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Infection and Immunity
Scopus
ISSN 1098-5522 · American Society for Microbiology · 332 artikel di indeks
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Artikel Jurnal
Underexplored maternal microbiomes: immune, metabolic, and microbial pathways shaping pregnancy outcomes
ABSTRACT Maternal microbial ecosystems play critical roles in shaping reproductive physiology and pregnancy outcomes. During the pre-conception and prenatal periods, these communities modulate maternal physiology by regulating immune tolerance, nutrient metabolism, and susceptibility to pregnancy…
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Artikel Jurnal
Strain-specific immune response patterns to Borrelia burgdorferi infection: a comparative transcriptomic analysis in C3H and C57BL/6 mice
ABSTRACT Borrelia burgdorferi (Bb), transmitted through tick vectors, induces Lyme arthritis (LA), with disease progression intimately correlated with host genetic characteristics. Laboratory investigations have demonstrated marked disparities in infection responses among distinct mouse strains…
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Artikel Jurnal
Orientia tsutsugamushi binds to multiple C-type lectin receptors
ABSTRACT Orientia tsutsugamushi, the agent of scrub typhus, is an obligate intracellular bacterium whose atypical cell wall lacks many classical pathogen-associated molecular patterns but is enriched in neutral glycans. Its recognition by phagocytes is driven by a heat-stable ligand that triggers…
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Artikel Jurnal
Connections between Klebsiella pneumoniae bloodstream dynamics and serotype-independent capsule properties
ABSTRACT Klebsiella pneumoniae bacteremia is a significant public health burden with a 26% mortality rate, which increases when the infecting isolate is multidrug resistant. An important virulence factor of K. pneumoniae is its capsule, the protective polysaccharide coat that surrounds the outer…
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Artikel Jurnal
Non-receptor tyrosine kinase c-Abl downstream of C-type lectin receptors regulates innate antifungal immunity through c-Cbl/MAPK pathway
ABSTRACT Non-receptor tyrosine kinase c-Abl is critical for host defense against bacterial and viral infections, yet its role in antifungal immunity remains elusive. Here, we report that inhibition of c-Abl with flumatinib mesylate significantly impairs the survival rate and exacerbates fungal…
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Artikel Jurnal
Comparative transcriptomics reveals genes commonly induced by distinct stressors in Chlamydia
ABSTRACT Chlamydia trachomatis is a leading cause of urogenital infections that can result in serious long-term complications. This obligate intracellular bacterium undergoes a biphasic developmental cycle alternating between the infectious elementary body and the replicative reticulate body and…
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Artikel Jurnal
METTL14/IGF2BP1 m6A axis promotes pyroptosis in Streptococcus pneumoniae-induced pneumonia by regulating NEK7 mRNA stability
ABSTRACT Streptococcus pneumoniae (S. pneumoniae) infection induces pyroptosis in human pulmonary artery epithelial cells (HPAEpiCs), which contributes to pneumonia pathogenesis. We aimed to investigate the regulatory role of N6-methyladenosine (m6A) modification mediated by methyltransferase-like…
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Artikel Jurnal
The L-lactate dehydrogenase LldD contributes to oxidative stress resistance, survival from neutrophils, and host colonization in Neisseria gonorrhoeae
ABSTRACT Metabolic adaptation to the host environment is a key determinant of bacterial pathogenesis, enabling both colonization and invasive disease. This is particularly true for Neisseria gonorrhoeae (Gc), the causative agent of gonorrhea, which lacks effector-injecting secretion systems or…
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Artikel Jurnal
Identification of novel pyrazolo[4,3-c]pyridine and diazepane derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), continues to pose a critical global health threat as a leading infectious cause of mortality. Therapeutic efficacy is increasingly compromised by the emergence of multidrug-resistant strains and the limitations of existing…
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Artikel Jurnal
The structure of Streptococcus gordonii surface protein SspB in complex with TEV peptide provides clues to oral streptococcal adherence to salivary agglutinin
ABSTRACT Streptococcus gordonii is a commensal bacterium in the oral cavity and has many surface adhesins that have been well characterized. SspA/B belongs to the Antigen I/II-like family of proteins, which are well known for their multifunctional adherence capabilities. Most AgI/II-like proteins…
