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European Journal of Histochemistry
Scopus
ISSN 1121-760X · PAGEPress Publications · 1.671 artikel di indeks
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Artikel Jurnal
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway
G protein-coupled estrogen receptor 1 (GPER1) has extensively verified as a tumor regulator in various types of cancers. However, its role in esophageal cancer (EC) remains largely unclear. In this study, the expression and prognostic prediction value of GPER1 in EC was analyzed by using TCGA…
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Low ozone concentrations promote in vitro preservation of explanted articular cartilage: an ultrastructural study
Ozone (O3) is an oxidizing natural gas widely applied as adjunctive therapeutic treatment for a variety of pathological conditions. Currently, O3-based therapies rely on the low-dose concept i.e., the administration of low O3 concentrations able to induce a mild oxidative stress stimulating…
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Immunohistochemical detection of putative pathogenetic factors in adhesions of infants: a pilot study
Newborns’ intestinal adhesions have been reported in 4.7% infants who underwent a laparotomy, but adhesions can also appear idiopathically. Etiology and pathogenesis of adhesions is still to be determined, but evidence shows relation to inflammation, formation of fibrin bands, hypoxia and tissue…
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Histopathological and immunofluorescent characterization of post-sepsis immune dysregulation in a clinically relevant mouse model
Sepsis remains a major cause of morbidity and mortality worldwide, yet its prolonged pathophysiological consequences are poorly understood. Here, we employed a murine cecal ligation and puncture (CLP) model to investigate the prolonged impact of sepsis on survival, systemic inflammation, and organ…
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Cryptotanshinone alleviates DSS-induced colitis in mouse by regulating the balance of Treg/Th17 cells and M1 macrophage activation
Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn's disease has become a global disease in the 21st century, with increasing incidence rates in almost every industrialized country. Previous studies have suggested that the traditional Chinese medicine herb…
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Back to the future: improving storage of Golgi-stained mouse brain
Morphological analysis of neuronal processes and their networks is a key aspect of neuroscience, with relevance from basic research to clinical practice due to the central role of neuronal development and plasticity in many neurological disorders. More than a century after its introduction, Golgi…
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SRSF3 promotes the generation of XBP1s to stabilize autophagy and enhance hypoxia adaptation in glioma
Hypoxia is a key driver of glioblastoma (GBM) progression. Serine/arginine-rich splicing factor 3 (SRSF3) is associated with the malignant progression of GBM, but its role in the hypoxic microenvironment of GBM remains unclear. This study aimed to explore the regulatory role and molecular…
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SPRR2B knockdown inhibits the proliferation and inflammatory response in M5-treated human HaCaT keratinocytes
Psoriasis is a chronic inflammatory skin disease characterized by keratinocyte hyperproliferation and excessive immune activation, for which curative therapies remain limited. This study aimed to investigate the role of small proline-rich protein 2B (SPRR2B) in psoriasis pathogenesis. In this…
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Downregulation of GMPS inhibited the proliferation of hepatocellular cancer cells via the regulation of STAT3/c-Myc pathway
Hepatocellular cancer (HCC) is the sixth most common type of cancer worldwide. Guanosine monophosphate synthase (GMPS) participates in the regulation of chromatin and genes in various organisms, and is highly expressed in a number of human malignant tumors. However, the role of GMPS in HCC has not…
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Histochemical characterization of TDAG51 in endothelial remodeling and angiogenesis following myocardial infarction via PI3K-AKT signaling
Myocardial infarction (MI) triggers complex cardiac remodeling, including endothelial dysfunction, fibrosis, and angiogenesis. Characterizing the spatial distribution and cellular localization of regulatory molecules is critical for understanding cardiac repair mechanisms. This study investigated…
