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Endocrine Journal
Scopus
ISSN 1348-4540 · The Japan Endocrine Society · 371 articles in the index
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Journal Article
Consensus on the diagnosis of Cushing’s disease: a collaborative statement from the Korean Endocrine Society and Japan Endocrine Society
Cushing’s disease (CD) is a rare but serious endocrine disorder caused by excessive cortisol secretion due to adrenocorticotropic hormone–secreting pituitary tumors. Despite recent developments in diagnostic criteria and treatment options, CD remains associated with substantial comorbidities and…
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Journal Article
Clinical practice guidelines for the management of differences of sex development in Japan
Differences of sex development (DSD) are congenital conditions in which chromosomal, gonadal, and anatomical sex characteristics are discordant with typical male or female development. These clinical practice guidelines provide evidence-based recommendations for the diagnosis and management of…
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Journal Article
Diagnostic criteria for acquired hypothalamic obesity – international expert guidance document
Acquired hypothalamic obesity (aHO) presents as rapid, clinically relevant, and persistent weight gain due to hypothalamic damage, and leads to significant morbidity/mortality and decreased quality of life. Causes include craniopharyngioma and other space-occupying lesions, neurosurgical…
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Journal Article
Effects of maternal commercial supplementation on 25-hydroxyvitamin D levels in newborns: a retrospective cohort study in a single center, Saitama, Japan, 2022–2023
Vitamin D (VD) insufficiency in pregnant women is a serious health problem worldwide. To prevent VD insufficiency during pregnancy, several guidelines recommend 600 IU/day VD for all pregnant women. In Japan, no national guidelines for preventing VD insufficiency have been implemented, and no study…
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Journal Article
Palopegteriparatide in Japanese adults with hypoparathyroidism: 52-week results from the phase 3 PaTHway Japan trial
PaTHway Japan is an ongoing, phase 3, multicenter, single-arm, open-label trial comprised of a 26-week efficacy period with an extension period through week 182 designed to demonstrate the efficacy, safety, and tolerability of palopegteriparatide in Japanese individuals with hypoparathyroidism…
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Journal Article
Selective β3-adrenoceptor agonist reduces energy intake and elevates GDF15 levels in lean and diet-induced obese mice
β3-Adrenoceptors (β3ARs) are expressed in the adipose tissue, the brain, and the bladder. In rodents, selective β3AR agonists have been shown to reduce normal chow intake through central and peripheral mechanisms. However, the impact of β3AR agonists on nutritional balance, as well as the relative…
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Journal Article
Dietary fiber density as an important modifying factor in the association between rice intake and obesity in Japanese type 2 diabetes outpatients: a sex and age-stratified cross-sectional investigation (JDDM 80)
A meta-analysis of cohort studies found a positive association between white rice consumption and chronic disease risk, particularly in women. However, the association between rice intake and obesity remains inconsistent across populations. We aimed to examine the relationship between rice intake…
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Journal Article
Sarcopenia and body temperature—the significance of interorgan metabolic networks in skeletal muscle atrophy
The skeletal muscle plays a key role in thermogenesis and energy homeostasis in endotherms. Therefore, reduced skeletal muscle mass and function are closely associated with health disorders such as obesity and hypothermia. In humans, inactivity and nutritional deficiencies can lead to skeletal…
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Journal Article
Effect of body mass index change on the development of diabetes mellitus
A high body mass index (BMI) is associated with the onset of diabetes mellitus (DM). However, evidence regarding the association between changes in BMI and DM onset is limited, and the effect of annual BMI (kg/m2/year) change on DM onset is unknown. Therefore, we assessed the effects of changes in…
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Journal Article
Chromosomal and hormonal factors involved in human sexual dimorphism
Males and females show significant differences in body structure, typical behavior, average life expectancy, and disease susceptibility. This review article introduces the current understanding and recent findings on the factors that lead to sexual dimorphism. First, recent studies have shown that…
