1.760 hasil
Menampilkan 1–20 · 0,12 detik · RSS
Molbank
Scopus
ISSN 1422-8599 · MDPI AG · 1.760 artikel di indeks
-
Artikel Jurnal Teks lengkap
8-Phenyl-13a-(trifluoromethyl)-13aH-benzo[4,5]imidazo[1,2-a]chromeno[3,2-e]pyridine-6-carbonitrile
A DABCO-catalyzed one-pot synthesis of a novel pentacyclic heterocycle featuring an unprecedented benzo[4,5]imidazo[1,2-a]chromeno[3,2-e]pyridine scaffold from 2-(cyanomethyl)benzimidazole and 3-trifluoroacetyl-4-phenyl-4H-chromene has been developed. This hybrid architecture merges three…
-
Artikel Jurnal Teks lengkap
(E)-Methyl 3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate
The synthesis of methyl (E)-3-(2-amino-4-chloro-6-morpholinopyrimidin-5-yl)acrylate 3 was accomplished using a Schlosser-modified Wittig reaction. Complete 1H and 13C NMR signal assignments confirm the formation of E-alkene.
-
Artikel Jurnal Teks lengkap
(5R,5aR,8aR,9S)-9-(2-Bromo-3,4,5-trimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3′,4′:6,7]naphtho[2,3-d][1,3]dioxol-5-yl 3,4,5-trimethoxybenzoate
In this report, we describe the synthesis and full spectroscopic characterization of a previously unreported podophyllotoxin (PTOX) analogue bearing a second 3,4,5-trimethoxyphenyl (TMP) unit at the C-4 position through an ester linkage. This dual-TMP PTOX derivative is obtained from a brominated…
-
Artikel Jurnal Teks lengkap
2-Iodopyridin-3-yl acetate
The title compound 2-iodopyridin-3-yl acetate was obtained by acetylation of the OH group of 2-iodo-3-hydroxypyridine. Knowing that the hydroxyl group, as a strong H-bond donor in halogenated hydroxypyridines, usually directs supramolecular packing and might enforce possible halogen–halogen…
-
Artikel Jurnal Teks lengkap
Diisopropyl(6-(phenyl(phenylthio)arsaneyl)-1,2-dihydroacenaphthylen-5-yl)phosphane
Peri-substituted bis(tertiary) phosphine-arsine Acenap(PiPr2)(As(SPh)Ph) (4, Acenap = acenaphthene-5,6-diyl) was synthesized by the reaction of the chloroarsine (PiPr2)(AsPhCl) with PhSLi. The X-ray crystal structure of this compound reveals an intramolecular P∙∙∙As–Cl pnictogen bond, with the…
-
Artikel Jurnal Teks lengkap
2,3,4,6-Tetra(9H-carbazol-9-yl)benzonitrile
Here, we synthesized 2,3,4,6-tetra(9H-carbazol-9-yl)benzonitrile (4CzHPN) via visible-light-driven photocatalytic monodecyanation using the versatile metal-free catalyst 4CzIPN. Characterized by NMR, IR, X-ray diffraction, and DFT calculations, it features a 3.49 eV HOMO-LUMO gap and shows…
-
Artikel Jurnal Teks lengkap
Crystal Structure of [1046127-79-0], 3,3′-(n-Hexane-1,6-diyl)bis(1-vinylimidazolium) Bromide
Vinylimidazolium salts constitute a highly relevant class of polymerizable heterocycles, especially in the field of so-called polymer ionic liquids (PILs), and they are frequently used as components of polyelectrolytes. Therefore, crystallographic characterizations, in particular studies of charge…
-
Artikel Jurnal Teks lengkap
(2R,3R,5R,6S)-5-Bromo-2-{[(2R,3R,5R)-3-bromo-5-(propa-1,2-dien-1-yl)tetrahydro-furan-2-yl]methyl}-6-ethyltetrahydro-2H-pyran-3-ol
As a part of an SAR study aimed at testing the antitumor activity of some C15 acetogenins related to mycalin A, we report here the synthesis of the C-1 debromo-derivative of laurenciallene, a substance recently isolated from the red alga Laurencia obtusa. This new substance has been obtained by the…
-
Artikel Jurnal Teks lengkap
2-(3′,5′-Bis((dodecyloxy)carbonyl)-2′,6′-dimethyl-1′,4′-dihydro-[3,4′-bipyridin]-1-ium-1-yl)-1,3-dioxo-2,3-dihydro-1H-inden-2-ide
Indane-1,3-dione and 1,4-dihydropyridine (1,4-DHP) scaffolds are of significant interest in medicinal chemistry. Herein, we report the synthesis characterization of a new lipid-like indane-1,3-dione–1,4-DHP betaine…
-
Artikel Jurnal Teks lengkap
(2RS,3aRS,9aRS)-3a-Methyl-2-phenyl-3,3a,9,9a-tetrahydro-1H-benzo[f]indol-4(2H)-one Hydrobromide
(2RS,3aRS,9aRS)-3a-methyl-2-phenyl-3,3a,9,9a-tetrahydro-1H-benzo[f]indol-4(2H)-one hydrobromide was first synthesized via a tandem aza-Cope rearrangement and Mannich reaction from (1RS,2SR)-2-amino-1-(prop-1-en-2-yl)-2,3-dihydro-1H-inden-1-ol, which, in turn, was obtained in four steps from…
-
Artikel Jurnal Teks lengkap
N-(4-Methoxyphenethyl)-2-propylpentanamide
