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Veterinary Research
Scopus
ISSN 1297-9716 · BMC · 1.500 artikel di indeks
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Artikel Jurnal
Transcriptomic insights into cultivation-driven virulence in Aeromonas spp.: a new approach to optimizing autogenous vaccines in aquatic veterinary medicine
Abstract Autogenous vaccines are a critical tool in aquaculture for managing bacterial diseases when commercial vaccines are unavailable or ineffective. To improve vaccine efficacy, this study explored how different cultivation conditions influence virulence gene expression in two major fish…
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Artikel Jurnal
Receptor identification and in vivo efficacy of a lytic phage vB_EcoStr-FJ63A against colistin-resistant Escherichia coli
Abstract Bacteriophages (phages), as natural predators of bacteria, represent promising alternatives to antibiotics. However, challenges such as narrow host range and insufficient pharmacokinetic and pharmacodynamic (PK/PD) studies restrict phage therapy. In previous work, we isolated Escherichia…
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Artikel Jurnal
Development of a bacterin–toxoid vaccine using a Korean isolate for protection against caseous lymphadenitis in goats
Abstract Caseous lymphadenitis (CLA), a chronic infectious disease caused by Corynebacterium pseudotuberculosis, remains a major concern in small ruminant populations owing to its persistent nature and impact on animal productivity. Despite the availability of commercial vaccines, their efficacy in…
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Artikel Jurnal
Comparative evaluation of histopathological lesions and viral antigen distribution in domestic pigs and wild boar inoculated intranasally with the highly virulent ASFV genotype II strain “Armenia 2007”
Abstract African swine fever (ASF) is a devastating viral disease that affects domestic pigs (Sus scrofa domesticus) and European wild boar (Sus scrofa scrofa). A previous study indicated that wild boar were more susceptible to ASF than pigs, with shorter incubation periods and earlier onset of the…
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Artikel Jurnal
From predisposition to recovery: field evidence of interactions between the gut microbiota and Brachyspira hyodysenteriae infection
Abstract Restrictions on antibiotics use have increased interest in the gut microbiota relationship to host health, particularly in enteric infections. The present field study, performed on two farms with endemic swine dysentery (SD) infection, characterises the faecal microbiota in 102 faecal…
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Artikel Jurnal
Host genetics, lung T-cell immunity, and laying activity determine the disease outcome in avian influenza virus-infected chickens
Abstract Avian influenza viruses pose a threat to both wild and domestic bird populations worldwide. In particular, chickens kept outdoors have contact with wild birds and thus an increased risk of infection with influenza viruses. Increasing use of high-performance chicken breeds in growing…
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Artikel Jurnal
Changes in the gill and gut microbiota of koi infected with carp edema virus
Abstract Carp edema virus (CEV) is a contagious pathogen affecting mostly the gills of common carp (Cyprinus carpio) and impairing the functions of this organ. Moreover, CEV was reported to cause stress activation and modulation of the hosts immune system. Last but not least, secondary bacterial…
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Artikel Jurnal
Activation of the ATM–Chk2 DNA damage response pathway by Newcastle disease virus enhances viral replication
Abstract Newcastle disease (ND), caused by virulent strains of the Newcastle disease virus (NDV), is a highly contagious disease that poses significant economic burdens on the global poultry industry. The DNA damage response (DDR) is a critical cellular mechanism that detects and repairs genomic…
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Artikel Jurnal
Brucella abortus infection exploits ZDHHC3-mediated STAT3 palmitoylation to regulate host responses and promote persistence
Abstract Brucella abortus, an intracellular bacterium, employs intricate mechanisms to manipulate host signaling for persistence. This study investigates the role of STAT3 palmitoylation in B. abortus-infected macrophages. We demonstrate that B. abortus infection induces STAT3 palmitoylation, which…
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Artikel Jurnal
The c-di-AMP binding protein NadD from Mesomycoplasma ovipneumoniae functions as a phosphodiesterase that inhibits host inflammatory responses
