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Zagazig Journal of Pharmaceutical Sciences
ISSN 1110-5089 · Zagazig University, Faculty of Pharmacy · 520 artikel di indeks
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Artikel Jurnal
Imidazoline I1 Receptors and Their Agonists in Neurodegenerative Diseases: Mechanisms and Therapeutic Potential
Imidazoline I1 receptors (I1R) are G protein-coupled receptors expressed in brain regions such as the dorsomedial medulla and reticular formation. Activation of I1R inhibits sympathetic nervous system activity and engages intracellular signaling cascades, including protein kinase C (PKC)…
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Artikel Jurnal
Botanical features, total phenolic and flavonoid contents and antimicrobial activity of Veitchia arecina Becc. leaves cultivated in Egypt
Veitchia arecina Becc. is a member of family Arecaceae. The plant is native to Vanuatu but widely cultivated as an ornamental palm in tropical and subtropical regions, including Egypt. The plant has been previously investigated for its biological activities, particularly antioxidant…
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Artikel Jurnal
Paracetamol Exposure During Pregnancy and Autism Spectrum Disorder: A Meta‑Analysis of Seven European Cohort Studies
Background: Paracetamol (acetaminophen) is widely used during pregnancy as a first-line analgesic and antipyretic. However, concerns regarding its potential neurodevelopmental effects have emerged. This study aimed to evaluate the association between paracetamol exposure during pregnancy and autism…
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Artikel Jurnal
Morphological and Microscopic Characterization of Symphyotrichum squamatum (Spreng.) G.L. Nesom (Asteraceae) growing in Egypt
Symphyotrichum squamatum (Spreng.) G.L. Nesom, a member of the Asteraceae family, is native to South America and naturalized in Egypt. Species within the Asteraceae family, including those in the genus Aster, are characterized by the presence of various metabolites such as terpenes, phenolic…
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Artikel Jurnal
The use of stem cells in diabetes treatment: the journey of development and existing challenges
Background: Diabetes mellitus remains a growing global health concern, with optimal control still difficult to achieve despite insulin therapy, mainly due to increased cellular resistance and progressive β-cell dysfunction. This review aims to highlight the potential of stem cell–based therapies in…
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Artikel Jurnal
Morphological and anatomical characterization of Lobularia arabica (Boiss.) Muschl. (Brassicaceae) using light and scanning electron microscopy
Lobularia arabica (Boiss) Muschl is an herbaceous plant native to Egypt and Palestine. In Egypt it is reported in Mediterranean and Sinai phytogeographical regions. In this study, the root, stem, leaf, flower, fruit and seed macro and micromorphology of L. arabica were examined using light…
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Artikel Jurnal Teks lengkap
The detrimental impact of smoking on osteoporosis: A narrative review
Background: Passive smoking causes an annual death rate, making tobacco use a serious health concern. Chronic smoking is a social risk factor for bone illnesses such as osteo-malacia, diabetic osteopathy, and Paget's disease because it deteriorates muscle function and bone density. The predominant…
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Artikel Jurnal Teks lengkap
A NOVEL PHENOLIC DERIVATIVE FROM THE AERIAL PARTS OF INDIGOFERRA ARRECTA HOCHST. EX A.RICH (PAPILIONOICEAE)
Indigofera arrecta (Papilionoideae) is a widely recognized medicinal plant traditionally used in various cultures for the treatment of ailments such as epilepsy, snakebites, and jaundice. The therapeutic potential of this plant is attributed to its rich phytochemical composition, which includes…
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A Stability indicating TLC-Densitometric Method for the Determination of Remdesivir in presence of Its Degradation Products
The chromatographic analysis of pharmaceutical impurities and degradation products is essential for ensuring drug quality and stability. In this study, a selective, sensitive, and straightforward high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous…
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Artikel Jurnal Teks lengkap
Preclinical Studies of a Multi-Component Herbal Therapy (Rogeria adenophylla J.Gay ex Delile, Bombax costatum Pellegr. & Vuillet, Diospyros mespiliformis Hochst. Ex A.DC. and Entada africana Guill. & Perr.) for the Management of Snake Envenomation
In Northwestern Nigeria, Rogeria adenophylla, Bombax costatum, Diospyros mespiliformis, and Entada africana are traditionally used to treat snakebite envenomation. This study evaluated their antivenom properties against Naja pallida and Echis ocellatus venoms. Toxicity was assessed using Lorke’s…
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Improving the Glimepiride Efficacy in Type 2 Diabetes Treatment: A Review of the Potential Advantages and Disadvantages of Glimepiride as Hypoglycemic Oral Medication.
