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Saudi Pharmaceutical Journal
Scopus
ISSN 1319-0164 · Springer · 1.916 artikel di indeks
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Artikel Jurnal
Essence of toxicology research to Saudi Arabia Vision 2030 and beyond: Current state and future perspectives
Abstract The Kingdom of Saudi Arabia has been making significant progress as part of its Vision 2030 to diversify its economy and reduce dependence on fossil fuels. Key components of this transformation include the development of a robust research and development (R&D) ecosystem and…
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Artikel Jurnal
Discovery of a novel VEGFR2 inhibitor using integrated structure-based docking study and functional validation: potential applications in targeted cancer therapy
Abstract Cancer remains a predominant cause of mortality worldwide, with conventional therapies often limited by adverse side effects and the development of drug resistance. Targeting receptor tyrosine kinases (RTKs), especially vascular endothelial growth factor receptor 2 (VEGFR2), presents a…
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Artikel Jurnal
Targeting the PI3K/AKT/mTOR signaling pathway in prostate cancer: Molecular dysregulation, therapeutic advances, and future directions
Abstract Prostate cancer (PCa) is among the most common malignancies and remains a leading cause of cancer-related mortality in men worldwide. One of the main drivers is the dysregulation of the downstream signalling machinery. The PI3K, AKT, and mTOR signalling pathways play a pivotal role in…
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Artikel Jurnal
Empagliflozin improves renal injury of diabetic nephropathy complicated with hyperuricemia through AMPK by promoting autophagy and inhibiting apoptosis
Abstract Objective This study aimed to investigate how empagliflozin alleviates renal injury in diabetic nephropathy with hyperuricemia by activating AMPK and regulating autophagy and apoptosis. Methods This study incorporated clinical renal tissue samples, diabetic-hyperuricemic mouse models, and…
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Artikel Jurnal
Comorbidities and mortality in colistin-resistant gram-negative infections among hospitalized patients in Qassim, Saudi Arabia
Abstract Colistin has served as a last-resort agent against multidrug-resistant Gram-negative bacilli (MDR-GNB). However, the emergence of resistance has substantially eroded its therapeutic value, particularly among hospitalized patients. Evidence regarding the clinical outcomes of…
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Artikel Jurnal
Risk of drug eruption associated with the use of tetracyclines, macrolides, and fluoroquinolones: real-world evidence from a pharmacovigilance study utilizing the FDA adverse event reporting system
Abstract Recently, concerns regarding the risk of drug eruption associated with the use of tetracyclines were raised by the United States Food and Drug Administration (U.S. FDA). Therefore, it is necessary to reevaluate this risk. This study aimed to quantify the signal of drug eruption associated…
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Artikel Jurnal
Pharmacogenomics knowledge, attitudes, and perceptions among pharmacists in the Asir Region, Saudi Arabia: a cross-sectional analysis
Abstract As personalized medicine progresses in Saudi Arabia, pharmacists endure a central role in pharmacogenomics (PGx) implementation. This cross-sectional study weighed the knowledge, attitudes, and perceptions (KAP) of pharmacists in the Asir region regarding PGx, a region with limited…
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Artikel Jurnal
Nanocarrier-mediated CRISPR-Cas delivery: a novel approach against antibiotic-resistant superbugs
Abstract Antibiotic resistance (ABR) is a leading cause of death and a major public health threat globally. Without appropriate interventions, annual ABR-associated deaths have been projected to reach 10 million by 2050 worldwide. Hence, it is critical to develop novel therapeutic interventions…
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Artikel Jurnal
Virtual bioequivalence-guided PBBM prediction for ibuprofen/diphenhydramine citrate tablets: impact of dissolution variability and clinical standard development
Abstract This study aimed to integrate in vitro dissolution testing, in vivo pharmacokinetic (PK) studies, and computational simulation to develop a physiologically based biopharmaceutics model (PBBM) for fixed-dose combination ibuprofen/diphenhydramine citrate tablets, thereby evaluating…
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Artikel Jurnal
Regional research priorities for medication safety and pharmacovigilance in gulf cooperation council countries: a modified Delphi consensus study
Abstract Adverse drug reactions (ADRs) and medication errors remain major global threats to patient safety. Although Gulf Cooperation Council (GCC) countries have advanced medication safety and pharmacovigilance programs, research priorities remain fragmented and lack expert consensus. To establish…