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Artikel Jurnal
Mouse models of tuberculosis uniformly featuring hypoxic necrotic lesions and poor response to chemotherapy
ABSTRACT Mouse models have been key to studies of tuberculosis pathogenesis and drug efficacy, but many, such as those employing BALB/c mice, fail to reproduce the full range of heterogenous microniches observed in well-structured human lesions, which feature hypoxic caseous cores of necrotic…
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Artikel Jurnal
Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent Klebsiella pneumoniae
ABSTRACT Klebsiella pneumoniae is an opportunistic Gram-negative pathogen and a common cause of antibiotic-resistant infections including neonatal sepsis and hospital-acquired pneumonia. K. pneumoniae strains can be categorized into two pathotypes: classical K. pneumoniae (cKp), which often causes…
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Artikel Jurnal
Acquisition of toxin-encoding lysogenic bacteriophage elements enhances the virulence of pandemic Streptococcus pyogenes M1UK
ABSTRACT Multiple countries have observed an alarming increase in scarlet fever cases, and invasive infections often associated with a new sublineage of Streptococcus pyogenes known as M1UK. M1UK strains express increased levels of the streptococcal pyrogenic exotoxin A (SpeA) superantigen, and…
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Artikel Jurnal
Identification of collaborative cross mouse strains susceptible to chlamydial induction of hydrosalpinx
ABSTRACT Sexually transmitted infection with Chlamydia trachomatis can cause pathology, such as hydrosalpinx, in the upper genital tract, leading to infertility. To investigate how genetic variation affects chlamydial pathogenicity, we screened five strains of Collaborative Cross (CC) mice for…
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Artikel Jurnal
The Leptospira interrogans CdaA protein is a functional diadenylate cyclase
ABSTRACT Leptospirosis is a zoonotic disease that affects humans, companion animals, livestock, and wildlife. There are over 60 species that are established pathogens. Leptospires must rapidly adapt to changing environmental conditions as they pass between the environment and vertebrates…
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Artikel Jurnal
Extracellular vesicles of Emergomyces africanus modulate host immune responses and reflect metabolic adaptations to nutrient availability
ABSTRACT Emergomyces africanus is a thermal dimorphic fungus and a leading cause of emergomycosis, a neglected infection primarily affecting immunocompromised individuals. Despite its clinical relevance, little is known about how E. africanus adapts to the host environment. Recent studies suggest…
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Artikel Jurnal
Elevated vaginal heparan sulfate correlates with impaired neutrophil killing of Candida albicans in women with vulvovaginal candidiasis
ABSTRACT Recurrent vulvovaginal candidiasis (RVVC), primarily caused by the fungal pathogen Candida albicans, is a common infection affecting a significant number of women worldwide. Despite a robust inflammatory response by polymorphonuclear neutrophils (PMNs) with potent antifungal properties…
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Artikel Jurnal
A murine model of adult gastrointestinal colonization by Group B Streptococcus
ABSTRACT Group B Streptococcus (Streptococcus agalactiae, GBS) is a leading cause of invasive infections in neonates and adults. The adult gastrointestinal (GI) tract represents an understudied site of asymptomatic carriage with potential relevance for both transmission and disease. Here, we…
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Artikel Jurnal
Human immune response to primary cryptosporidiosis parallels murine infection models
ABSTRACT Cryptosporidium is a protozoan parasite that causes cryptosporidiosis, an enteric infection associated with diarrhea, malnutrition, and impaired childhood development in low- and middle-income countries. Both humoral and cell-mediated immune responses have been implicated in protection…
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Artikel Jurnal
Post-TB lung disease: pathogenesis, host-directed therapies, and the C3HeB/FeJ model for pre-clinical advances
ABSTRACT More than half of the people with microbiologically cured tuberculosis (TB) present with post-TB lung disease (PTLD). PTLD compromises long-term respiratory health and adds to the global burden of chronic lung diseases. Despite its prevalence, the mechanisms driving tissue damage in TB are…