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Biomarker Insights
Scopus
ISSN 1177-2719 · SAGE Publishing · 688 artikel di indeks
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Artikel Jurnal
Abnormal Serum Albumin, Alanine Aminotransferase, and Blood Urea Nitrogen are Associated with Higher Risks for Mechanical Ventilation and In-Hospital Mortality in COVID-19 Positive US Veterans
Background: Since the first reported case of Coronavirus Disease 2019 (COVID-19), clinicians and scientists have been challenged to contrive ideal prevention, detection, and treatment strategies. As the death toll surpasses 1 million in the United States, identifying disease risk factors…
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Artikel Jurnal
Unlocking Colorectal Cancer Diagnostics With Circulating Progastrin (hPG80): A Scoping Review
Colorectal cancer (CRC) represents a significant global health concern, ranking as the third most diagnosed cancer and the second leading cause of cancer deaths in the UK. Although population-based bowel cancer screening programs (BCSP) facilitate early diagnosis, uptake remains variable…
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Artikel Jurnal
Visual Confirmation of Residual Erythrocytes and Platelets in Human Plasma
Background Human plasma stored in biobanks serves as a starting material for many biomarker studies. Despite being termed “platelet-free plasma”, plasma still contains erythrocytes and platelets at concentrations below the limit of detection of routine haematology analysers, approximately 10 6 mL…
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Artikel Jurnal
Bacterial Fluorescence-Based Biosensor for Detecting Propionate in Culture Media for Diagnostic Applications
Background Engineering bacteria for disease diagnosis and treatment is an emerging area of medical research that involves assessing short-lived molecules in complex, dynamic environments. Detecting metabolites in situ offers significant opportunities for identifying responsive cellular populations…
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Artikel Jurnal
Salivary Biomarkers for Diagnosis and Monitoring of Thyroid Diseases: A Systematic Review of Current Evidence
Background: Thyroid hormones have a crucial impact on all physiological systems. Diagnosis of thyroid diseases using salivary biomarkers is an emerging discipline and requires consolidation of existing information. Aims: This systematic review is aimed at identifying and analyzing salivary…
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Artikel Jurnal
Urinary Calprotectin Predicts Severe Acute Kidney Injury After Non-cardiac Surgery in Surgical Intensive Care Unit: A Prospective Cohort Study
Background Postoperative risk stratification for severe acute kidney injury (AKI) can facilitate timely intervention and improve prognosis. Objectives This study aimed to evaluate the added predictive ability of urinary calprotectin for postoperative risk stratification of severe AKI in non-cardiac…
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Artikel Jurnal
Insight to Neglected Biomarkers in COVID-19: A Comprehensive Narrative Review”
In the context of COVID-19, a range of neglected biomarkers provide critical insights into the mechanisms of the disease and potential therapeutic targets. This review aims to address this gap by systematically analyzing the diagnostic and prognostic potential of these neglected biomarkers, with…
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Artikel Jurnal
Short-Term Molecular Assessment of Peripheral Blood Transcriptomics and Urinary Metabolomics After Switching From Cigarettes to Heated Tobacco Products Using Machine Learning and Bayesian Network Modeling
Background Omics approaches can provide mechanistic insights into biological changes after changes in smoking behavior. However, data on short-term molecular changes after changes in tobacco product use are limited. Objectives To compare 5-day molecular changes in peripheral blood gene expression…
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Artikel Jurnal
Association Between Khat () Consumption and Hepatocellular Enzyme Elevation: A Hospital-Based Case-Control Study
Background Khat (Catha edulis) is a widely consumed stimulant in East Africa, but its role in hepatocellular alterations remains debated. Objectives This study evaluated the association between khat consumption patterns and subclinical liver injury in Somaliland. Design A hospital-based…
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Artikel Jurnal
Neurofilaments in Tears as Early Biomarkers of Corneal Neurodegeneration in Diabetes Without Retinopathy
Background: Neurodegeneration in the cornea, particularly in diabetic patients, is an emerging area of research that highlights the potential of tear fluid as a source of biomarkers. Neurofilaments light chain (Nf-L), which are structural proteins found in neurons, have been identified as promising…
