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Journal of Pharmacological Sciences
Scopus
ISSN 1347-8613 · Elsevier · 3,173 articles in the index
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Journal Article
Wenyang Jiedu Huayu Formula alleviates acute-on-chronic liver failure by modulating gut microbiota composition and restoring intestinal–hepatic homeostasis
Acute-on-chronic liver failure (ACLF) is a life-threatening condition associated with systemic inflammation, hepatic necroptosis, and disrupted gut-liver axis signaling. Wenyang Jiedu Huayu Formula (WYJDHY), a traditional Chinese medicine formulation, was investigated for its potential therapeutic…
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Journal Article
Benzamil-induced cytotoxicity in non-small cell lung cancer is associated with mitochondrial damage, mitochondrial elongation, and altered XIAP signaling
Despite newly introduced treatment options, the 5-year survival rate for non-small cell lung cancer (NSCLC) remains below 20%, indicating a remaining need for new treatment strategies. Benzamil (BZ) has demonstrated inhibitory effects on brain tumors and osteosarcoma; however, its effects on NSCLC…
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Journal Article
Melatonin ameliorates diabetic retinopathy by inhibiting PANoptosis via the LncSNHG5/miR-26a-5p/Hippo signaling axis
Background: High glucose-induced injury to human retinal endothelial cells (HRCCs) is closely associated with retinal disorders, and melatonin has potential protective effects. However, its underlying mechanism remains unclear. Methods: human retinal endothelial cells (HRCCs) were exposed to high…
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Journal Article
Nobiletin differentially regulates muscarinic and nicotinic receptor–mediated ERK signaling
Nobiletin, a citrus polymethoxyflavone with neuroprotective properties, activates extracellular signal–regulated kinase 1/2 (ERK1/2); however, its effects on cholinergic receptor–mediated ERK signaling remain unclear. This study aimed to investigate the effects of nobiletin on the muscarinic and…
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Journal Article
Glucose metabolic responses to psychological stress vary across developmental stages in mice
Cyclic vomiting syndrome (CVS) with acetonemia is a representative psychosomatic disorder triggered by psychological stress. In most cases, patients experience symptoms of ketoacidosis, including vomiting during childhood, which typically resolve by approximately 10 years of age. Although abnormal…
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Journal Article
Finerenone improves vascular function in association with reduced aortic sodium content in aldosterone/salt-loaded uninephrectomized rats
Mineralocorticoid receptor (MR) overactivation and high salt intake drive vascular dysfunction, characterized by endothelial impairment and stiffening. While the novel non-steroidal MR antagonist (MRA), finerenone improves cardiovascular outcomes in patients with heart failure, its specific effects…
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Journal Article
Network pharmacology and metabolomics reveal the mechanism of Qi Feng Gu Biao Granules against chronic bronchitis-related cough: a core role for the AGEs/RAGE pathway
Cough is a prominent and often persistent manifestation of chronic bronchitis (CB) that is frequently difficult to resolve. While Qi Feng Gu Biao Granules (QFGBG) is a traditional Chinese medicine commonly used to treat CB, its pharmacological basis for CB-related cough remains unclear.This study…
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Journal Article
Cholinergic neurons in the dorsal motor nucleus of the vagus contribute to vagally mediated cardiovascular responses through a putative pathway involving the nodose ganglion
The baroreflex plays an important role in maintaining cardiovascular homeostasis. Although the central pathways mediating baroreflex responses have been characterized, the mechanisms underlying modulation of vagal afferent signaling remain incompletely understood. We hypothesized that a neural…
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Journal Article
Inhibition of ceramide synthase 5 ameliorates pulmonary fibrosis via suppression of TGF-β/Smad signaling
The TGF-β/Smad signaling pathway plays a central role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and is modulated by sphingolipid metabolism. Ceramide, a key intermediate in this pathway, is synthesized in various acyl-CoA chain lengths by ceramide synthases (CerS). However, the…
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Journal Article
Role of Tinospora cordifolia (Willd.) Hook. F. in neurological disorders: A comprehensive review and network pharmacology-based analysis
