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Journal of Experimental Neuroscience
ISSN 1179-0695 · SAGE Publishing · 236 artikel di indeks
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Artikel Jurnal
Discovering Conserved Properties of Brain Organization Through Multimodal Integration and Interspecies Comparison
The primate cerebral cortex is broadly organized along hierarchical processing streams underpinned by corresponding variation in the brain’s microstructure and interareal connectivity patterns. Fulcher et al. recently demonstrated that a similar organization exists in the mouse cortex by combining…
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Mosaic Gene Recombination in Alzheimer’s Disease—What’s Next?
A first example of somatic gene recombination (SGR) within the human brain was recently reported, involving the well-known Alzheimer’s disease (AD)-related gene amyloid precursor protein ( APP ). SGR was characterized by the creation of APP genomic complementary DNA (gencDNA) sequences that were…
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Suppression of MAP4K4 Signaling Ameliorates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis-Molecular Studies Toward New Therapeutics
Amyotrophic lateral sclerosis (ALS), the most common motor neuron (MN) disease of adults, is characterized by the degeneration of upper MNs in the motor cortex and lower MNs in the brain stem and spinal cord. Our recent work suggests that a MAP kinase family member, MAP4K4 (mitogen-activated…
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MicroRNAs in Brain Cancer: Look at the Forest, Not at the Tree
Much is known about microRNA biology and their involvement in essentially any biological processes in eukaryotic cells, including cancer. Now, to take advantage of them in clinics, a change in perspective is needed and a reappraisal of their features is warranted to re-ignite interest and…
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Investigation of Theta Rhythm Effect in Detection of Finger Movement
Movements cause changes in cortical rhythms emanating from the sensorimotor area. It is known that alpha and beta brainwaves take an important role of motor activity and motor imagery. Besides, theta rhythm is considered to carry substantial information about movement initiation and execution. In…
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A Mechanism for the Development of Chronic Traumatic Encephalopathy From Persistent Traumatic Brain Injury
A mechanism that describes the progression of traumatic brain injury (TBI) to end-stage chronic traumatic encephalopathy (CTE) is offered in this article. This mechanism is based upon the observed increase in the concentration of both tau protein and of human leukocyte antigen (HLA) class I…
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ZPR1-Dependent Neurodegeneration Is Mediated by the JNK Signaling Pathway
The zinc finger protein ZPR1 deficiency causes neurodegeneration and results in a mild spinal muscular atrophy (SMA)-like disease in mice with reduced Zpr1 gene dosage. Mutation of the survival motor neuron 1 ( SMN1 ) gene causes SMA. Spinal muscular atrophy is characterized by the degeneration of…
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Synchronous Interactions Foster Empathy
Despite growing interest in the neuroscience of empathy, very little is known about the developmental processes that foster the neural maturation of an empathic response. Here, we suggest that the synchronous interaction shapes and fosters the ability to empathize with others. We argue that this…
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Neurodegeneration, Heterochromatin, and Double-Stranded RNA
Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between…
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Unifying Pathophysiological Explanations for Sports-Related Concussion and Concussion Protocol Management: Literature Review
Objective: There is a plethora of theories about the pathophysiology behind a sport-related concussion. In this review of the literature, the authors evaluated studies on the pathophysiology of sport-related concussion and professional athlete return-to-play guidelines. The goal of this article is…
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Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model
Several studies have noted a correlation between retinal degeneration and traumatic encephalopathy (TE) making the retina a leading candidate for detection and assessment. Scattering-angle-resolved optical coherence tomography (SAR-OCT) is a candidate imaging modality to detect sub-resolution…
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Blast-Related Traumatic Brain Injury: Current Concepts and Research Considerations
Traumatic brain injury (TBI) is a well-known consequence of participation in activities such as military combat or collision sports. But the wide variability in eliciting circumstances and injury severities makes the study of TBI as a uniform disease state impossible. Military Service members are…
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Diffusion Tensor Imaging of the Evolving Response to Mild Traumatic Brain Injury in Rats
Mild traumatic brain injury (mTBI), also known as concussion, is a serious public health challenge. Although most patients recover, a substantial minority suffers chronic disability. The mechanisms underlying mTBI-related detrimental effects remain poorly understood. Although animal models…
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Quantification of surviving neurons after contusion, dislocation, and distraction spinal cord injuries using automated methods
This study proposes and validates an automated method for counting neurons in spinal cord injury (SCI) and then uses it to examine and compare the surviving cells in common types of SCI mechanisms. Moderate contusion, dislocation, and distraction SCIs were surgically induced in Sprague Dawley male…
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A Further Analysis and Commentary on: Profiling Changes in Cortical Astroglial Cells Following Chronic Stress
The neuroplasticity hypothesis of depression proposes that major depressive disorders are related to decreased hippocampal and cortical neural plasticity, which is reversed by antidepressant treatment. Astroglial cells have emerged as key mediators of neural plasticity and are involved in the cause…
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What Is Excitation/Inhibition and How Is It Regulated? A Case of the Elephant and the Wisemen
The balance between excitation and inhibition in neuronal circuits has drawn more and more attention in recent years, due to its proposed multifaceted functions in the normal neural circuit as well as its potential roles in the etiology of many neurological disorders. Here, we discuss the…
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Rev-erbs and Glia—Implications for Neurodegenerative Diseases
Recently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist diminished the severity of lipopolysaccharide…
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Obesity Impairs Mobility and Adult Hippocampal Neurogenesis
Currently, it is controversially discussed whether a relationship between obesity and cognition exists. We here analyzed a mouse model of obesity (leptin-deficient mice) to study the effects of obesity on the morphology of the hippocampus (a brain structure involved in mechanisms related to…
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Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration
Multiple approaches to therapy have been proposed for the rare inherited neurodegenerative disease associated with mutations in the PANK2 gene, called pantothenate-kinase-associated neurodegeneration (PKAN). Penetration of the blood-brain barrier for treatment of a central nervous system (CNS)…
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Artikel Jurnal
Interneuron Diversity: Toward a Better Understanding of Interneuron Development In the Olfactory System
The Drosophila olfactory system is an attractive model for exploring the wiring logic of complex neural circuits. Remarkably, olfactory local interneurons exhibit high diversity and variability in their morphologies and intrinsic properties. Although olfactory sensory and projection neurons have…