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Artikel Jurnal
Multi-Target Cardioprotective Potential of Phytochemicals: An Integrated Network Pharmacology and Molecular Docking Approach
Background Myocardial infarction (MI), especially its adrenaline-induced myocardial injury, remains a leading cause of global mortality, often resulting in irreversible cardiac damage and heart failure due to stress cardiomyopathy. Objectives Ajuga bracteosa Wall. ex Benth. (Lamiaceae). It is a…
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Artikel Jurnal
Molecular Protein Interactions and Predictive Pathways as Biomarkers for Enhancing Volleyball Performance: A Narrative Review
Background Understanding molecular protein interactions offers promising long-term health benefits for volleyball players by serving as biomarkers that enable predictions of metabolic status, inflammation, injury risk, and recovery potential. Objective This review aims to clarify the molecular…
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Artikel Jurnal
Association of IL-1β, IL-6, IL-8, IL-12, TNF-α, and IFN-α With Severe Pediatric COVID-19 and Multisystem Inflammatory Syndrome
Background The cytokine profile may provide clinically relevant information for assessing the inflammatory response in infectious diseases, including SARS-CoV-2. However, the threshold concentrations of cytokines associated with severe pediatric COVID-19 and cytokine patterns related to multisystem…
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Artikel Jurnal
Assessment of Brain-Specific and Neuroendocrine Biomarkers for Intracerebral Hemorrhage Diagnosis: A Prospective Cohort Study
Background and Purpose The timing of diagnosis is a critical factor that significantly impacts medical treatment and patient outcomes in individuals with intracerebral hemorrhage (ICH). The study primarily aimed to evaluate the diagnostic potential of four brain-specific biomarkers, glial…
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Artikel Jurnal
Molecular Insights into the Regulatory Mechanisms Mediated by Hypoxia-Conditioned Skeletal Muscle Exosomal miRNAs
Background: Hypoxia alters skeletal muscle metabolism and function through complex regulatory mechanisms, including exosome-mediated microRNA (miRNA) signaling. Objectives: This study profiled exosomal miRNAs from hypoxic human skeletal muscle cells (HSMCs) to explore their roles in hypoxic…
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Artikel Jurnal
Galectin-3 Is Independently Associated With Short-Term Mortality and Identifies Low-Risk Patients With Acute Dyspnea in the Emergency Department: A Retrospective Cohort Study
Background: Dyspnea is a common and diagnostically challenging symptom in the emergency department (ED), particularly among older adults with multimorbidity. Traditional risk stratification tools often perform poorly in this population. Galectin-3 (Gal-3), a biomarker of inflammation and fibrosis…
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Artikel Jurnal
Translating Liquid Biopsy into Practice- The Promise and Challenges of Circulating Tumor Cells in Ovarian and Lung Cancer Management
The increasing mortality from ovarian and lung cancers worldwide is largely due to late diagnosis and therapeutic resistance. Conventional biomarkers such as CA125 and CYFRA 21-1 lack the sensitivity or the specificity for monitoring real time disease progression or therapeutic response. This has…
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Artikel Jurnal
Circulating EMID2 as a Prognostic Biomarker of Poor Outcomes in Patients with Metastatic Colorectal Cancer
Background: EMID1 and EMID2 (also known as type XXVI collagen) are extracellular matrix (ECM) proteins that belong to the EDEN gene superfamily. Both proteins feature EMI domains, implicating them in protein-protein interactions and ECM remodeling. Despite structural similarities EMID1 and EMID2…
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Artikel Jurnal
Extracellular Matrix-Related Prognostic Signature for Head and Neck Squamous Cell Carcinoma via Multi-Algorithm Survival Modeling
Background Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis, and the extracellular matrix (ECM) plays a key role in tumor progression, emerging as a potential biomarker for prognosis and therapy. Objectives To develop and validate an ECM-related prognostic signature (ECMS) and…
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Artikel Jurnal
A Cohort Study on Dual Predictive Markers of Immune Combination Therapy for Advanced Non-Small Cell Lung Cancer
Background: Immune checkpoint inhibitors (ICIs) hold a great promise in treatment of non-small cell lung cancer (NSCLC), while only a portion of patients benefited from the treatment, and others could not achieve optimal therapeutic effects from initial immunotherapy, even for those patients with…