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American Journal of Respiratory and Critical Care Medicine
Scopus
ISSN 1073-449X · American Thoracic Society · 59 articles in the index
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Race and Ethnicity in Pulmonary Function Test Interpretation: An Official American Thoracic Society Statement
Current American Thoracic Society (ATS) standards promote the use of race and ethnicity-specific reference equations for pulmonary function test (PFT) interpretation. There is rising concern that the use of race and ethnicity in PFT interpretation contributes to a false view of fixed differences…
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An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline
Abstract Background This document updates previously published Clinical Practice Guidelines for the management of patients with acute respiratory distress syndrome (ARDS), incorporating new evidence addressing the use of corticosteroids, venovenous extracorporeal membrane oxygenation, neuromuscular…
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Pulmonary Rehabilitation for Adults with Chronic Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline
Abstract Background Despite the known benefits of pulmonary rehabilitation (PR) for patients with chronic respiratory disease, this treatment is underused. Evidence-based guidelines should lead to greater knowledge of the proven benefits of PR, highlight the role of PR in evidence-based health…
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Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published the complete 2023 GOLD report, which can be freely downloaded from its web page (www.goldcopd.org) together with a“pocket guide” and a “teaching slide set”. It contains important changes compared to earlier versions…
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A New Global Definition of Acute Respiratory Distress Syndrome
Abstract Background Since publication of the 2012 Berlin definition of acute respiratory distress syndrome (ARDS), several developments have supported the need for an expansion of the definition, including the use of high-flow nasal oxygen, the expansion of the use of pulse oximetry in place of…
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The Bidirectional Gut–Lung Axis in Chronic Obstructive Pulmonary Disease
Abstract Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one of the major causes of COPD, can have an impact on the gastrointestinal system and promotes intestinal diseases…
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Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Abstract Background This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of pulmonary fibrosis in patients with…
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Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision
Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years ago, when he proposed that a definition should state the essential nature or being of something (1). However, this abstract concept (2–4) may not translate well to medical practice, where precise…
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Characterization of Eosinophilic Bronchiectasis: A European Multicohort Study
Abstract Rationale Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic subtypes have recently been described. Objectives To use multiple datasets available through the European Multicentre Bronchiectasis Audit and Research Collaboration to characterize eosinophilic…
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Syndrome of Combined Pulmonary Fibrosis and Emphysema: An Official ATS/ERS/JRS/ALAT Research Statement
Abstract Background The presence of emphysema is relatively common in patients with fibrotic interstitial lung disease. This has been designated combined pulmonary fibrosis and emphysema (CPFE). The lack of consensus over definitions and diagnostic criteria has limited CPFE research. Goals The…
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Ventilatory Variables and Mechanical Power in Patients with Acute Respiratory Distress Syndrome
Abstract Rationale Mortality in acute respiratory distress syndrome (ARDS) has decreased after the adoption of lung-protective strategies. Lower Vt, lower driving pressure (ΔP), lower respiratory rates (RR), and higher end-expiratory pressure have all been suggested as key components of lung…
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Clinical Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in People with Cystic Fibrosis: A Clinical Trial
Abstract Rationale The cystic fibrosis (CF) modulator drug, elexacaftor/tezacaftor/ivacaftor (ETI), proved highly effective in controlled clinical trials for individuals with at least one F508del allele, which occurs in at least 85% of people with CF. Objectives PROMISE is a postapproval study to…
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An Updated Definition and Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbations: The Rome Proposal
Over 200 years ago, René Laennec published the first description of emphysema, an important pathobiological element of what is today known as chronic obstructive pulmonary disease (COPD) (1). He stated that the disease was characterized by persistent dyspnea punctuated by acute episodes of…
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Latent Class Analysis Reveals COVID-19–related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids
Abstract Rationale Two distinct subphenotypes have been identified in acute respiratory distress syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus disease (COVID-19) is unknown. Objectives To identify clinically relevant, novel subgroups in COVID-19–related ARDS and…
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A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One F508del Allele
Abstract Rationale Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be efficacious and safe in patients ≥12 years of age with cystic fibrosis and at least one F508del-CFTR (cystic fibrosis transmembrane conductance regulator) allele, but it has not been evaluated in children
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Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes
Abstract The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually updated evidence-based strategy for asthma management and prevention, which can be adapted for local circumstances (e.g., medication availability). This article summarizes key recommendations from…
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Pulmonary Arterial Hypertension: Diagnosis, Treatment, and Novel Advances
The diagnosis and management of pulmonary arterial hypertension (PAH) includes several advances, such as a broader recognition of extrapulmonary vascular organ system involvement, validated point-of-care clinical assessment tools, and focus on the early initiation of multiple pharmacotherapeutics…
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Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study
To the Editor:Five to twenty percent of hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are admitted to the ICU, with mortality reported between 26% and 61.5% (1-3).Nearly all ICU patients present with respiratory failure, and up to 88% are managed…
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Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2
declared the coronavirus disease (COVID-19) outbreak a pandemic.As of May 28, 2020, laboratories had confirmed 5,701,337 COVID-19 cases, and 357,668 deaths had been reported in 216 countries, areas, or territories (1).COVID-19 is caused by a new type of pathogenic coronavirus, severe acute…
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Journal Article
COVID-19–associated Pulmonary Aspergillosis
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