutic targets for systemic inflammatory and metabolic diseases, including diabetic nephropathy. The authors report that…
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Artikel Jurnal
Presentation and Outcomes of Patients with ESKD and COVID-19
Significance Statement Immunosuppression and a high prevalence of comorbidities among patients with ESKD on dialysis raise concerns that such patients may have an elevated risk of severe coronavirus disease 2019 (COVID-19). However, the outcomes for COVID-19 in this patient population are not…
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Artikel Jurnal
COVID-19–Associated Kidney Injury: A Case Series of Kidney Biopsy Findings
Significance Statement AKI is a known complication of severe COVID-19. Autopsy series of patients who died with COVID-19 reported acute tubular necrosis in the kidney, and a few patient reports noted the presence of collapsing glomerulopathy in patients with COVID-19. The authors describe clinical…
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Artikel Jurnal
Ultrastructural Evidence for Direct Renal Infection with SARS-CoV-2
Significance Statement The cause of kidney injury in COVID-19 is unclear. In an autopsy study of a single patient with COVID-19 and acute oliguric renal failure, the authors identified intracellular viral arrays within proximal tubular epithelial cells by electron microscopy, consistent with direct…
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Artikel Jurnal
Clinical Characteristics of and Medical Interventions for COVID-19 in Hemodialysis Patients in Wuhan, China
Significance Statement Although reports indicate that patients receiving maintenance hemodialysis are at risk for severe illness with coronavirus disease 2019 (COVID-19), information about this population of patients is limited. Using data retrospectively collected from a registration system that…
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Artikel Jurnal
Iron Deficiency in Chronic Kidney Disease: Updates on Pathophysiology, Diagnosis, and Treatment
Anemia is a complication that affects a majority of individuals with advanced CKD. Although relative deficiency of erythropoietin production is the major driver of anemia in CKD, iron deficiency stands out among the mechanisms contributing to the impaired erythropoiesis in the setting of reduced…
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Artikel Jurnal
Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia
Significance Statement Some cases of COVID-19 pneumonia have presented with kidney injury, and autopsy findings for patients with COVID-19 have revealed renal involvement. In this retrospective, single-center study of Chinese patients with COVID-19 pneumonia, 251 of 333 patients (75.4%) presented…
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Artikel Jurnal
Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology
The most common reported reasons for intensive care unit admission for patients with severe coronavirus disease 2019 (COVID-19) are either hypoxemic respiratory failure leading to mechanical ventilation or hypotension requiring vasopressor support. Data on AKI are either lacking1 or only reporting…