Herein, we report the mechanochemical synthesis of a novel hybrid molecule, N-(4-methoxyphenethyl)-2-propylpentanamide. This solvent-minimized synthesis aligns with the principles of Green Chemistry and exemplifies the emerging paradigm of medicinal mechanochemistry, offering an efficient…
-
Artikel Jurnal Teks lengkap
Molecular Structure of the Monohydrate Hydrochloride Salt of the Antimalarial Drug Chloroquine
We report the crystallization and single-crystal X-ray analysis of the monohydrate hydrochloride salt of chloroquine(CQ), abbreviated CQHCl·H2O, an antimalarial drug with the formula C18H26ClN3. The crystal structure reveals a well-defined supramolecular architecture stabilized by an extensive…
-
Artikel Jurnal Teks lengkap
Synthesis and Characteristics of New 3-(Dichloromethyl)-2-nitro-6,7-dihydro-1-benzofuran-4(5H)-ones
The previously unknown compounds—3-(dichloromethyl)-2-nitro-6,7-dihydro-1-benzofuran-4(5H)-ones—have been synthesized and structurally characterized via single-crystal X-ray diffraction, 1H, 13C–{1H}, 1H–13C HMQC and 1H–13C HMBC NMR spectroscopy, IR, and UV spectroscopy.
-
Artikel Jurnal Teks lengkap
Structural and Electronic Insights into Arylalkanones from Myristica ceylanica
A phytochemical investigation of Myristica ceylanica resulted in the identification of seven arylalkanone-derived phenolic compounds, comprising one new naturally occurring arylalkanone (A), two derivatives (A1 and A2) prepared by chemical synthesis, and four known malabaricones (B–E). Density…
-
Artikel Jurnal Teks lengkap
2-((6,7-Dimethoxy-4-oxo-3-(4-(trifluoromethyl)phenethyl)-3,4-dihydroquinazolin-2-yl)thio)-N-(4-ethylphenyl)butanamide
2-({3-[2-(1-cyclohexen-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide (K284-6111; K284), the representative CHI3L1 inhibitor, has interesting biological activities, including anti-cancer and anti-inflammatory effects on neuroinflammation. Following…
-
Artikel Jurnal Teks lengkap
Synthesis of 1-(Naphthalen-2-yl)-3-(3-(triethoxysilyl)propyl)urea and Determination of Its Crystal Structure
The addition of 3-isocyanatopropyltriethoxysilane and 2-aminonaphthalene in THF affords the title compound 1-(naphthalen-2-yl)-3-(3-(triethoxysilyl)propyl)urea 1. A determination of the crystal structure of this naphthyl urea reveals the occurrence of strong intermolecular N-H···O hydrogen bonds…
-
Artikel Jurnal Teks lengkap
Ethyl 2-(2-((6-Methyl-4-oxo-4H-chromen-3-yl)methylene)hydrazineyl)thiazole-4-carboxylate
This study presents the synthesis of a new compound, ethyl 2-(2-((6-methyl-4-oxo-4H-chromen-3-yl)methylene)hydrazinyl)thiazole-4-carboxylate, obtained by the Hantzsch heterocyclisation reaction. The compound was analyzed through melting point determination, 1H and 13C NMR spectroscopy, infrared…
-
Artikel Jurnal Teks lengkap
Methyl 2-(Chloromethoxy-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-3-carboxylate
Overexpression of protein phosphatase 5 (PP5) is implicated in tumor cell growth, establishing PP5 as a compelling target for small-molecule anticancer therapy. Building on prior success in achieving selectivity within the PP2A domain through scaffold functionalization that maximizes active-site…
-
Artikel Jurnal Teks lengkap
Synthesis of 5′-Chlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazin)-3′-amine and 10-Chloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-dien-6-amine
Reactions of 3′,5′-dichlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazine) or 6,10-dichloro-1,4-dioxa-8-thia-7,9-diazaspiro[4.5]deca-6,9-diene with ammonia in MeCN, at ca. 20 °C, gave 5′-chlorospiro(benzo[d][1,3]dioxole-2,4′-[1,2,6]thiadiazin)-3′-amine and…
-
Artikel Jurnal Teks lengkap
Synthesis and Investigation of a Symmetrical Bis(methoxycarbonyl)-Substituted Rubrene Derivative
A symmetrical rubrene derivative, 5,6-bis(4-(methoxycarbonyl)phenyl)-11,12-diphenyltetracene, was synthesized via the thermal dimerization of 1,1-diphenyl-3-[4-(methoxycarbonyl)phenyl]-3-chloroallene. The reaction proceeded with the low selectivity typical of the classical “rubrenic synthesis”…
Menampilkan maksimal 50 halaman. Persempit pencarian dengan filter untuk hasil yang lebih spesifik.