Type 2diabetes is a major health problem that affects the majority of advanced and developing countries at the same limit ,type 2 diabetes is characterized by insulin resistance which generated after metabolic syndrome induction due to weight gain and low physical activity ,also characterized by…
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Repurposing Finasteride as a quorum sensing inhibitor in Pseudomonas aeruginosa
The emergence of antimicrobial resistance is considered a great problem on a global scale. The decreased supply of antibiotics newly developed adds to this problem needing alternatives such as inhibition of quorum sensing-regulated virulence. Pseudomonas aeruginosa is an opportunistic micror…
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Artikel Jurnal Teks lengkap
Treatment of infections caused by critically resistant Klebsiella pneumoniae strains: Current challenges and future prospectives.
Klebsiella is a Gram-negative bacterium that belongs to family Enterobacteriaceae. Klebsiella pneumoniae is the most pathogenic species of this genus that causes a number of nosocomial and community-acquired infections. Due to the misuse of antibiotics, K. pneumoniae acquires different genetic…
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EUCALYPTUS OIL NANOEMULSION: EVALUATION OF IN VITRO ACTIVITY AGAINST TRYPANOSOMA BRUCEI
Background: Natural products and their secondary metabolites are a good source of pharmacologically active constituents and have been widely developed into modern medicines. The research aims to use an essential oil from eucalyptus and then formulate a nanoemulsion. It would be characterized and…
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Artikel Jurnal Teks lengkap
Carvedilol: New pharmacological approaches
Carvedilol is a non-selective β-blocker with α1-blocking properties which is widely prescribed for treating hypertension, heart failure, and left ventricular dysfunction following myocardial infarction. It has a unique pharmacological profile and acts by several mechanisms of action, making it…
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Artikel Jurnal Teks lengkap
Redefining Bioavailability to Accurately Predict Intracellular Therapeutic Targeting
The COVID-19 pandemic, coupled with ongoing challenges in the development of effective anticancer therapies, has underscored critical limitations in the traditional understanding of bioavailability. Historically, the concept of bioavailability has been narrowly defined, focusing primarily on…
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Association of Plasma Sialic Acid concentrations with Diabetic Nephropathy in Syrian Individuals with Type 2 Diabetes Mellitus
Background: Type 2 Diabetes Mellitus (T2DM) is a significant global health issue, often leading to microvascular complications such as Diabetic Nephropathy, a major cause of chronic kidney disease. The objective of this research was to assess the association between plasma Sialic Acid (SA) levels…
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Date Seed Oil Possesses a Protective Effect Against Paracetamol-induced Hepatotoxicity
Background: Liver is a vital organ performing major metabolic and detoxification reactions, which makes it very liable to damage and injury by a wide range of drugs and xenobiotics. Paracetamol (PCM) is an over-the-counter analgesic that is considered to be safe at therapeutic doses; however…
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Artikel Jurnal Teks lengkap
Design of Potentiometric Sensor Based on Molecularly-imprinted Polymer for Direct Detection of Levofloxacin in Plasma for Point-of-Care Applications
Background: With the goal of "personalizing" the patient's dosage regimen, the concentration of the drug is measured in biological fluids as a part of therapeutic drug monitoring (TDM). A reproducible and disposable molecularly imprinted polymer (MIP)-based potentiometric sensor was constructed as…
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Artikel Jurnal Teks lengkap
In-vitro Antioxidant and Anticancer Studies of Date Palm (Phoenix dactylifera L.) Seed Extract and Its Oil on Seven Cell Lines with Molecular Docking Study Targeting PI3K and EGFR Inhibition
Introduction: Natural products and neutraceuticals are considered important sources of anticancer medicines. The study was conducted to investigate the in-vitro antioxidant and anticancer activities of date palm (Phoenix dactylifera L.) seed extract (DPSE) and its oil (Oi-Y) against seven cancer…