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Journal Article
Association of physical activity and sedentary time with risk of non-alcoholic fatty liver disease in adults with and without diabetes mellitus
This study examined the association of physical activity (PA) and sedentary time (ST) with the risk of non-alcoholic fatty liver disease (NAFLD) in adults with and without diabetes mellitus (DM). The study used data from the 2017–2020 National Health and Nutrition Examination Survey and conducted…
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Journal Article
Genetic screening of the insulin-like growth factor 1 receptor gene in children born small for gestational age: the continuing importance of insulin-like growth factor 1 signaling
Children born small for gestational age (SGA) who fail to experience catch-up growth often remain short-statured with heterogeneous etiologies, including genetic factors. This study aimed to investigate Insulin-like Growth Factor 1 Receptor (IGF1R) gene alterations and their clinical relevance in…
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Journal Article
A correlation analysis between TyG-derived indices and diabetes mellitus: based on the NHANES database
Diabetes mellitus (DM) is a key global public health issue with rising incidence. The triglyceride-glucose (TyG) index has been widely applied to assess insulin resistance and metabolic abnormalities in recent years. However, the relation of the TyG index with DM is elusive when combined with…
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Journal Article
Long-term effectiveness and safety of daily growth hormone therapy in Japanese children with Noonan syndrome: a post-marketing surveillance study
Reports on long-term safety and effectiveness of daily GH replacement therapy in Japanese children with short stature due to Noonan syndrome (NS) are limited. This post-marketing, prospective, non-interventional study (ClinicalTrials.gov NCT03435627) evaluated the long‑term safety and effectiveness…
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Journal Article
Metachronous multiple insulinomas in oculo-facio-cardio-dental syndrome harboring a novel BCOR deletion: a case report with review of literature
Oculo-facio-cardio-dental (OFCD) syndrome is a rare X-linked dominant disorder caused by pathogenic variants in the BCOR gene and is characterized by distinctive craniofacial, ocular, cardiac, and dental abnormalities. Although OFCD syndrome is a well-defined developmental disorder, its association…
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Journal Article
Real-world optimization of cutoff values for enzyme immunoassay-based plasma-free fractionated metanephrines for the diagnosis of pheochromocytoma and paraganglioma: a multicenter retrospective study
Pheochromocytoma and paraganglioma (PPGL) require sensitive biochemical screening to prevent delayed or missed diagnoses. In Japan, plasma-free metanephrines (pMN/pNMN) measured using enzyme immunoassay have been covered by national insurance since 2019; however, the real-world diagnostic…
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Journal Article
Effect of social jetlag on metabolic syndrome varies by body mass index: evidence from Taiwan Biobank
Social jetlag (SJL), the misalignment between biological and social time, has been linked to adverse metabolic outcomes. However, the effect of body mass index (BMI) on this association remains unclear, particularly in Asian populations. This cross-sectional study utilized data from the Taiwan…
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Journal Article
Inter- and intratumoral heterogeneity of aldosterone-producing adenomas: recent advances and clinical implications
Primary aldosteronism is the most common form of secondary hypertension, and aldosterone-producing adenoma (APA) is the most prevalent surgically curable subtype of primary aldosteronism. Over the past decade, the identification of recurrent somatic mutations, most notably in KCNJ5, has transformed…
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Journal Article
Recurrent Cushing’s disease due to postoperative seeding of tumor cells in the sphenoid sinus: a case report with review of the literature
Recurrent Cushing’s disease is most commonly caused by residual or newly developed pituitary neuroendocrine tumor (PitNET) tissue within the sellar region. Extrasellar recurrence due to postoperative tumor cell seeding is exceedingly rare. We report the unique case of a 30-year-old woman who…
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Journal Article
Associations of stress hormones, autonomic function, and endothelial function in patients with diabetes
Endothelial dysfunction is an early feature of diabetic vascular injury. Stress-induced activation of the hypothalamic–pituitary–adrenal (HPA) axis, together with autonomic imbalance, may contribute to endothelial dysfunction. However, its clinical relevance in diabetes remains to be fully…