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Journal of Bacteriology
Scopus
ISSN 1098-5530 · American Society for Microbiology · 426 articles in the index
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Journal Article
The Pseudomonas aeruginosa PrrF sRNAs and PqsA promote biofilm formation at body temperature
ABSTRACT Pseudomonas aeruginosa is a gram-negative opportunistic pathogen that causes both acute and chronic infections in vulnerable populations. Treatment of P. aeruginosa infections is increasingly challenging due to multi-drug resistance, and biofilm formation during infection further increases…
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Journal Article
CRISPR interference in a Streptococcus agalactiae multi-locus sequence type 17 strain
ABSTRACT Group B Streptococcus (GBS), a common colonizer of the human genital and gastrointestinal tracts, is a leading cause of neonatal bacterial meningitis, which can lead to severe neurological complications. The hypervirulent serotype III, sequence type 17 (ST-17) strain COH1 is strongly…
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Journal Article
Chemical-mediated alteration of antibiotic susceptibility: mechanisms and potential new targets for antibiotic adjuvant discovery
ABSTRACT The critical rise in antimicrobial resistance rates, coupled with a nearly stagnant drug discovery pipeline, has resulted in a sharp surge in clinical failure of antibiotic therapy. Antimicrobial resistance, possibly leading to therapeutic failures, has been predominantly attributed to…
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Journal Article
Norepinephrine derepresses the Fur regulon of Neisseria gonorrhoeae to enable growth in iron-limited conditions
ABSTRACT Neisseria gonorrhoeae (Gc) is the gram-negative bacterium that causes gonorrhea, a prevalent sexually transmitted infection that can have life-threatening clinical sequelae. Gc requires iron for human infection and uses the iron-responsive, iron-binding transcriptional repressor Fur to…
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Journal Article
YeiE regulates YeiH to implement sulfite stress resistance in Salmonella enterica serotype Typhimurium
ABSTRACT Sulfites are toxic, reactive sulfur species that are widespread in nature. Bacteria are exposed to sulfites during the metabolism of sulfur-containing amino acids, during respiration using sulfur-containing electron acceptors, in host environments, and as food preservatives. Despite the…
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Journal Article
Functional characterization of the polar organizer protein FimV in Pseudomonas putida
ABSTRACT Homologs of the polar landmark proteins HubP and FimV are widespread among bacterial species. They all share several common features, including a periplasmic LysM-like domain, a transmembrane region, an extensive cytoplasmic domain enriched in acidic amino acids, and a C-terminal…
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Journal Article
Role of Tad pili during the transition from planktonic to biofilm state in Bradyrhizobium diazoefficiens USDA 110
ABSTRACT Free-living soil bacteria can exist in two main states: planktonic, as motile single cells, or sessile, within biofilms. In biofilms, bacterial cells are embedded in an extracellular matrix that provides protection from environmental stresses and enhances long-term survival. The transition…
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Journal Article
The staphylococcal type VII secretion system protein EsxC impacts daptomycin sensitivity through controlling bacterial cell envelope integrity
ABSTRACT The human pathogen Staphylococcus aureus encodes a specialized type VII secretion system (T7SS), which plays an important role in bacterial virulence during infection. However, the functions of the T7SS during infection and in bacterial physiology remain unclear. Here, we demonstrate that…
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Journal Article
Managing dangerous liaisons: lessons from Helicobacter pylori for understanding bacterial carcinogenesis
ABSTRACT As the first bacterium to be deemed a class I carcinogen by the World Health Organization in 1994, Helicobacter pylori has paved the way for studying complex host-pathogen interactions. While 1982 marked the discovery of this helical-shaped microorganism found in gastric biopsies by Drs…
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Journal Article
Genus-specific remodeling of carbon and energy metabolism facilitates acetoclastic methanogenesis in Methanosarcina spp. and Methanothrix spp.
