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Brazilian Journal of Medical and Biological Research
Scopus
ISSN 1414-431X · Associação Brasileira de Divulgação Científica · 5,760 articles in the index
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Time of day is associated with federal highway accidents in Brazil
According to the most recent Global Status Record of Road Traffic, the number of road traffic deaths continues to rise. The risk of a road traffic death is more than 3 times higher in low-income countries than in high-income countries. However, the effect of time of day on road accidents is barely…
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Spatial and epidemiological mapping of tuberculosis on an Amazon island: effect of the COVID-19 pandemic
With the emergence and rise of the COVID-19 pandemic in 2020, many health services were interrupted and reallocated due to system overload. Tuberculosis (TB) care was one of the affected services during this period, especially in regions with greater social vulnerabilities. Thus, this study aimed…
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An overview on central nervous system tuberculosis (CNS-TB) focusing on cognitive impairments
One of the most serious clinical manifestations of tuberculosis (TB) is the central nervous system (CNS) presentation, which results in neurological disorders and cognitive impairments that may lead to reduced social skills. Few studies have assessed TB neuropsychological symptoms after infection…
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Interplay between volemic balance and the intestinal tract: insights on biomarkers and diagnostic tests used to assess intestinal morphofunctional barrier
Volemic control is essential for maintaining tissue perfusion and fluid homeostasis, with cardiorenal and endothelial mediators regulating intravascular composition, often impaired in pathological states. Notably, intestinal epithelial cells are highly sensitive to volume fluctuations, resulting in…
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Subclinical atherosclerosis in rheumatoid arthritis: a case cohort analysis from ELSA-Brasil
This study evaluated prevalence, incidence, and progression of carotid intima-media thickness (cIMT) and carotid artery plaques (CAP) in rheumatoid arthritis (RA) patients compared with controls during 8 years of follow-up. A case-cohort analysis of data from the ELSA-Brasil cohort was conducted…
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Cellular and molecular immunomodulatory potential of red wine polyphenols in apical periodontitis
This in vitro and in vivo study assessed dealcoholized red wine (DRW) effects on cytokine profile in macrophage (MQ)-periodontal ligament fibroblast (PDLFs) co-cultures and its impact on blood parameters, inflammatory/bone markers, cytokine expression, and periapical bone loss in rat apical…
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IL-6 and TGF-β1 as biomarkers of schistosomiasis-associated pulmonary hypertension in a murine model
Schistosomiasis can lead to vascular damage resulting in pulmonary arterial hypertension (PAH). Although its pathophysiology remains unclear, cytokine imbalance is known to play a key role. This study aimed to evaluate serum mediators in association with hemodynamic, echocardiographic, and…
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Complex dynamics of glutamate-induced calcium responses in astrocytes from the nucleus of the solitary tract of mice
Astrocytes play critical roles in the physiological responses of the central nervous system (CNS). Located near pre- and postsynaptic sites, they detect released neurotransmitters and gliotransmitters that modulate neuronal function. Astrocytic responses to neurotransmitter excitation often involve…
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Bakterion: development of a serious game for microbiology education
Microbiology education is traditionally lecture-based, with few studies exploring active methodologies such as serious games. In this context, this study aimed to develop a serious card game, ‘Bakterion', as a teaching tool for antimicrobial education. The game was designed based on Game Design…
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Expression of MIR155HG, LOC283856, KIAA0125, and LOC100190986 as potential prognostic and predictive biomarkers for breast cancer
Accumulating evidence has pointed out that the altered expression of long non-coding RNAs (lncRNAs) is involved in the physiopathology of breast cancer (BC). However, the role of lncRNAs in BC progression remains poorly understood. Here, we evaluated cDNA microarray data from a previous study from…
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Precision application of target-controlled infusion of esketamine combined with sufentanil in anesthesia for thoracoscopic surgery and its effect on hemodynamics, postoperative pain, and safety
We aimed to expound the precise application of target-controlled infusion (TCI) of esketamine combined with sufentanil in anesthesia for video-assisted thoracoscopic surgery (VATS) and its effect on hemodynamics, postoperative pain, and safety. Eighty patients scheduled for thoracoscopic procedures…
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Therapeutic potential of p-cymene in mitigating alcohol-induced damage in umbilical cord-derived mesenchymal stem cells through restoration of Nanog, VEGF, and antioxidants levels; in silico and in vitro approaches
Human stem cells can divide and differentiate into various cell types. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are multipotent cells with high regenerative, anti-inflammatory, and immunomodulatory properties. Ethanol, the main component of alcoholic beverages, induces cytotoxicity…
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Brief results of heterotopic xenotransplantation of meningioma into the peritoneum of Wistar rats: an experimental study
Meningiomas are the most common primary intracranial tumors, and xenotransplantation models help to study their behavior and test therapies. This research developed a model implanting WHO grade I meningothelial meningioma into the peritoneum of immunosuppressed rats, comparing it to subcutaneous…
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Drug-related proteinuria: a vigilance analysis based on the FAERS database
Proteinuria is a prevalent and significant adverse response (ADR) associated with numerous pharmaceuticals, and we employed the online public FDA Adverse Event Reporting System (FAERS) database to investigate a cohort of medications that may induce this ADR. This analysis aimed to identify and…
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Exploring the causal impact of mitochondrial dysfunction on epilepsy: a mendelian randomization study
Mitochondrial dysfunction contributes critically to epileptogenesis. Therefore, identifying key mitochondrial function-associated genes in epilepsy may provide novel insights into its pathogenesis. We employed expression quantitative trait loci (eQTLs) and Mendelian randomization analyses to assess…
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Disulfidptosis modification patterns are involved in the immune microenvironment regulation of septic acute respiratory distress syndrome
Disulfidptosis is a new form of programmed cell death. However, there is limited information available regarding the impact of disulfidptosis on septic acute respiratory distress syndrome (ARDS). The 16 disulfidptosis-related genes (DRGs) were collected from a previous study. Gene expression data…
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Effects of combined trunk stretching and lumbar stabilization exercises for chronic non-specific low back pain: a randomized clinical trial
This study aimed to compare the effectiveness of combining trunk stretching with lumbar segmental stabilization versus exclusively performing lumbar segmental stabilization exercises for treating chronic nonspecific low back pain (CNLBP). Thirty-four CNLBP subjects were randomized into two groups…
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Metformin attenuates fructose-induced pulmonary fibrosis, possibly through the involvement of the TRPC6 channel
Pulmonary fibrosis is a chronic, progressive, fatal lung disease characterized by abnormal lung tissue repair and intense collagen accumulation in the lungs. Despite intensive efforts, no specific treatment has been found. The aim of this study was to investigate the effects of a high-fructose diet…
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Unveiling preeclampsia: diagnostic value and potential molecular mechanisms of abnormally methylated immune-related genes
Preeclampsia (PE) is a life-threatening obstetric complication, and DNA methylation and immune system disorders play a key role in its development. This study aimed to explore the potential mechanisms and values of abnormally methylated immune-related differentially expressed genes (DEGs) in PE…
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How sexual behavior in male rats is inhibited by repeated maternal separation during early postnatal development
Perinatal stress can have lasting effects on hormone regulation and behavior. An association between maternal separation and depressive illness is well established. The present study was undertaken to investigate the effects of maternal separation on both motivational and consummatory measures and…
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