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Cancer Informatics
Scopus
ISSN 1176-9351 · SAGE Publishing · 1.151 artikel di indeks
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Artikel Jurnal
Prospective Breast Cancer Biomarkers Identified Using miR-526b-Driven Metabolic Alterations
Objectives: Breast cancer is a heterogeneous disease driven by dysregulated cellular processes, including altered metabolic pathways. The oncogenic microRNA miR-526b influences several cancer hallmark phenotypes and holds promise as a plasma biomarker. Given miR-526b’s role in metabolic regulation…
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Artikel Jurnal
MGDB: A Novel Bioinformatics Quality Control Tool for Clinical Next-Generation Sequencing
Background and Objectives: Next-generation sequencing (NGS) is transforming clinical diagnostics by enabling the detection of genetic variation with unprecedented precision. However, successful implementation of NGS workflows necessitates stringent quality control. This study introduces Molecular…
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Artikel Jurnal
Genetically Predicted Gut Microbiota in Correlation with the Risk of Head and Neck Cancer
Background Existing evidence supports observational associations between the gut microbiome composition and susceptibility to extraintestinal cancers; however, the causal relationship between gut microbiome composition and the risk of developing head and neck cancer (HNC) remains uncertain…
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LEPR Contributes to Lung Squamous Cell Carcinoma: Insights From Mendelian Randomization and Experimental Studies
Background The involvement of certain adipokines link to carcinogenesis, development, and prognosis. However, the roles of adipokines in lung cancer and its histological subtypes remains indistinct. Therefore, the aims of this study are to explore the causal relationship between adipokines and lung…
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Artikel Jurnal
The MAPK Pathway Coordinates an Immunosuppressive Microenvironment in Colorectal Cancer: A Single-Cell Guided Prognostic Model
Background: The immunosuppressive tumor microenvironment in colorectal cancer is a key factor in its progression and treatment resistance, yet the coordinated mechanisms of its cellular composition and signaling networks are not fully understood. This study aims to explore the regulatory foundation…
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Artikel Jurnal
Multi-Scale Cross-Attention Multiple Instance Learning Network for Automated Classification of Colorectal Polyps
Objectives The Gastrointestinal (GI) Pathology subspecialty at our medical center is the highest-volume service in our Anatomic Pathology division, with colon polyps constituting 40% of specimens. 2021 revisions to colorectal cancer screening guidelines lowered the screening age to 45, which may…
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Artikel Jurnal
Integrated Ferroptosis and Immune Features Are Associated With Overall Survival in Bladder Urothelial Carcinoma: A TCGA-Based Analysis
Objectives: To investigate the prognostic value of ferroptosis-related and immune-related transcriptional features in bladder urothelial carcinoma (BUC) and to evaluate whether their integration provides incremental prognostic information beyond conventional clinical factors. Methods…
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Artikel Jurnal
Decitabine Induces Subtype-Specific Epigenomic Remodeling and Perturbs Age-Associated Regulatory CpGs in Breast Cancer
Objectives: Breast cancer (BC) subtypes such as HR+, HER2+, and triple-negative (TNBC) show distinct molecular features, treatment responses, and outcomes. DNA methylation is a key, targetable epigenetic regulator in BC. This study examined whether the DNA methyltransferase inhibitor decitabine…
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Artikel Jurnal
iCRCexp: An Integrative Database for Colorectal Cancer-Associated Gene Expression Profiles
Background: Colorectal cancer (CRC) is a leading cause of tumor-related mortality. Recent studies have shown that the transcriptome plays an important role in the development and occurrence of CRC. However, a comprehensive repository of CRC transcriptome sequencing data is unavailable. In the…
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Artikel Jurnal
Clinical Significance of SDC2 in Gastric Cancer: Insights From a Multi-Center Cohort Study
Objectives: Gastric Cancer (GC) poses a significant global health challenge, necessitating effective biomarkers for early detection and prognosis. This study investigates the relationship between SDC2 expression and GC patient outcomes. Methods: We analyzed SDC2 expression in GC and its association…
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Artikel Jurnal
