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The Journal of Headache and Pain
Scopus
ISSN 1129-2369 · BMC · 1,687 articles in the index
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Journal Article
Evolution of use and overuse of triptans in Austria – What has changed in the last 15 years?
Abstract Background Triptans are highly effective acute treatments for migraine attacks, yet population-level data suggest persistent underuse. Updated real-world data on triptan use and overuse in Austria are lacking. Methods This nationwide, retrospective claims-based study analysed triptan use…
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Journal Article
Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial
Abstract Background Cyclic guanosine monophosphate (cGMP)-mediated mechanisms plays a role in migraine pathophysiology. Sildenafil, a phosphodiesterase type 5 inhibitor, increases intracellular cGMP and can reliably induce migraine attacks in women. However, its migraine-inducing potential in men…
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Journal Article
Spreading depolarization activates the cGAS–STING pathway and drives cranial nociception: therapeutic potential of STING modulation
Abstract Background Spreading depolarization (SD) is a transient wave of near-complete neuronal and glial depolarization in the cortex which underlies migraine aura. Beyond its electrophysiological effects, SD has been shown to trigger a cascade of sterile neuroinflammatory responses which may…
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Journal Article
Sleep macro- and microstructure in migraine and cluster headache: a systematic review of objective assessments
Abstract Background Patients with primary headache disorders including migraine and cluster headache often report poor sleep quality. While subjective reports of disturbed sleep are well established, the objective alterations in sleep architecture which occur in primary headache have not been…
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Journal Article
Medication overuse headache from a tertiary headache center in Egypt: real-world insights
Abstract Background Medication-overuse headache (MOH) is a secondary headache disorder often underrecognized in low- and middle-income countries. This study provides the first real-world data on MOH prevalence and clinical characteristics from a tertiary care center in Egypt. Methods A…
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Journal Article
Decoding the long-term safety of anti-CGRP (receptor) mAbs: a meta-analysis and systematic review
Abstract Objective To evaluate the long-term safety (≥12 months) of monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) or its receptor in migraine prevention by synthesising evidence from clinical trials and real-world studies. We focus on drug discontinuation due to…
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Journal Article
Elucidating the susceptibility genes between insomnia and migraine by integrating genetic data and transcriptomes
Abstract Background Insomnia is a sleep disorder commonly occurring in the general population. Migraine is a severe neurological disease with a high morbidity rate. Insomnia can increase the risk of developing migraines. However, the full biological mechanisms underlying this condition remain…
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Journal Article
Real-world assessment of current migraine prophylaxis in Egypt: a multicenter national study
Abstract Background & objectives Prophylactic treatment plays a crucial role in reducing the frequency, severity, and duration of migraine attacks. This study, the first to address this issue in Egypt, aimed to study the patterns of prophylactic treatment utilization among individuals with migraine…
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Journal Article
Sex differences in cluster headache: insights from the Chinese Cluster Headache Register Individual Study (CHRIS)
Abstract Background Sex differences in the clinical characteristics of cluster headache (CH) remain controversial in both Eastern and Western studies, and such differences have not been thoroughly investigated among Chinese patients. Methods This large-scale, multicenter cohort study included 1,206…
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Journal Article
Hypothalamic and sex-related hormones in migraine
Abstract The hypothalamus and sex hormones are closely linked to primary headache disorders. Migraine is the most prevalent disabling neurological disorder, affecting up to 15% of the global population, with enormous socioeconomic and personal impacts. It ranks second among years lived with…
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Journal Article
Prevalence, medication use, and health care utilization in pediatric primary headache: a school-based cross-sectional study
Abstract Background Primary headache disorders are the most common neurological conditions affecting children and adolescents and among the leading causes of disability worldwide. However, population-level data on prevalence, medication use, and health care utilization remain limited. This study…
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Journal Article
Electrophysiological evidence about sexual dimorphism in the clonidine-induced inhibition of trigeminal wide dynamic range cell activity
Abstract Background The trigeminal system plays a key role in headaches pathophysiology. In this regard, nociceptive experiments in male rodents have shown that at the trigeminal level, clonidine induces antinociception through α2A- but not α2B/2C-adrenoceptors. Interestingly, although behavioural…
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Journal Article
Triggers, prodrome, aura, and headache interactions in migraine with typical aura: a prospective deep-phenotyping study
Abstract Aims This study aimed to prospectively and comprehensively phenotype migraine with typical aura (MwA) attacks, with a particular focus on the interaction between trigger factors and clinical features of the prodrome, aura, and headache phases. A secondary aim was to examine how…
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Journal Article
Association of migraine with subsequent risk of depression or anxiety by small-area deprivation: national cohort study with sibling analysis
Abstract Background Growing evidence indicates that migraine could increase the risk of depression or anxiety in affected persons. Residential deprivation, with its links to stressful environments and access to quality services, could exacerbate the risk of developing depression or anxiety among…
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Journal Article
Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study
Abstract Background and objectives Oxytocin has been implicated in migraine pathophysiology through its roles in pain modulation and vascular regulation. Its receptors are present in migraine-related brain regions and cerebral vessels and interact with key migraine mediators such as calcitonin…
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Journal Article
Effectiveness and safety of anti-CGRP monoclonal antibodies in hemiplegic migraine: an individual patient quantitative analysis
Abstract Background Hemiplegic migraine (HM) is a rare and disabling subtype of migraine with aura characterized by reversible motor weakness. Preventive treatment remains challenging, as patients with HM are systematically excluded from RCTs. Monoclonal antibodies targeting the calcitonin…
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Journal Article
Altered serum short-chain fatty acid profiles in episodic and chronic migraine and their modulation by preventive treatment
Abstract Background Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are gut-microbiota-derived metabolites implicated in gut–brain communication. This study aimed to characterize serum SCFA profiles in individuals with episodic migraine (EM) or chronic migraine (CM)…
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Journal Article
Noradrenergic system involvement as a major driver of tension-type headache: a systematic review of the current evidence
Abstract Background Tension-type headache (TTH) is the most prevalent primary headache disorder, affecting individuals of all ages and imposing a substantial global burden. While traditionally considered a peripheral skeletomuscular condition, current evidence suggests a prominent role for central…
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Journal Article
Downregulation of neuronal DRD2 drives microglia synaptic pruning and results in cognitive deficits by promoting CCL2 release in a rat model of chronic migraine
Abstract Chronic migraine (CM) is a disabling neurological condition increasingly recognized for its link to cognitive deficits and a potential higher dementia risk. Although microglia-mediated synaptic pruning has been associated with cognitive decline, its role in CM is not fully understood. The…
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