863 hasil
Menampilkan 1–20 · 0,25 detik · RSS
Tumor Biology
Scopus
ISSN 1423-0380 · SAGE Publishing · 863 artikel di indeks
-
Artikel Jurnal
Beyond proficiency testing: Leveraging commutable External Quality Assessment data to harmonize tumor markers and refine medical decision points
Background Serum tumor markers such as carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and prostate-specific antigen (PSA) are crucial to clinical decision-making based on defined medical thresholds. However, significant inter-method variability and lack of harmonization limit result…
-
Artikel Jurnal
Digitoxin as a novel synergistic partner of cisplatin in triple-negative breast cancer (TNBC) cells
Background Triple-negative breast cancer (TNBC) remains clinically challenging due to its aggressive nature, high recurrence rate, and lack of targeted therapies. To address these limitations, combination chemotherapies that synergistically enhance antitumor efficacy while permitting dose reduction…
-
Artikel Jurnal
Standardization of prostate-specific antigen assays: Impact on reference intervals and clinical decision thresholds
Background Prostate-specific antigen (PSA) remains the most widely used biomarker for prostate cancer screening, diagnosis, and monitoring. However, despite decades of standardization efforts, significant inter-assay variability persists, with important consequences for clinical interpretation and…
-
Artikel Jurnal
Tumour markers and evidence-based pathology
Background Tumour biomarkers have become increasingly important in oncology, shaping cancer diagnostics, classification, and patient management. Despite their potential, the use of cancer biomarkers in clinical settings remains limited. Objective This paper aims to outline biomarker development…
-
Artikel Jurnal
Osteopontin-c gene expression and subcellular localization in ovarian cancer cells: Implications for prognosis and therapeutic responses
Background Osteopontin is a glycophosphoprotein aberrantly expressed in several tumor types, which exhibits several isoforms generated by post-translational and post-transcriptional mechanisms, including alternative splicing. Among total osteopontin (tOPN), the osteopontin-c (OPN-c) splice variant…
-
Artikel Jurnal
Asporin increases the extracellular matrix cross-links and inhibits the cancer cell migration
Background Migrating strategies of the triple-negative breast cancer (TNBC) together with its role in the establishment of tumor microenvironment (TME), supporting metastasis, have been extensively studied. Extracellular matrix (ECM) is a major player for the TME, establishing the 3D spatial…
-
Artikel Jurnal
External validation of a serum tumor marker algorithm for early prediction of no durable benefit to immunotherapy in metastastic non-small cell lung carcinoma
Background Immune checkpoint inhibitors (ICIs) provide a significant survival benefit in non-small cell lung cancer (NSCLC) patients; however, accurately predicting which patients will benefit remains a challenge. As previously shown, the STOP model, a machine learning model based on serum tumor…
-
Artikel Jurnal
An integrated bioinformatics and multi-omics investigation of the sirtuin family to identify their prognostic importance in human cancers
Background In recent years, the significance of sirtuins in cancer biology has become increasingly evident, but their molecular mechanisms and prognostic impacts remain elusive. Objective The present study aimed to investigate the differential expression of the sirtuin gene family across cancers…
-
Artikel Jurnal
Evaluation of cytotoxic and anticancer effect of methanolic extract on cancer cell lines
We aimed to assess the antitumor activity of Orobanche crenata methanolic extract and evaluate its cytotoxic effect on different cancer cell lines to develop an effective natural anticancer drug. Components of O. crenata methanolic extract were analyzed using gas chromatography–mass spectrometry…
-
Artikel Jurnal
Evaluating macrophage migration inhibitory factor 1 expression as a prognostic biomarker in colon cancer
Objective: Several studies indicate that macrophage migration inhibitory factor 1 plays a role for tumor progression in colon cancer. We investigated whether determination of migration inhibitory factor 1 mRNA expression levels in lymph nodes of colon cancer patients could be used as a prognostic…
-
Artikel Jurnal
Overexpression of associated with altered genome and poor survival in selected types of human cancer
Base excision repair, which is initiated by the DNA N -glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. Several base excision repair genes are deregulated in cancer and affect cellular outcomes to chemotherapy and carcinogenesis. Endonuclease VIII-like 3…
-
Artikel Jurnal
Increased circulating tumor DNA as a noninvasive biomarker of early treatment response in patients with metastatic ovarian carcinoma: A pilot study
Detection of circulating tumor DNA is a new noninvasive technique with potential roles in diagnostic, follow-up, and prognostic evaluation of patients with many types of solid tumors. We aimed to evaluate the role of circulating tumor DNA in the setting of metastatic ovarian carcinoma. A…
-
Artikel Jurnal
Samarium enriches antitumor activity of ZnO nanoparticles via downregulation of CXCR4 receptor and cytochrome P450
Cancer is the leading cause of death and exhausts human and economic resources for treatment and protection. Zinc oxide nanoparticles play an effective role in tumor treatment but with some cautions, such as overexpression of cytochrome P450, hepatic overload, and the mammalian target of rapamycin…
-
Artikel Jurnal
The emerging role of targeting cancer metabolism for cancer therapy
Glucose, as the main consuming nutrient of the body, faces different destinies in cancer cells. Glycolysis, oxidative phosphorylation, and pentose phosphate pathways produce different glucose-derived metabolites and thus affect cells’ bioenergetics differently. Tumor cells’ dependency to aerobic…