Translating Data Into Clinical Tools: An Integrative Strategy for Precision Biomarker Identification in Soft Tissue Sarcoma Diagnosis and Prognosis
Objectives Soft tissue sarcomas (STSs) are rare, heterogeneous cancers with over 70 subtypes, often diagnosed late due to diagnostic complexity, leading to poor outcomes. We aimed to identify and validate novel transcriptomic biomarkers for the diagnosis and prognosis of STS using an integrative…
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Artikel Jurnal
Transcriptome-Wide Cox Regression Identifies Candidate Survival-Associated Genes in Newly Diagnosed Acute Myeloid Leukemia
Objectives Acute myeloid leukemia (AML) exhibits substantial biological heterogeneity that is not fully captured by current prognostic systems. We aimed to identify transcriptome-wide gene expression markers associated with overall survival in newly diagnosed AML patients. Methods Gene expression…
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Artikel Jurnal
Integrative Analysis of Steroid Metabolism–Based Molecular Subtypes Reveals Prognostic Subtypes and Therapeutic Implications in Gastric Cancer
Objective This study aimed to identify steroid metabolism–related molecular subtypes, investigate the gene expression patterns of these subtypes, and construct a prognostic risk model as well as predict therapeutic response in gastric cancer. Methods We analyzed 410 TCGA-STAD and 483 GSE84437…
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Artikel Jurnal
Contextualized Malignantization: Morphometric Signatures of Breast Tissue Transformation and a Clinically Translatable Diagnostic Algorithm
Background The transformation from benign to malignant breast tissue represents a complex biological continuum rather than a discrete pathological switch. Current diagnostic paradigms rely heavily on binary classification systems that may inadequately capture the nuanced morphometric signatures…
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Artikel Jurnal
Single-Cell Transcriptome Analysis Reveals IRF1-Driven Epithelial States and Glycosaminoglycan–Glycolysis Coupling in Cisplatin-Resistant HGSOC
Objectives Cisplatin resistance is the principal cause of relapse in high-grade serous ovarian cancer (HGSOC), but bulk-expression signatures cannot localize resistant malignant states or the tumor–microenvironment (TME) interactions that sustain them. This study aimed to define cisplatin-resistant…
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Artikel Jurnal
Integrated Bioinformatic and Molecular Characterization of the miR-4303/miR-4291–MAPK1 Axis in Oral Squamous Cell Carcinoma
Objective Oral squamous cell carcinoma (OSCC) is characterized by high recurrence rates and an unclear underlying molecular basis, highlighting the need for improved early diagnostic strategies to enhance treatment outcomes and reduce healthcare burden. Given the regulatory role of microRNAs…
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Artikel Jurnal
GATES: A Lightweight Tool Automating Pathogenic Variant Discovery From Raw Whole-Exome Sequencing Data
Background Whole-exome sequencing is a widely used technology to identify pathogenic variants in cancer. Although sequencing itself has become increasingly accessible, downstream analysis remains computationally complex, presenting a challenge for many researchers. Existing pipelines lack…
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Artikel Jurnal
-Derived p-Cresyl Metabolites Induce Inflammation and Apoptosis in Biliary Epithelial Cells
Objective Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease, and the effects of p-cresyl sulfate (PCS) and p-cresyl glucuronide (PCG) in PBC remain unclear. This study aimed to evaluate the pro-apoptotic and pro-inflammatory effects of PCS and PCG. Methods Human…
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Artikel Jurnal
Development and Validation of a Six-Gene Signature of Myeloid Antigen Presentation Dysfunction Based on Single-Cell and Multi-Cohort Transcriptomics for Predicting Prognosis and Recurrence of Hepatocellular Carcinoma
Background: Myeloid antigen-presentation dysfunction is a central but incompletely translated immune state in hepatocellular carcinoma (HCC). This study aimed to develop a compact prognostic and recurrence model directly anchored in single-cell-defined myeloid antigen-presentation loss. Methods: In…
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Artikel Jurnal
A Glutathione Metabolism-Related Transcriptomic Signature for Prognostic Assessment and Biological Characterization of Lung Adenocarcinoma
Background Glutathione metabolism plays an important role in redox homeostasis, oxidative stress responses, and metabolic adaptation in cancer. However, its prognostic significance in lung adenocarcinoma (LUAD) remains incompletely understood. This study aimed to develop a glutathione…
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