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Cellular and Molecular Life Sciences
Scopus
ISSN 1420-9071 · Springer · 593 artikel di indeks
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Artikel Jurnal
Inflammation-induced LncRNA SNHG1 orchestrates spermatogonium development in non-obstructive azoospermia via IL-17 A signaling pathway
Abstract Non-obstructive azoospermia (NOA) is a critical subtype of male infertility associated with inflammation. However, the molecular mechanisms underlying this phenomenon remain poorly understood. This study investigated the role of the inflammation-activated long non-coding RNA SNHG1 in NOA…
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Artikel Jurnal
Mitochondrial and lipid metabolism rewiring during HEV infection
Abstract Hepatitis E virus (HEV), a leading cause of acute and chronic viral hepatitis, poses a persistent global health challenge. A deeper mechanistic understanding of virus–host interactions is critical for identifying therapeutic targets to mitigate HEV-associated disease. In this study, we…
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Artikel Jurnal
Super enhancer-driven LINC01013 mediates hypoxia-induced mitochondrial dysfunction by HSPA9 to determine pulmonary arterial smooth muscle cell fate
Abstract Super-enhancers (SEs) typically govern the expression of critical genes in the maintenance of cell identity. Recent advances suggest mitochondrial dysfunction contributes to pulmonary artery smooth muscle cell (PASMC) proliferation and inflammation in pulmonary hypertension (PH). However…
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Artikel Jurnal
CAP1-Mediated m6A modification of RRM2 suppresses tumor-associated M2 macrophage polarization and colorectal cancer growth
Abstract Colorectal cancer (CRC) progression is critically regulated by dynamic interactions between tumor cells and tumor-associated macrophages (TAMs), which shape the immuno-suppressive tumor microenvironment. In this study, we identify CAP1 as a novel regulator of this crosstalk through its…
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Artikel Jurnal
Hsa_circ_PCNT sponges hsa-miR-133b to promote SHH medulloblastoma via TAGLN2
Abstract Background Medulloblastoma (MB), the predominant pediatric malignant brain tumor, remains poorly characterized in terms of its molecular drivers. The lack of reliable early diagnostic biomarkers and effective therapeutic targets continues to pose significant clinical challenges. Recent…
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Artikel Jurnal
Microbiome composition modulates the lethal outcome of Drosophila A virus infection
Abstract Host-associated microbiomes can strongly influence viral infection outcomes, yet how minor variations in commensal bacterial composition modulate viral pathogenesis remain poorly understood. Here, we used Drosophila melanogaster to investigate how bacterial microbiome composition affects…
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Artikel Jurnal
Dragonfly red opsins share a common tuning mechanism with mammalian red opsins and further enhancement of near-infrared sensitivity
Abstract Some animals, such as primates and insects have color vision including sensitivity to red light (red vision). Red vision is basically achieved through opsins sensitive to the red region (red opsins), which independently evolved in different lineages. In dragonfly red vision, which is known…
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Artikel Jurnal
Single-Cell transcriptomic analysis reveals distinct cellular and molecular signatures of human oral mucosa and skin
Abstract Oral mucosal wounds heal faster and with minimal scarring compared to skin injuries, yet the underlying mechanisms remain poorly understood. To explore the cellular and molecular basis of this difference, we performed single-cell RNA sequencing (scRNA-seq) on paired, uninjured human oral…
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Artikel Jurnal
CA9+ cancer-associated fibroblasts cooperate with SPP1+ tumor-associated macrophages driving immune resistance in triple-negative breast cancer
Abstract Background Triple-negative breast cancer (TNBC) is a highly invasive and refractory subtype of breast cancer. Despite the promise of immune checkpoint blockade (ICB) therapy, response rates remain limited. The immune resistance driven by the tumor microenvironment has not yet been…
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Artikel Jurnal
RRx-001 ameliorates astrocyte pyroptosis by regulating LCN2-NLRP3 inflammasome activation in an MPTP-induced parkinson’s disease mouse model
