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Journal of Biomedical Science
Scopus
ISSN 1423-0127 · BMC · 1.428 artikel di indeks
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Artikel Jurnal
Phage–antibiotic synergy restores β-lactam efficacy in MDR Klebsiella quasipneumoniae biofilms and suppresses resistance
Abstract Background Biofilms formed by multidrug-resistant (MDR) Klebsiella spp. present a significant clinical challenge due to elevated antibiotic tolerance. Bacteriophages (phages) represent a promising alternative, particularly in combination with antibiotics, where phage–antibiotic synergy…
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Artikel Jurnal
Mod-SE(2): a geometric deep learning framework for brain tumor classification and segmentation in MRI images
Abstract Background Accurate classification and segmentation of brain tumors in MRI scans are essential for diagnosis and treatment planning. However, the heterogeneous morphology of brain tumors, including irregular shapes, sizes, and spatial variability, makes this task highly challenging…
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Artikel Jurnal
Targeting mechanosensitive cannabinoid receptor 1 with isoflavone prodrugs attenuates atherosclerotic endothelial dysfunction
Abstract Background Despite therapeutic advances, atherosclerosis remains a major global health challenge. Most current treatments target systemic risk factors rather than the diseased vascular wall. Our previous work identified genistein, a soy isoflavone, as a cannabinoid receptor 1 (CB1)…
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Artikel Jurnal
Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity
Abstract Background Cancer cell plasticity enables dynamic transitions between cellular states, contributing to tumor progression and the acquisition of phenotypic traits such as vascular mimicry (VM), which promotes malignancy and resistance to anti-angiogenic therapies. Thrombomodulin (TM), a…
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Artikel Jurnal
Osmotin-derived 9-amino-acid peptide alleviates α-synuclein and MPTP-induced glial cell activation mediated neuroinflammation, protecting dopaminergic neurons in Parkinson’s disease mice brain
Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, categorized by the loss of dopaminergic neurons in the brain’s Substantia Nigra pars compacta (SNpc) due to α-synuclein (α-syn) aggregation, leading to reduced dopamine levels in the striatum. This…
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Artikel Jurnal
Microbiome modulation of tumorigenesis and immune responses
Abstract The microbiome has emerged as a critical, context-dependent regulator of tumorigenesis and anticancer immunity, capable of either promoting cancer progression or protecting against malignancy. This dual role is mediated by multiple interconnected mechanisms—including chronic inflammation…
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Artikel Jurnal
PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer
Abstract Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway (SSP), is a central metabolic hub and multifunctional oncoprotein that drives tumorigenesis through both canonical and non-canonical mechanisms. This review outlines the multi-level…
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Artikel Jurnal
Molecular insights into the antimicrobial and cardiometabolic functions of Lactobacillus crispatus isolated from the reproductive tract microbiota of Indian women
Abstract Background Lactobacillus crispatus is a dominant member of the healthy female reproductive tract microbiota, contributing to mucosal homeostasis and pathogen exclusion. Numerous studies have highlighted the protective effects of L. crispatus against both intestinal and genital infections…
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Artikel Jurnal
GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model
Abstract Background Recent research has revealed a strong connection between neuroinflammation and TAU protein-related neurodegeneration. A key discovery shows that the NLRP3 inflammasome, when activated, can significantly impact TAU pathology and subsequent neuronal death. This process involves…
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Artikel Jurnal
Tumor-on-chip’s alliance with molecular pathology against metastatic disease
Abstract Background Cancer is the second leading cause of death worldwide. While significant progress has been made in early detection and treatment, metastasis remains the major cause of cancer-related morbidity and mortality. In the last decade the rate of long-term survivorship of metastatic…
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Artikel Jurnal
CCL5/RANTES signaling in inflammation dysregulation after mild traumatic brain injury
Abstract Background Mild traumatic brain injury (mTBI) is the most prevalent form of brain injury. Secondary damage following mTBI contributes to neuronal degeneration by promoting neuroinflammation, amyloid accumulation, and oxidative stress (OS). Microglia exhibit dual roles after injury…
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Artikel Jurnal
PROTAC-based protein degradation: a window of opportunity for melanoma therapy
Abstract The key small molecule-based modalities for inducing targeted protein degradation have seen explosive growth over the past decade. They include heterobifunctional degraders such as PROteolysis TArgeting Chimeras (PROTACs): molecules working as protein degraders by inducing proximity…
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Artikel Jurnal
TRKB-based signature identifies high-risk squamous cell carcinoma cases and TRKB blockade reprograms tumor and stromal cells toward suppressive phenotypes
Abstract Background Cutaneous squamous cell carcinoma (cSCC) is a common age-related cancer, with a subset prone to recurrence and metastasis. Currently, no useful diagnostic biomarkers for high-risk cSCC are available. Based on our previous findings, indicating that age-related changes in the…
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Artikel Jurnal
TGF-β signaling mediates crosstalk between CD8+ T cells and CD39+ induced Treg cells in autoimmune inflammation
Abstract Background Autoimmune inflammation results from dysregulated immune responses, with dysfunction of regulatory T cells (Tregs) being a key contributor due to their critical role in maintaining immune tolerance. The stability and function of Tregs are strongly influenced by the inflammatory…
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Artikel Jurnal
Mass spectrometry-based human spatial omics: fundamentals, innovations, and applications
Abstract Mass spectrometry-based spatial omics is a powerful approach for visualizing the spatial organization of proteins, metabolites, lipids, and other biomolecules in situ, combining the molecular depth of mass spectrometry with spatially resolved imaging. This systematic review traces the…
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Artikel Jurnal
APP-C31 pathology as a target in neurodegenerative diseases
Abstract Neurodegenerative diseases (Alzheimer’s disease, Parkinson's disease, Huntington’s disease, etc.) are caused by the progressive loss of neurons, which affects many people worldwide. Therefore, many efforts have focused on neurodegenerative disease mechanisms and therapeutic strategies…
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Artikel Jurnal
Hilar mossy cell oxytocin receptor signaling regulates adult hippocampal neurogenesis and context discrimination in mice
Abstract Background Neurogenesis is a crucial form of neuroplasticity in the adult mammalian brain. Hilar mossy cells (MCs) in the dentate gyrus show a uniquely high expression of oxytocin receptors (OXTRs) and are implicated in the regulation of adult hippocampal neurogenesis (AHN). However, it…
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Artikel Jurnal
Intestinal epithelial Smad7 drives purine metabolic dysregulation and ileal inflammation
Abstract Background and aims Defects of the gut epithelial barrier and counter-regulatory mechanisms are a prerequisite for the onset of intestinal inflammation in patients with inflammatory bowel diseases (IBD). Elevated levels of Smad7, an inhibitor of TGF-β1, in both epithelial and immune cells…
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Artikel Jurnal
Genetic variation and mutational determinants of azole resistance in Candida albicans strains of oropharyngeal colonization in HIV patients and bloodstream infections
Abstract Objectives We aimed to analyze the genomic variations associated with high azole resistance in the C. albicans isolates of intensive care unit (ICU) patients with Candida bloodstream infections (BSIs) and those from oropharyngeal colonization in HIV patients. Methods The genomic DNA of…
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Artikel Jurnal
miR-196a reduces mutant Huntingtin aggregates by Rad23b-mediated degradation in Huntington’s disease
Abstract Background Huntington’s disease (HD) is a neurodegenerative disorder caused by abnormal expansions of poly-glutamine repeats in the mutant Huntingtin (mHTT). The expanded proteins form pathological aggregates to disrupt neuronal functions during disease progression, suggesting the…
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