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Neurobiology of Disease
Scopus
ISSN 1095-953X · Elsevier · 7.065 artikel di indeks
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Artikel Jurnal
Functional Reelin signaling deficits without interneuron loss are associated with neuroblast misplacement after non-convulsive status epilepticus
Non-convulsive status epilepticus (NCSE) accounts for 20 to 40% of all observed cases of status epilepticus in the intensive care unit, but its early cellular and molecular consequences remain poorly understood. Here, we investigated early dentate gyrus alterations after pilocarpine-induced NCSE…
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PrPC limits APP delivery to the plasma membrane and alters its processing to facilitate Aβ release
Several lines of evidence suggest that the cellular isoform of prion protein (PrPC) plays one or more roles in Alzheimer's Disease (AD). We previously found, in mouse neuroblastoma N2a cells that express human APP carrying the Swedish mutation (N2a-APPswe), that PrPC expression correlated with the…
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Integrative transcriptomic meta-analysis reveals immune, synaptic, and non-coding RNA dysregulation in bipolar disorder across brain and blood
Introduction: Bipolar disorder (BD) is a major psychiatric illness with a high global burden, unclear pathophysiology, and limited biological markers, leaving diagnosis reliant on behavioral criteria. While there is an increasing number of individual transcriptomic studies investigating genes…
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Linking subjective cognitive decline to glymphatic dysfunction in Parkinson's disease
Background: The role of glymphatic system in the subjective cognitive decline (SCD) stage of Parkinson's disease (PD) remains unexplored. This study investigated whether glymphatic dysfunction occurs in PD-SCD and its potential role in mediating the link between sleep disturbance and cognitive…
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Artikel Jurnal
SGK1 inhibition restores excitability of cortical neurons derived from Alzheimer's disease patients
The vast majority of Alzheimer's disease (AD) cases are sporadic, without a clear etiology. We have previously found increased expression of Serum and Glucocorticoid-regulated Kinase 1 (SGK1) in mouse models of dementia, postmortem cortical tissues and induced pluripotent stem cells (iPSCs)-derived…
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Artikel Jurnal
Differences in white matter detected by ex vivo 9.4 T MRI are associated with axonal changes in the R6/1 model of Huntington's disease
White matter volume loss has been reported as one of the first indicators in Huntington's disease (HD) patients, but the cellular basis of this deficit remains to be elucidated. To address this, we assessed white matter microstructure in the transgenic R6/1 mouse model of HD with ex vivo MRI…
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Cholinergic neurotransmission underlying visual hallucinations in Parkinson's disease: Integration of multimodal evidence and translational approaches
Visual hallucinations (VH) represent a prevalent and clinically significant non-motor manifestation in Parkinson’s disease (PD), often leading to accelerated cognitive decline, increased caregiver burden, and reduced quality of life. Despite their impact, the neurobiological basis of VH remains…
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Artikel Jurnal
The neuropathological mechanisms underlying the inborn errors of lysine metabolism
Optimal lysine catabolism is essential for the proper growth and development of mammals. Lysine is degraded through either the saccharopine or pipecolate pathway, processes characterized by distinct tissue specificity and subcellular compartmentalization. Although controversy persists, accumulating…
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Stathmin 1 regulates epileptic seizures by influencing GABAA R-mediated inhibitory synaptic activity
Epilepsy is a common neurological disease, and approximately 30% of patients with epilepsy do not respond adequately to antiseizure medications. STMN1 (Stathmin 1) is a potent regulator of microtubule stability, and previous research has shown that STMN1 expression is increased in epileptic brain…
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Artikel Jurnal
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results in paralysis and death within three to five years. Mutations in over forty different proteins have been linked to ALS, raising debate over whether ALS is a single disease or multiple disorders with similar…
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Artikel Jurnal
Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema
Volume-regulated anion channels (VRACs) are central to cell volume homeostasis. They mediate swelling-induced efflux of chloride and organic osmolytes to drive regulatory volume decrease. In the brain, VRACs have been proposed to play a key role in astrocytic volume regulation. Genetic defects in…
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Artikel Jurnal
Glymphatic dysfunction in trigeminal neuralgia: A multimodal MRI study
Background: Trigeminal neuralgia (TN) has traditionally been attributed to peripheral neurovascular compression at the trigeminal nerve root entry zone. Recent evidence, however, suggests central mechanisms may contribute to disease pathogenesis. We investigated whether glymphatic system…
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Artikel Jurnal
A neuropeptide receptor–enriched transcriptional state characterizes resilient dopaminergic neurons in Parkinson's disease
Dopaminergic neurons (DANs) exhibit subtype-specific vulnerability in Parkinson's disease (PD), but the molecular basis of selective resilience remains poorly understood. Here, we investigated the role of neuropeptide receptor (NPR) signaling in DAN survival using single-nucleus RNA sequencing of…
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Spinal cord reactive-antibodies identified by serological antigen selection show prognostic value in traumatic spinal cord injury patients
Outcome prediction after traumatic spinal cord injury (SCI) remains challenging due to patient heterogeneity, highlighting the need for better prognostic tools. Neural tissue damage and blood–spinal cord barrier disruption expose the immune system to spinal cord proteins, eliciting autoantibody…
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Artikel Jurnal
Artificial intelligence and machine learning in neurodegenerative disease management: A 21st century paradigm
Neurodegenerative diseases represent a major and growing clinical challenge due to their progressive nature, biological heterogeneity, and limited therapeutic options. Recent advances in artificial intelligence (AI) have introduced new analytical strategies for extracting clinically relevant…
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Artikel Jurnal
The HCF-1:OGT axis regulates neuronal proliferation and differentiation
Neuronal differentiation requires precise coordination of progenitor proliferation, lineage commitment, and chromatin regulation to establish functional brain architecture. Host Cell Factor-1 (HCF-1), an X-linked transcriptional co-regulator linked to human intellectual disability, is essential for…
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Artikel Jurnal
Hippocampal glial alterations are associated with Lamin B1 dysregulation and abnormal nuclear morphology in a rat model of fragile X syndrome
Fragile X syndrome (FXS) is the most common inherited intellectual disability and the leading monogenic cause of autism spectrum disorders (ASD). Although the pathological mechanisms underlying this neurodevelopmental disorder are challenging, recent studies have increasingly highlighted the…
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