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Journal of Cancer Research and Clinical Oncology
Scopus
ISSN 1432-1335 · Springer · 544 artikel di indeks
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Artikel Jurnal
Treatment of retroperitoneal sarcoma in Germany between 2000 and 2022: a retrospective analysis from the German Cancer Registry Group
Abstract Purpose This study describes the treatment of retroperitoneal sarcoma (RPS) in Germany between 2000 and 2022, comparing it to existing recommendations and guidelines. Methods Data from the cancer registries of 13 out of 15 federal states was used. Included cases had a retroperitoneal…
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Artikel Jurnal
A single-cell derived spheroid approach to dissect intratumoural heterogeneity in colorectal cancer: cell lines show changes in proteomes and therapeutic response to 5-FU
Abstract Purpose Colorectal cancer (CRC) stands as a significant contributor to cancer-related mortality. Owing to its prognostic and therapeutic implications, intratumoural heterogeneity (ITH) presents a considerable challenge. We have developed an experimental framework integrating single-cell…
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Artikel Jurnal
Patient-reported outcomes regarding the use of complementary and alternative medicine (CAM) in BCR::ABL1-negative myeloproliferative neoplasias
Abstract Introduction BCR::ABL1-negative myeloproliferative neoplasms are chronic diseases characterized by high symptom burden due to systemic inflammation. Treatment objectives include cytoreduction and alleviation of symptoms. Besides standard therapies, complementary and alternative medicine…
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Artikel Jurnal
The GC-derived exosomal LncRNA DARS-AS1 activates Wnt/β-catenin pathway to drive angiogenesis by regulating miR-605-5p/BCL9
Abstract Background Gastric cancer (GC) is one of the most prevalent and aggressive malignancies globally, characterized by high morbidity and mortality rates despite advancements in medical technologies and screening methods. Recent studies have suggested that long non-coding RNAs (lncRNAs)…
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Artikel Jurnal
When AI joins the table: evaluating large language model performance in soft tissue sarcoma tumor board decisions
Abstract Objectives Multidisciplinary tumor boards (MDTs) are critical for the personalized management of soft tissue sarcomas (STS), but they are limited by time, costs, and resource demands. With recent advances in large language models (LLMs) like ChatGPT, there is growing interest in evaluating…
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Artikel Jurnal
Personalizing cancer risk: a systematic review of risk communication strategies
Abstract Purpose: Personalized risk communication (PRCom) can help individuals make informed decisions about electing to undergo cancer screening based on their specific risk. In this systematic review, we examined existing risk communication strategies used in the presentation of PRCom and how…
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Artikel Jurnal
Crosstalk between mitophagy and breast cancer: mechanisms of action and clinical applications
Abstract Mitophagy, a key mechanism of selective autophagy, maintains cellular homeostasis by removing dysfunctional mitochondria, and its dysregulation is closely associated with tumor initiation and progression. As breast cancer remains one of the most prevalent malignancies among women…
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Artikel Jurnal
Racial/ethnic and sex disparities in mortality among US cancer survivors
Abstract Backgrond Cancer survivors in the United States face significant disparities in mortality influenced by race and sex. Despite advances in cancer treatment, the disparities of social determinants, behavioral health, and metabolic risk factors remain underexplored. Methods Analysis was based…
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Artikel Jurnal
Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment
Abstract Purpose Glioblastoma, IDH-wildtype is a highly aggressive and often recurrent brain malignancy characterized by a profoundly immunosuppressive and heterogeneous tumor microenvironment. In this study, we aimed to systematically compare commonly used immune profiling methodologies. Methods…
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Artikel Jurnal
Hormonal management after risk-reducing surgery in BRCA-mutated triple-negative breast cancer survivors
Abstract Premenopausal women carrying a BRCA1 or BRCA2 mutation are frequently advised to undergo risk-reducing bilateral salpingo-oophorectomy (BSO) to lower their significantly increased lifetime risk of ovarian cancer. However, this procedure induces abrupt estrogen deprivation, resulting in…
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Artikel Jurnal
Real-world monitoring strategies and predictors guiding the transition from active surveillance to treatment in ISUP 1 prostate cancer
Abstract Purpose Active surveillance (AS) is the standard approach for managing ISUP 1 prostate cancer (PCa), ensuring oncological safety while minimizing overtreatment. However, AS protocols vary significantly. This study assessed a structured AS protocol incorporating PSA kinetics…
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Artikel Jurnal
RBM15B promotes hepatocellular carcinoma progression via IGF2BP1-mediated ITSN2 mRNA stabilization
Abstract Background N6-methyladenosine (m6A) is a chemical modification of adenosine in RNA that plays a crucial role in the regulation of gene expression. As the most abundant form of RNA chemical methylation, m6A is aberrantly expressed in hepatocellular carcinoma (HCC), where it affects multiple…
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Artikel Jurnal
Modified clear cell likelihood score and a new CAT score in the assessment of indeterminate small renal masses
Abstract Purpose In recent decades, small renal masses (SRMs) have become common incidental findings in cross-sectional studies; however, a widely implemented approach for the characterization of SRMs is still lacking. Thus, in this study, we aimed to explore the diagnostic performance of existing…
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Artikel Jurnal
From mechanism to clinic: a panoramic perspective on targeting HMOX1 to overcome drug resistance
Abstract Drug resistance is a pivotal factor leading to the failure of cancer therapy, within which heme oxygenase-1 (HMOX1) plays a complex and paradoxical dual role. On one hand, HMOX1 protects cancer cells from oxidative damage induced by chemotherapeutic drugs through its antioxidant…
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Artikel Jurnal
Targeting SLC6A8 suppresses tumor growth and enhances ferroptosis in hepatocellular carcinoma
Abstract Background Hepatocellular carcinoma (HCC) persists as a therapeutic challenge owing to restricted treatment alternatives and the dearth of effective biomarkers. The creatine transporter SLC6A8 has been documented to participate in the progression of various malignancies. However, the role…
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Artikel Jurnal
Single-cell hdWGCNA identifies checkpoint inhibitor pneumonitis-linked CD4 + T-cell subsets driving immunotherapy response and prognosis in lung cancer
Abstract Background Immune checkpoint inhibitors (ICIs) have achieved promising efficacy in lung cancer patients, yet checkpoint inhibitor-related pneumonitis (CIP) remains a severe and incompletely understood complication. The pathogenesis of CIP and its impact on immunotherapy outcomes remain…
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Artikel Jurnal
GALNT5 drives colorectal cancer progression and chemoresistance via PI3K/Akt/ABCC1 axis
Abstract Background Polypeptide N-acetylgalactosaminyltransferase 5 (GALNT5), a member of the GALNT enzyme family, has been implicated in the pathogenesis of various malignancies. However, its precise role in colorectal cancer (CRC) progression and its contribution to acquired resistance to the…
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Artikel Jurnal
Comment on “Theranostic lipid nanocarriers for precision diagnosis and targeted therapy in pancreatic ductal adenocarcinoma”
Abstract This letter comments on a recent review of theranostic lipid nanocarriers for pancreatic ductal adenocarcinoma, identifying three areas of concern in the evidence base. First, the 211-item reference list contains multiple duplicated citations listed under separate numbers with identical…