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Antimicrobial Agents and Chemotherapy
Scopus
ISSN 1098-6596 · ASM · 410 artikel di indeks
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Artikel Jurnal
Safety, tolerability, and pharmacokinetics of a 2 g subcutaneous dose of ceftriaxone as an alternative to intravenous delivery
ABSTRACT Subcutaneous delivery of antibiotics is a practical alternative to intravenous administration. Ceftriaxone is commonly used for a variety of infections with limited data on the safety and pharmacokinetics of a 2 g subcutaneous dose. This was a prospective, self-controlled cross-over study…
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Artikel Jurnal
In vivo selection of CMY-219 conferring resistance to ceftazidime-avibactam in an OXA-484-producing E. coli ST410
ABSTRACT Resistance to ceftazidime-avibactam (CAZ-AVI) is a growing problem. This study describes the selection of CMY-219, a CMY-42 variant (G156D), conferring resistance to CAZ-AVI in an OXA-484-producing Escherichia coli ST410 after treatment. It raises concern about the risk of selection of CMY…
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Artikel Jurnal
Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates
ABSTRACT Emerging resistance to front-line antimalarials means there is an urgent need to discover new drugs with novel mechanisms of action that remain effective across multiple stages of the parasite life cycle. Previously, we reported a malaria parasite protein kinase, PfCLK3, as a target…
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Artikel Jurnal
Pharmacokinetic-pharmacodynamic target attainment with continuous infusion piperacillin in patients admitted to the ICU with hospital-acquired pneumonia
ABSTRACT Optimizing β-lactam antibiotic exposure in critically ill patients with hospital-acquired pneumonia (HAP) remains a challenge due to significant pharmacokinetic variability, particularly in the setting of renal dysfunction and replacement therapies. Continuous infusion (CI) of…
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Artikel Jurnal
First identification and molecular characterization of CTX-M-15 extended-spectrum β-lactamase and OXA-9 β-lactamase in Haemophilus influenzae in the Iberian Peninsula
ABSTRACT We describe, for the first time, the presence and characterization of CTX-M-15 and OXA-9 in two Haemophilus influenzae strains: PTHi-14525 (CTX-M-15) from Portugal and HUB-HI042681 (OXA-9) from Spain. Multidrug-resistant PTHi-14525 carried blaCTX-M-15 (two copies) and blaTEM-1 in an…
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Artikel Jurnal
Effectiveness and safety of meropenem–vaborbactam versus ceftazidime–avibactam in multidrug-resistant Gram-negative infections: a systematic review and meta-analysis with trial sequential analysis
ABSTRACT Antimicrobial resistance driven by multidrug-resistant (MDR) Gram-negative pathogens poses a major global threat, contributing to substantial morbidity and mortality. Novel β-lactam/β-lactamase inhibitor combinations, particularly meropenem–vaborbactam (M/V) and ceftazidime–avibactam…
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Artikel Jurnal
Improved hydrolysis of piperacillin by OXA-48-like R214G variants, a selective advantage under piperacillin-tazobactam exposure
ABSTRACT OXA-48-like carbapenemases have rapidly disseminated worldwide, becoming the most common carbapenemase in many countries, with more than 60 variants reported. Among them, OXA-244 (OXA-48-R214G) and OXA-484 (OXA-181-R214G) are increasingly reported, despite overall reduced hydrolytic…
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Artikel Jurnal
Pharmacokinetics, safety, and dose optimization of GST-HG171 in renal impairment: insights from physiologically based pharmacokinetic modeling
ABSTRACT GST-HG171 is an orally administered inhibitor of the 3C-like protease that has been approved in China for the treatment of mild to moderate COVID-19. When co-administered with ritonavir, GST-HG171 is eliminated by the kidney. Therefore, this study evaluated the impact of renal impairment…
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Artikel Jurnal
Case Commentary: When susceptibility is not enough in recurrent Burkholderia cenocepacia infection
ABSTRACT In this issue, B. Gaglani, T. M. Andermann, C. Wate, J. Oldan, et al. (Antimicrob Agents Chemother 70:e01542-25, 2026, https://doi.org/10.1128/aac.01542-25) describe a recurrent Burkholderia cenocepacia infection successfully treated with cefiderocol plus sulbactam-durlobactam. Treatment…
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Artikel Jurnal
Population pharmacokinetics of dalbavancin: external validation, model averaging, and implications for precision dosing in prolonged therapy
ABSTRACT Dalbavancin is increasingly used off-label for prolonged therapy in gram-positive infections, but optimal repeat-dosing strategies remain undefined, and published population pharmacokinetic (popPK) models lack external validation in real-world cohorts. A popPK model was developed using…
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Artikel Jurnal
Deciphering the multidrug resistance paradigm in Candida auris
ABSTRACT Candida auris has garnered substantial clinical and public health attention for its widespread antifungal resistance. Most isolates are resistant to fluconazole, and many, to other drug classes, with acquired resistance to all clinically available antifungal drugs reported. Antifungal…
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Artikel Jurnal
Variable chlorhexidine MICs across Klebsiella species from a single facility
ABSTRACT We assessed in vitro chlorhexidine minimal inhibitory concentrations (MICs) across Klebsiella species from a hospital with widespread chlorhexidine use. Isolates underwent MIC testing and whole genome sequencing. Species showed varying resistance, with Klebsiella quasipneumoniae having the…
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Artikel Jurnal
Surveillance for invasive candidiasis in China (CHIF-NET 2018-2021): rising antifungal resistance observed in a nationwide longitudinal study
ABSTRACT Invasive candidiasis (IC) is a severe infection primarily affecting immunocompromised patients and is associated with high mortality and substantial hospital costs. Accurate regional data on epidemiology and antifungal resistance of IC are crucial for effective clinical management. The…
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Artikel Jurnal
Why intrinsic reduced susceptibility in rare fungal pathogens should be differentiated from intrinsic resistance: an ISHAM conceptual framework and narrative review
ABSTRACT Accurate interpretation of antifungal minimum inhibitory concentrations (MICs) requires distinguishing species-level intrinsic phenotypes from isolate-level acquired resistance. Many fungi exhibit intrinsic reduced susceptibility (IRS) reflected by wild-type (WT) MIC distributions that are…
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Artikel Jurnal
Case Commentary: When one target is not enough—PBP3 insertions and target redundancy in Escherichia coli
ABSTRACT This challenging clinical case highlights the impact of PBP3 insertions in Escherichia coli, which reduce susceptibility to key β-lactam agents and complicate treatment, particularly in the setting of NDM production (C. Fabrizio, F. Valzano, S. Giuliano, E. Morelli, et al., Antimicrob…
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Artikel Jurnal
Emergence of antibiotic-resistant pneumococcal serotypes causing invasive pneumococcal disease in children, Spain
ABSTRACT Pneumococcal conjugate vaccines (PCVs) have significantly reduced disease burden caused by Streptococcus pneumoniae, a leading cause of childhood morbidity and mortality globally. The rise of non-vaccine serotypes is a frequent phenomenon after the use of these PCVs. This study is a…