ABSTRACT Methanogenic archaea (methanogens) are microorganisms that obligately produce methane as a byproduct of their energy metabolism. While most methanogens grow on CO2+H2, isolates of the genera Methanosarcina and Methanothrix can use acetate as the sole substrate for methanogenesis…
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Journal Article
Unique metabolic traits of Pseudomonas bharatica CSV86T: a promising candidate for biodegradation and up-cycling of aromatics
ABSTRACT Pseudomonas spp. are ubiquitous, metabolically versatile bacteria that exhibit remarkable adaptability to thrive in diverse ecological niches contaminated with aromatics, such as pesticide-polluted agricultural soils, industrial wastewater, and lignin-based waste. This review highlights…
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Journal Article
Bacterial sensing and response for neutralization and detoxification of environmental ammonia
ABSTRACT Ammonia present in the environment is a major source of nitrogen, but it can be toxic to bacteria. While the biochemical mechanisms involved in the metabolic detoxification of cellular ammonia are well understood, little is known about how bacteria manage toxic external ammonia to survive…
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Journal Article
Recent insights into α-carboxysome structure, mechanism, and assembly
ABSTRACT Bacterial microcompartments (BMCs) are pseudo-organelles that sequester metabolic enzymes, intermediates, and/or gases within the bacterial cytosol. One model BMC is the carboxysome (CB). CBs facilitate rubisco-driven fixation of CO2, increasing efficiency and maximizing the…
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Journal Article
Pseudomonas aeruginosa biofilm-deficient mutants undergo parallel evolution during chronic infection
ABSTRACT Pseudomonas aeruginosa readily adapts to infection by acquiring stable and heritable mutations. Previously, we discovered that the first adaptations in a porcine wound model were rugose small-colony variants (RSCVs) caused by mutations in the wsp operon. These mutants overproduce Pel and…
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Journal Article
Adaptive evolution resulted in three subtypes of the Riemerella anatipestifer crpR1 gene
ABSTRACT The global transcription regulator CRP protein controls diverse cellular processes in many bacteria. Our group previously reported that Tn4531 insertion in FIP52_09345 (designated as crpR1), which encodes a special CRP protein without the HTH motif, attenuated the virulence of Riemerella…
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Journal Article
A sterol reductase responsible for the unusual 8(14)-unsaturation in bacterial sterol production and degradation
ABSTRACT Sterols are a class of lipids that play a crucial role in human health through their essential physiological roles and as a point of interaction between commensal and pathogenic bacteria. The biosynthesis and modification of these lipids is a well-characterized process in many eukaryotes…
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Journal Article
The MarR family regulator RmaH underlies the trade-off between acid sensitivity and antibiotic tolerance in Lactococcus lactis
ABSTRACT Microorganisms exhibit remarkable adaptability to diverse environmental stresses through transcriptional reprogramming. Here, we focused on the MarR family regulator RmaH in Lactococcus lactis, which orchestrated a pivotal trade-off: enhancing tolerance to the bacteriocin nisin and the…
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Journal Article
Biological and clinical significance of iron in Pseudomonas aeruginosa biofilms
ABSTRACT Pseudomonas aeruginosa is a ubiquitous gram-negative bacterium that causes diverse opportunistic infections in vulnerable populations. P. aeruginosa is innately resistant to many therapeutic agents, and biofilm-mediated infections demonstrate enhanced recalcitrance to antimicrobials. It…
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Journal Article
Phage-derived proteins and conjugates induce pilus detachment
ABSTRACT Antimicrobial resistance is a growing global health crisis, with ESKAPE pathogens, such as Acinetobacter species, contributing significantly to hospital-acquired infections. These bacteria employ various virulence factors, including extracellular type IV pili (T4P), which serve as…
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Journal Article
A phage-derived reconfigurable effector associated with an actinobacterial contractile nanomachine tailors bacterial responses to competition
ABSTRACT Contractile injection systems (CISs) are derivatives of phage tails and are widely distributed in prokaryotes. CISs load cognate effectors and eject them through contractile actions resembling those of phage tails. Ejected effectors play central roles in CIS functionality by acting on…