Abstract Cyclic dimeric adenosine monophosphate (c-di-AMP) is a second messenger commonly found in bacteria, particularly within the Firmicutes and Actinobacteria phyla, as well as in Archaea. Phosphodiesterase (PDE) is an enzyme that plays a crucial role in regulating the homeostasis of bacterial…
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Artikel Jurnal
Occurrence of diverse circoviruses in wild birds in Hungary
Abstract Circoviruses (CVs) infect a wide range of avian hosts, including domestic, ornamental and wild birds. The immunosuppressive effect of these viruses could make the host more susceptible to other pathogens. This study aimed to assess the potential hosts and genetic features of CVs or other…
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Artikel Jurnal
Experimental intranasal infection reveals broad tissue tropism of bovine coronavirus
Abstract Bovine coronavirus (BCoV) causes neonatal calf diarrhea, winter dysentery, and respiratory disease worldwide. However, its primary replication site remains uncertain, and systemic studies on tissue tropism are limited. We, therefore, intranasally inoculated colostrum-fed Holstein calves…
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Artikel Jurnal
The whole genome sequencing offers insights into the susceptibility to the foot-and-mouth disease virus carrier state
Abstract Foot-and-mouth disease virus (FMDV) establishes persistent infection in more than 50% of infected ruminants, irrespective of vaccination status, implicating potential contributions of host genetic variations to viral persistence. In this study, we conducted whole-genome resequencing of a…
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Artikel Jurnal
Identification of an altered gut microbiome and the protective effect of microbiome changer in prion diseases
Abstract Prion diseases are fatal and contagious brain disorders caused by a pathogenic prion protein (PrPSc) derived from the benign prion protein (PrPC). To date, there are no therapeutic substances to completely block prion diseases. Thus, the development of a therapeutic substance is necessary…
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Artikel Jurnal
Paclitaxel induces trained immunity via the GPR183–STING axis to enhance host defense against MRSA infection
Abstract Methicillin-resistant Staphylococcus aureus (MRSA) remains a major global health threat with limited prophylactic options. Trained immunity, characterized by nonspecific functional reprogramming of innate immune cells, offers a promising strategy for infection control. Here, we identify…
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Artikel Jurnal
Identification of two immunodominant and neutralizing linear B-cell epitopes exposed on the surface of the porcine deltacoronavirus spike protein
Abstract Porcine deltacoronavirus (PDCoV) is an enteropathogenic virus that causes severe diarrhea in pigs, particularly suckling piglets, and exhibits cross-species transmission with zoonotic potential. The S1 subunit of the viral spike (S) protein mediates cell entry and elicits neutralizing…
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Artikel Jurnal
Cathelicidin CATH-2 suppresses the NF-κB/ROS/NLRP3 signaling pathway via regulating mTOR-dependent autophagy during Streptococcus suis infection
Abstract Cathelicidin CATH-2 has been reported to exert potent anti-inflammatory activity in different species though neutralizing stimuli such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA). CATH-2 has been shown to inhibit Streptococcus suis (S. suis)-induced activation of dendritic…
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Artikel Jurnal
Outer membrane vesicles secreted by avian pathogenic Escherichia coli promote its survival within macrophages and systemic infection by inducing endoplasmic reticulum stress-mediated autophagy flux blockade
Abstract Avian pathogenic Escherichia coli (APEC) is an extraintestinal pathogenic Escherichia coli that primarily causes avian colibacillosis, leading to localized or systemic infections. Its persistent survival within host macrophages is a critical component of the systemic infection process. In…
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Artikel Jurnal
Distribution and characteristics of ceftiofur-resistant Escherichia coli throughout the broiler production chain in Korea
Abstract Ceftiofur, a third-generation cephalosporin, is classified as a critically important antimicrobial in both human and veterinary medicine, but its use in poultry has raised public health concerns due to an increase in resistant pathogens. This study comprehensively investigated the…
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