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Clinical Medicine Insights: Cardiology
Scopus
ISSN 1179-5468 · SAGE Publishing · 645 artikel di indeks
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Artikel Jurnal
Efficacy and Safety of Clopidogrel Versus Aspirin Monotherapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis
Background: Coronary artery disease (CAD) is the leading cause of death worldwide. After percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is recommended to reduce thrombotic events. This meta-analysis assesses the effectiveness of clopidogrel compared to aspirin…
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Artikel Jurnal
Evaluation of Neointimal Coverage After Guiding De-escalation of Antiplatelet Treatment in Patients with ST-elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention by Optical Coherence Tomography or Angiography: Rationale and Design of the DAPT-OCT Study
Background: Dual antiplatelet therapy (DAPT) de-escalation strategies including early switching from a potent P2Y 12 inhibitor to clopidogrel become attractive for patients with ST-elevation Myocardial Infarction (STEMI). It is unclear whether DAPT de-escalation after optical coherence tomography…
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Artikel Jurnal
Tirzepatide and the Cardiovascular Continuum: Metabolic, Cardiorenal and Heart Failure Evidence
Tirzepatide is a first-in-class, once-weekly dual GIP and GLP-1 receptor agonist approved for type 2 diabetes and obesity. Given the tight link between hyperglycemia, adiposity, and cardiovascular disease, tirzepatide has rapidly gained interest as a broader cardiometabolic intervention. This…
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Current State of Computed Tomography Derived Fractional Flow Reserve (FFR-CT) and Its Diagnostic Advantages
Coronary computed tomography angiography (CCTA) is widely used for noninvasive evaluation of coronary artery disease (CAD) and is highly sensitive for detecting anatomic coronary stenosis with a high negative predictive value. However, CCTA is limited in its ability to determine the physiological…
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Artikel Jurnal
Real-World Evaluation of Guideline-Directed Treatments in Patients With Obstructive Hypertrophic Cardiomyopathy in Germany
Background Obstructive hypertrophic cardiomyopathy (HCM) is defined by left ventricular hypertrophy with outflow tract obstruction. Despite clear guideline-directed medical therapy recommendations from the European Society of Cardiology (ESC), it remains unclear whether real-world treatment aligns…
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Toward Precision in Myocardial Injury Management: A Critical Synthesis and the C.A.L.I.B.R.A.T.E. Framework for Biomarker Integration
Cardiovascular diseases remain the leading cause of global mortality, necessitating precise strategies for diagnosing and managing myocardial injury. This review critically synthesizes the current biomarker landscape and proposes an integrative framework to address the significant translational…
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Artikel Jurnal
Complex Cyanotic Congenital Heart Disease in Pregnancy: Survival With Unrepaired Pulmonary Atresia and Ventricular Septal Defect – A Case Report
Pulmonary atresia with ventricular septal defect and systemic-to-pulmonary collateral supply is a severe conotruncal malformation characterized by complete right ventricular outflow tract obstruction, a large ventricular septal defect, and absence of a main pulmonary artery. Without surgical…
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Research Advances in Timing of Anticoagulant Therapy Following Cardioembolic Stroke
Cardioembolic stroke primarily results from thromboembolism caused by cardiac conditions such as atrial fibrillation, characterised by high recurrence rates, high rates of disability, and high mortality. Anticoagulation therapy is a key measure for the prevention of stroke recurrence, though the…
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Artikel Jurnal
Unveiling the Unknown: A Case Report of Undifferentiated Pleomorphic Sarcoma in the Heart
Undifferentiated pleomorphic sarcoma (UPS) of the heart is an exceedingly rare and highly aggressive tumor. We present the case of a 66-year-old male with a history of stage I prostatic acinar adenocarcinoma who was incidentally found to have a left atrial mass during cancer workup. Multimodal…
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Unsupervised Phenotyping of Atrial Fibrillation Using Variational Autoencoders in a Critical Care Cohort: The ATLAS-AF Study
Objective Atrial fibrillation (AF) is a heterogeneous disorder associated with substantial morbidity and mortality, yet management remains largely guided by traditional classifications and risk scores. We aimed to identify distinct AF phenotypes using variational autoencoder (VAE)-based…
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When Chronic Risk Meets Acute Strain: Sudden Cardiac Death and Cardiovascular Vulnerability in Firefighters
Cardiovascular disease remains the leading cause of line-of-duty mortality among firefighters. Sudden cardiac death occurs disproportionately during emergency operations, particularly fire suppression, suggesting an interaction between occupational stressors and underlying cardiovascular…
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Rheumatic Heart Disease in Pregnancy in Sub-Saharan Africa: A Case Series Emphasizing Gaps in Access to Definitive Care
Rheumatic heart disease (RHD) remains a major cause of maternal cardiovascular morbidity and mortality in low-resource settings, particularly among women of reproductive age. Physiological changes during pregnancy can unmask previously undiagnosed disease or precipitate decompensation in those with…
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Artikel Jurnal
Spatial Metabolic Profiling of Human Atrial Tissue in Atrial Fibrillation Using DESI-MSI: An Exploratory Pilot Study
Background Structural remodeling and atrial fibrosis are hallmarks of atrial fibrillation (AF), yet molecular alterations associated with atrial remodeling remain incompletely characterized, particularly their spatial distribution within human atrial tissue. Desorption Electrospray Ionization Mass…
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Artikel Jurnal
Sodium-Glucose Cotransporter-2 Inhibitors Following Acute Myocardial Infarction in Patients Without Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials
Background Sodium-glucose transporter 2 (SGLT2) inhibitors have shown significant cardiovascular benefits in heart failure (HF) patients with diabetes mellitus or chronic kidney disease. However, their safety and efficacy in non-diabetic patients without HF presenting with acute myocardial…
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Longitudinal Analysis of Heparin-Binding Protein (HBP) and Serum Amyloid a Protein (SAA) Versus Interleukin 6 (IL-6), C-Reactive Protein (CRP), and Procalcitonin (PCT) During Both the Acute Postoperative Period and Recovery at Three Months From Non-emergent Cardiac Surgery
Variability in novel inflammatory markers (HBP and SAA) post-surgery could indicate ongoing perioperative inflammation. This pilot cohort study collected blood from 99 patients undergoing elective cardiac surgery at baseline, 24 hours, 7 days, and 3 months post-surgery. Inflammatory markers (HBP…
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Artikel Jurnal
Overlap of Frailty and Depression and Its Association With Cardiovascular Disease: A Population-Based Study
Background Depression and frailty are prevalent geriatric syndromes. Their co-occurrence may define a phenotype of heightened cardiovascular disease (CVD). In Latin America the joint association of these syndromes with CVD has not been previously characterised. Objective To evaluate the association…
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Artikel Jurnal
Efficacy and Safety of Implantable Left Ventricular Assist Devices for Destination Therapy: A Peruvian Health Technology Assessment
Aim: To evaluate the efficacy and safety of the HeartMate 3 (HM3) left ventricular assist device (LVAD) as a destination therapy (DT) for patients with end-stage heart failure (HF) ineligible for transplantation, from a Peruvian healthcare perspective. Methods: A health technology assessment (HTA)…
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Artikel Jurnal
Why Men Fare Worse: Understanding Gender Disparities in Systemic Sclerosis-Associated Pulmonary Hypertension
Objective: This study investigates gender disparities in clinical outcomes among patients with systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH), focusing on cardiovascular events, right ventricular function, and survival. Introduction: PAH is a severe and life-threatening…