Abstract Parkinson’s disease (PD) is characterized by progressive neurodegeneration closely linked to neuroinflammation and oxidative stress-induced damage and is characterized by the loss of dopaminergic (DAergic) neurons and the inflammatory response associated with glial cells. RRx-001 (RRx…
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Artikel Jurnal
B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis
Abstract N6-methyladenosine (m6A), the most prevalent RNA modification, plays a pivotal role in regulating mRNA metabolism and cellular processes such as immune responses. Although the m6A methyltransferase METTL3 is known to regulate T-cell homeostasis and influence experimental autoimmune…
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Artikel Jurnal
Exiting the ground state: the broad spectrum of cell fates accessible from naïve human pluripotent stem cells
Abstract Naïve human pluripotent stem cells (hPSCs) represent an in vitro analog of the pre-implantation epiblast – the founder tissue of the embryo proper. A widely held assumption, based on prior studies in the mouse system, was that naïve hPSCs are restricted in their differentiation potential…
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Artikel Jurnal
The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylation
Abstract Glycolytic reprogramming is closely associated with chronic kidney disease (CKD) progression. However, the role and mechanism of phosphofructokinase muscle type (PFKM), a core rate-limiting enzyme in glycolysis, in renal fibrosis remain unclear. This study analyzed Gene Expression Omnibus…
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Artikel Jurnal
Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models
Abstract Alpha‑synuclein (α‑syn) overexpression models are widely used to unravel the molecular mechanisms of Parkinson’s disease (PD), particularly in light of the dose-dependent transition between its physiological and toxic roles. However, existing systems rely on inducible expression, lack…
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Artikel Jurnal
FOXK1 induced upregulation of KIF20A promotes hepatocellular carcinoma progression via Wnt/β-Catenin/EMT signaling
Abstract Liver cancer ranks sixth in incidence and third in mortality worldwide, with hepatocellular carcinoma (HCC) accounting for 90% of cases. Kinesin family genes (KIFs) have been implicated in HCC progression, but their specific roles remain unclear. Here, using multiple transcriptomic…
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Artikel Jurnal
CD177+ neutrophils alleviate acute pancreatitis-associated lung injury by protecting colonic barrier and restoring gut microbiota
Abstract Altered neutrophil infiltration and function are associated with the deterioration of acute pancreatitis (AP) and even AP-associated lung injury. Although CD177 is a marker of neutrophil activation, its role in AP remains largely unknown. To determine whether ablation of Cd177 could…
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Artikel Jurnal
ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of TGM2, and synergy with ALDH6A1
Abstract Head and neck squamous cell carcinoma (HNSC) ranks among the most common malignancies globally, with ALDH2 mutations linked to elevated disease risk. This study delineates the tumor-suppressive functions of ALDH2, examining its enzymatic activity, post-translational modifications…
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Artikel Jurnal
Postnatal reduction of eIF4E overexpression in D1-SPNs ameliorates KCNQ channel dysfunction, hyperexcitability and ASD-like behaviours
Abstract An imbalance between the direct and indirect pathways of the striatum has been linked to the pathophysiology of autism spectrum disorder (ASD), manifesting as repetitive behaviours and hyperactivity. We have investigated cell-specific dysfunctions in spiny projection neurons (SPNs) in a…
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Artikel Jurnal
RFFL-mediated protein quality control limits functional rescue of TRID-CFTR modulator combination therapy for cystic fibrosis nonsense mutations
Abstract Cystic fibrosis (CF) is a monogenic disorder caused by mutations in the CFTR gene, which encodes a cAMP-regulated anion channel at the apical plasma membrane (PM) of epithelial cells. CFTR modulators have recently been approved as effective therapies for folding-defective mutations…
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Artikel Jurnal
Lnc1267-hnRNP U interaction promotes radioresistance by inhibiting apoptosis via attenuated RelA/p65 Ser536 phosphorylation
Abstract Radiotherapy efficacy is frequently limited by tumor radioresistance, with dysregulated apoptosis playing a pivotal role. While NF-κB is a well-established mediator of cancer radioresistance (primarily through anti-apoptotic mechanisms), the paradoxical pro-apoptotic function of…