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Artikel Jurnal
Bridging the clinical trial gap in Saudi Arabia: a multi-stakeholder conference-based consensus on strategic initiatives for global competitiveness and patient inclusion
Abstract Background The clinical trial ecosystem of Saudi Arabia has advanced significantly, with innovative industry-sponsored clinical trials (iCTs) growing by 27% from 2018 to 2023, reaching 51.4% in the first half of 2025. However, the Kingdom remains underrepresented in global research. This…
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Artikel Jurnal
Gut microbiota modulation of systemic immunity and cancer immunotherapy: mechanisms, evidence, and therapeutic implications
Abstract The gut microbiota plays a critical role in regulating systemic immune responses and has emerged as a key determinant of therapeutic efficacy and toxicity in cancer immunotherapy. Accumulating evidence indicates that specific microbial taxa and microbiota-derived metabolites modulate…
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Artikel Jurnal
Adherence to evidence-based guidelines for the management of candiduria in a tertiary care center in Riyadh: A retrospective cross-sectional study
Abstract According to the Infectious Disease Society of America (IDSA) 2016 guidelines for the management of candidiasis, the presence of Candida in the urine in asymptomatic patients is usually a colonization rather than an infection, which does not require antifungals treatment. This study aims…
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Artikel Jurnal
Developing a medical-device formulary for council of health insurance beneficiaries in Saudi Arabia: stakeholder challenges and policy recommendations
Abstract Ensuring equitable access to dispensed-to-patient (DTP) medical devices is an important policy priority for health insurance systems. This mixed-method study examined stakeholder perspectives on barriers and policy priorities for developing a DTP medical-device formulary for health…
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Artikel Jurnal
LC-ESI-TOF–MS profiling and protective effects of Psidium cattleianum extract against gentamicin-induced nephrotoxicity in rats via Nrf2/HO-1 and caspase-dependent pathway
Abstract Drug-induced nephrotoxicity is an alarming trigger for kidney injury. It is linked to a high rate of illness and fatality, with limited treatment options. Herein, we aimed to unravel the phytochemical profile and understand the protective activity of the aqueous methanolic extract (AME) of…
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Artikel Jurnal
Biogenic chitosan-encapsulated Cu/ZnO nanocomposite surface coating inhibits MDR Pseudomonas aeruginosa biofilm establishment on orthopedic implants
Abstract Orthopedic implant-associated infections (IAIs), predominantly caused by Pseudomonas aeruginosa, represent a major clinical challenge due to antibiotic resistance and biofilm formation, which together contribute to their chronic nature. This research presents a biogenic biofilm-resistant…
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Artikel Jurnal
Rhein and its derivatives: potential anti-tumor drugs and corresponding targeted mechanism
Abstract Cancer remains a major global health threat with high morbidity and mortality, and clinical treatment is plagued by drug resistance, poor efficacy and severe side effects, driving the search for novel anti-tumor agents from natural products. Rhein, a natural anthraquinone abundant in Rheum…
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Artikel Jurnal
A real-world, bottom-up cost of illness analysis of type 2 diabetes mellitus from a tertiary hospital in Saudi Arabia
Abstract Type 2 diabetes mellitus (T2DM) is a major contributor to global morbidity, mortality, and healthcare expenditure. In the context of Saudi Arabia, it is concerningly notable that the prevalence of T2DM is particularly high and rising. Existing cost estimates have previously relied rely on…
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Artikel Jurnal
Formononetin attenuates glucocorticoid-induced osteoporosis via multiple osteoimmunological pathways: evidence from zebrafish and network pharmacology
Abstract Osteoporosis is a prevalent metabolic bone disease that requires multi-target therapeutic strategies. Formononetin (FMN), a bioactive isoflavone derived from Astragalus species, has shown potential in promoting bone health; however, its systemic mechanisms remain poorly understood. In this…
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Artikel Jurnal
Phytochemicals with potential NMDAR-inhibitory activities: a review of neuroprotective mechanisms against excitotoxicity
Abstract The N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors in the central nervous system (CNS) that play a crucial role in synaptic plasticity, learning, and memory. However, NMDAR overstimulation is a critical pathological feature in neurodegenerative diseases, stroke…
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