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Artikel Jurnal
01 | OVERCOMING HORMONAL BARRIERS TO CARDIAC REGENERATION
Cardiomyocyte loss after acute or chronic myocardial injury is a major cause of heart failure. Adult mammalian cardiomyocytes retain a very limited proliferative capacity, insufficient for effective regeneration. A key goal in cardiac regenerative medicine is therefore to stimulate endogenous…
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02 | MODELING NON-CELL AUTONOMOUS MECHANISMS IN THE ALS PERIPHERAL NERVOUS SYSTEM
Amyotrophic lateral sclerosis (ALS) has long been viewed as a motor neuron disease, with research focusing on the intrinsic vulnerability of these neurons. While this approach has advanced understanding of disease mechanisms, it has also led to the underappreciation of non-cell-autonomous…
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03 | DISTINCTIVE HOMEOSTATIC BALANCE IN CHILDHOOD OBESITY AND ITS RELATIONSHIP WITH BONE HEALTH
Childhood obesity is characterized by persistent meta-inflammation that disrupts both metabolic and skeletal homeostasis, potentially leading to long-term health consequences. The interplay between chronic inflammation, impaired insulin signaling, and gut microbiota dysbiosis offers an integrated…
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04 | MODULATION OF NEUROINFLAMMATION IN IL-1BETA-INDUCED HUMAN ASTROCYTES: EFFECTS OF GREEN LEAVES AND RHIZOMES EXTRACT FROM POSIDONIA OCEANICA (L.) DELILE
Marine-derived bioactive compounds have attracted increasing attention due to their antioxidant, anti-inflammatory and neuroprotective properties. Extracts from leaves (GLE) and rhizomes (RE) of Posidonia oceanica (L.) Delile are rich in polyphenols and have demonstrated anti-inflammatory effects…
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05 | MITOCHONDRIA DANCE WITH LIGHT: HOW WAVELENGTH CHOREOGRAPHS RESPIRASOMA, NITRIC OXIDE AND OXIDATIVE PHOSPHORYLATION
The conversion of light energy into chemical energy in chloroplasts and the substrate-dependent oxidation in mitochondria represent the two pillars of eukaryotic bioenergetics, united by an extraordinary architectural homology that reveals their common prokaryotic origin. Although differing in…
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06 | OBESITY-INDUCED TESTICULAR DYSFUNCTION: PROTECTIVE ROLES OF THYROID HORMONES IN HIGH-FAT DIET-FED RATS
Obesity, through chronic lipotoxicity and oxidative stress, adversely affects multiple aspects of testicular function and represents a significant risk factor for male infertility. 3,5-diiodo-L-thyronine (T2), an endogenous thyroid hormone metabolite with recognized metabolic and mitochondrial…
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07 | FROM GUT MICROBIOTA TO GONADS: BUTYRATE MITIGATES PFAS–PESTICIDE MIXTURE TOXICITY IN ZEBRAFISH SPERMATOGENESIS
Endocrine-disrupting chemicals (EDCs) are ubiquitous contaminants that occur as environmental mixtures and reported to impair reproductive function. Glyphosate (GLY) and perfluorooctanoic acid (PFOA), commonly detected in water and food, contribute to chronic low-dose exposure in humans and…
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08 | HUMAN ADIPOSE STEM CELLS: IMPACT OF DONORS’ AGE ON CELL PROPERTIES AND BEHAVIOUR
Aging is defined as the accumulation of alterations in cells and tissues that increase the risk of disease. Therefore, the increase in life expectancy in our society is more likely to be accompanied by increased age-related disorders, which are commonly linked to impaired angiogenesis and tissue…
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11 | FROM SIGNALING TO STRUCTURE: TYPE 1 DIABETES DISRUPTS ACTIN NETWORKS IN TESTIS AND SPERMATOZOA
Type 1 diabetes (T1D) is a systemic metabolic disorder that affects not only glucose homeostasis but also the physiology of the male reproductive system. In particular, alterations in cytoskeletal organization have emerged as a key determinant of impaired spermatogenesis. This study investigated…
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10 | ASSESSING RECOVERY FROM HYDROCARBON SPILL EXPOSURE IN MEDITERRANEAN MUSSEL MYTILUS GALLOPROVINCIALIS: A MULTI-BIOMARKER APPROACH
Oil spills are among the most dangerous and unpredictable marine pollution events, threatening the health of entire ecosystems. In this context, assessing the ability of marine organisms to return to pre-stress conditions is of particular interest and importance. This study investigated the…
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