Tinospora cordifolia (Willd.) Hook. F. & Thomson (T. cordifolia), commonly known as Giloy or Guduchi, is widely recognized traditional medicinal herb for its potent nootropic and therapeutic properties. While extensive preclinical studies have demonstrated its diverse pharmacological potential…
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Journal Article
Chronic glucocorticoid exposure disrupts lactate homeostasis and hippocampal neurogenesis by reducing cerebrovascular monocarboxylate transporter 1, leading to behavioral abnormalities in mice
Prolonged glucocorticoid elevation is strongly associated with brain dysfunction and the pathogenesis of stress-related disorders, including several psychiatric disorders. Elevated lactate levels have been reported in the brains of patients with psychiatric disorders and animal models of chronic…
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Journal Article
TRPC6-mediated calcium signaling is involved in T2DM-induced hepatic steatosis and fibrosis and the modulation of ginsenoside Rg1
Hepatic steatosis and fibrosis represent major complications of type 2 diabetes mellitus (T2DM) with limited therapeutic options. Ginsenoside Rg1, a bioactive constituent of Panax ginseng, exhibits hepatoprotective properties, but its mechanism in diabetic liver injury remains unclear. The…
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Journal Article
Population pharmacokinetic study of meropenem in patients with severe infections and Monte Carlo simulation of the efficacy under different dosing regimens
Background: Meropenem is a first-line carbapenem for severe Gram-negative infections, but its pharmacokinetics varies markedly in patients with severe infections. Individualized dosing guided by population pharmacokinetic (PPK) modeling is essential to optimize efficacy and limit resistance…
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Journal Article
Valproic acid alleviates abdominal irradiation-induced intestinal injury in mice through anti-inflammatory and barrier-preserving effects
Radiation-induced intestinal injury is a major complication of abdominal radiotherapy; however, effective protective strategies remain limited. To overcome the systemic limitations of total body irradiation models, we developed a localized abdominal irradiation (ABI) mouse model, enabling targeted…
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Journal Article
Human blood–brain barrier spheroid models for the evaluation of drugs targeting brain vascular inflammation
The blood–brain barrier (BBB), primarily formed by brain microvascular endothelial cells (BMECs), restricts substance entry into the brain. BBB inflammation, involving barrier dysfunction and immune cell recruitment, contributes to neurological diseases and represents a therapeutic target. In this…
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Journal Article
SPARC induction and correlation with inflammation and fibrosis in a mouse model of alkali-induced abdominal adhesions
Postoperative abdominal adhesions can cause several complications, such as intestinal obstruction, female infertility, and chronic pelvic pain. By alkaline cauterization of the cecum, we established a mouse abdominal adhesion model to investigate the roles of secreted protein acidic and rich in…
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Journal Article
Ginsenoside RD2 inhibits gastric cancer progression by suppressing TRIM46-mediated DUSP1 ubiquitination and modulating the ERK signaling pathway
Background: Ginsenoside RD2, a bioactive compound derived from ginseng, has been shown to possess various biological activities, including potential anti-cancer effects. However, its therapeutic efficacy and molecular mechanisms, particularly in gastric cancer (GC), remain inadequately understood…
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Journal Article
Isoschaftoside protects against acetaminophen-induced acute liver injury by suppressing TLR4/NF-κB pathway activation
Acetaminophen (APAP) overdose is a leading cause of acute liver injury, yet effective protective therapies remain limited. Isoschaftoside (Iso) is a flavonoid phytochemical with reported antioxidant and anti-inflammatory activities, but its role in APAP-induced liver injury remains unclear. Here…
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Journal Article
Low-molecular-weight chondroitin sulfate attenuates hyperalgesia via immunomodulation of macrophage polarization
Osteoarthritis is the most common form of arthritis, for which effective and safer treatments are needed. While chondroitin sulfate (CS) has been reported to exert analgesic effects, its cellular targets and immunomodulatory mechanisms remain unclear. This study aimed to clarify the effects of…
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