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Annals of Hematology
Scopus
ISSN 1432-0584 · Springer · 503 artikel di indeks
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Artikel Jurnal
Age and gender effects on molecular responses in chronic myeloid leukemia patients by first-line treatment: an Italian CML network cohort study
Abstract Among prognostic factors influencing the achievement of molecular responses in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs), age has been suggested with contrasting results, while the role of gender is still uncertain. A large cohort of 1,394 newly…
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Real-world outcomes of ponatinib in heavily pretreated patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia
Abstract To evaluate the real-world efficacy and safety of ponatinib, we conducted a multicenter, prospective post-marketing surveillance study in patients with chronic phase (CP), accelerated phase (AP), or blast phase (BP) chronic myeloid leukemia (CML) or Philadelphia chromosome–positive acute…
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Guided by target selection, inotuzumab ozogamicin successfully salvaged a patient with refractory follicular lymphoma after anti-CD19 and anti-CD22 CAR T-cell therapy: a case report and literature review
Abstract Although Chimeric antigen receptor (CAR) T-cell therapy has achieved a high response rate in recurrent/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL), the prognosis of the patients who do not respond to this therapy or have a disease progression again is poor. A 69-year-old male…
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Artikel Jurnal
Real-world outcomes of SLiM-only multiple myeloma: Korean Multicenter Retrospective analysis (KMM2401 study)
Abstract In the 2014 update, SLiM biomarkers were included into the "myeloma defining events" as these markers were shown to be significantly associated with early progression to active multiple myeloma (MM). However, several subsequent studies have reported more favorable outcomes. To further…
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Artikel Jurnal
Platelet-neutrophil ratio as a potential biomarker for stroke risk stratification in children and young adults with sickle cell anaemia in resource poor settings
Abstract Sickle cell anaemia (SCA) is associated with a significantly increased risk of stroke, primarily assessed using transcranial Doppler ultrasound (TCD). However, access to TCD and haemoglobin F (HbF) testing remains limited in resource-constrained settings. Our preliminary findings…
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Efficacy and safety of belumosudil for refractory chronic graft-versus-host disease in routine practice
Abstract Chronic graft versus host disease (cGVHD) affects 30–50% of allogeneic hematopoietic stem cell transplantation recipients, with those failing standard therapy including ruxolitinib constituting an important unmet medical need. We retrospectively analyzed the use of the ROCK2 inhibitor…
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Artikel Jurnal
Epiregulin levels and their association with prognostic factors in Hodgkin lymphoma: a case-control study
Abstract Epiregulin, a polypeptide involved in inflammation, cell proliferation, tumor development, and tissue remodeling pathophysiology, plays a crucial role in the etiopathogenesis of malignancies. This prospective case-control study aimed to investigate the association between epiregulin levels…
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Daratumumab-based first-line therapy benefit multiple myeloma patients in a real-world setting: a multi-center retrospective propensity score-match study
Abstract Background: Adding daratumumab to initial therapy in randomized controlled trials (RCTs) for newly diagnosed multiple myeloma (MM) enhances deep remission and prolongs progression-free survival (PFS). Given the differences between trial-eligible and real-world patients, and healthcare…
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The impact of the expression signatures of LncRNAs HBBP1 and XIST on the diagnostic significance of patients with β-Thalassemia
Abstract β-thalassemia is an inherited blood disorder with long-term associated complications. The purpose of this study was to evaluate the clinical significance of the lncRNA-HBBP1 and lncRNA-XIST expression profiles in the diagnosis of β-thalassemia patients. One hundred children patients with…
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Artikel Jurnal
Neurofibromatosis type I -related severe aplastic anemia: an unusual association with a complicated bone marrow transplantation course
Abstract Severe aplastic anemia (SAA) is a life-threatening condition characterized by bone marrow failure, requiring immunosuppressive therapy or hematopoietic stem cell transplantation (HSCT). Neurofibromatosis type I (NF1) is an autosomal dominant disorder with diverse systemic manifestations…
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Maladaptive somatic gene rescue as predisposition to JAK2 molecular abnormalities? Insights from an Israeli family
Abstract Eosinophilia associated with PCM1::JAK2 fusion and classic Philadelphia (Ph)-negative myeloproliferative neoplasms (MPN) are both clonal disorders caused by a dysregulation of the JAK2 signaling pathway. The myeloid neoplasm with t(8;9)(p22;p24.1) and PCM1::JAK2 rearrangement is now…
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Factors contributing to the development of hemophilic arthropathy: A real-world study
Abstract Hemophilia A is a rare X-linked bleeding disorder that often leads to hemophilic arthropathy (HA), a major cause of disability and an important healthcare burden worldwide. To identify the factors associated with HA among Colombian patients with severe hemophilia A and to evaluate how…
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Artikel Jurnal
Long-term real-world thrombotic and clinical outcomes in polycythemia vera – a hospital-based i2b2 cohort study
Abstract Though the thrombotic risk in polycythemia vera (PV) is well known, long-term real-world data remain limited. This retrospective study at Bern University Hospital aimed to evaluate complications in PV patients, focusing on thrombotic events, associated risk factors, and disease outcomes…
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Comprehensive geriatric assessment (CGA) scale does not effectively identify elderly AML patients suitable for intensive induction chemotherapy – a multicenter study from Polish Adult Leukemia Group
Abstract Standard scales, such as ECOG Performance Status, Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI), and Activities of Daily Living (ADL), are commonly used to stratify patients with acute myeloid leukemia (AML) for intensive chemotherapy (IC). Comprehensive geriatric…
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Artikel Jurnal
Burixafor, a CXCR4 inhibitor with a differentiated kinetics profile: results of a phase 2 study for rapid cell mobilization in multiple myeloma and lymphoma patients undergoing transplant
Abstract Inhibitors of C-X-C chemokine receptor type 4 (CXCR4) are standard of care for mobilization of hematopoietic stem and progenitor cells (HPC) in transplant eligible patients with hematological malignancies or undergoing HPC-based gene therapies. Burixafor hydrobromide is a potent and…
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Artikel Jurnal
Efficacy and safety of epcoritamab in relapsed or refractory large B-cell lymphoma: 3-year update from the EPCORE NHL-1 trial
Abstract Epcoritamab, a CD3xCD20 bispecific antibody, resulted in deep, durable responses with a manageable safety profile in patients with relapsed/refractory large B-cell lymphoma (LBCL) in EPCORE® NHL-1 (NCT03625037). We report results from a 3-year follow-up. Adults with relapsed/refractory…