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Reproductive Medicine and Biology
Scopus
ISSN 1447-0578 · Wiley · 491 artikel di indeks
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Artikel Jurnal
Chitosan/Alginate‐Loaded Astragalus hamosus Shows Ameliorative Effects on Lipid Profile, Inflammatory and Hormonal Parameters, and Reduces miRNA‐222 Expression in Polycystic Ovary Syndrome Rats
ABSTRACT Purpose This study investigated the therapeutic effects of Chitosan/Alginate‐loaded Astragalus hamosus extract (Chn/Al‐AH) on the expression of miRNA‐222 and ESR1 genes, inflammatory cytokines, lipid profile, and reproductive hormones in a rat model of polycystic ovary syndrome (PCOS)…
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Artikel Jurnal
The physiological role of macrophages in reproductive organs
Abstract Background Macrophages are essential immune cells critical to reproductive physiology. They regulate key processes such as follicular development, ovulation, and luteinization in the ovaries. Macrophages are also involved in endometrial remodeling, immune tolerance, and placentation in the…
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Artikel Jurnal
Significance of Mitochondrial Dynamics in Reproductive Physiology: Current and Emerging Horizons in Mitochondrial Therapy for Assisted Reproductive Technologies
ABSTRACT Background Mitochondria play a critical role in cellular bioenergetics and signaling, with particular importance in the context of reproductive biology. This review summarizes their role in reproduction and explores current and emerging mitochondrial therapies for fertility treatment…
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Artikel Jurnal
The Genetic Landscape of Müllerian Duct Anomalies: A Comprehensive Review
ABSTRACT Background Müllerian duct anomalies (MDAs) are developmental malformations of the female genital tract that present as a series of abnormalities within the reproductive tracts of females. The etiology of MDAs is complex and heterogeneous, especially genetic factors. Methods We conducted a…
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Artikel Jurnal
Combined targeting of TCF7L1/2, PTEN, CDK6, and BCCIP by microRNA miR‐29c‐3p is associated with reduced invasion and proliferation of endometriotic cells
Abstract Purpose Endometriosis is a chronic gynecological disorder associated with pain symptoms and infertility. The expression of microRNA miR‐29c‐3p is dysregulated in endometriosis. We aimed to identify novel molecular targets of miR‐29c‐3p functionally linked to proliferation and invasive…
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Artikel Jurnal
KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice
ABSTRACT Purpose Kinesin Family Member 2C (KIF2C) is a key regulator of microtubule dynamics and chromosome segregation in mitosis. However, its role in spermatogenesis remains unclear. Recent transcriptomic analyses suggest a potential link between KIF2C and male infertility. This study aimed to…
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Possible mechanisms of spermatogenic dysfunction induced by viral infections: Insights from COVID‐19
Abstract Background As the COVID‐19 pandemic nears resolution in 2024, the mechanisms by which SARS‐CoV‐2 and other viral infections induce spermatogenic dysfunction remain poorly understood. This review examines the mechanisms by which viral infections, particularly COVID‐19, disrupt…
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Artikel Jurnal
C‐type natriuretic peptide promotes human granulosa cell growth and estradiol production: Implications for early follicle development
Abstract Purpose To investigate the effects of C‐type natriuretic peptide (CNP) on human granulosa cell growth and elucidate its regulatory mechanisms. Methods A human non‐luteinizing granulosa cell line (HGrC) developed from small antral follicles was used to assess the impact of CNP on cell…
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Artikel Jurnal
Polycystic ovary syndrome: Criteria, phenotypes, race and ethnicity
Abstract Background Polycystic ovary syndrome (PCOS) is a complex endocrinopathy, which leads to ovulation dysfunction and infertility, as well as metabolic and mental disorders. Women with PCOS exhibit several characteristic symptoms, with marked heterogeneity across different races and…
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Artikel Jurnal
Melatonin improves the in vitro growth of bovine oocytes collected from early antral follicles by maintaining oocyte‐cumulus cell communication
Abstract Purpose In vitro, oocyte development is susceptible to oxidative stress, which leads to endoplasmic reticulum (ER) stress. This study investigated whether the antioxidant melatonin attenuates ER stress and maintains oocyte‐cumulus cell communication during the in vitro growth (IVG) of…
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Short‐Term Exposure to Culture Media Used in Human ART Shapes Early Calcium Oscillations in ICSI‐Fertilized Mouse Oocytes and Impacts Adult Phenotype
ABSTRACT Purpose The influence of culture media used during in vitro fertilization (IVF) on offspring phenotype remains controversial. However, specific effects of short exposure time after fertilization remain underexplored. By evaluating Ca2+ oscillations as a readout of the first response of…
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Comparative prospective study on the clinical utility of G‐banding and next‐generation sequencing for chromosomal analysis of products of conception under Advanced Medical Care A in Japan
Abstract Purpose To compare the clinical utility of G‐banding and next‐generation sequencing (NGS) for chromosomal analysis of products of conception (POC), a crucial tool for detecting fetal chromosomal abnormalities which are major causes of miscarriage and stillbirth. Methods We evaluated the…
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Influence of Medical Versus Surgical Evacuation of Early Miscarriage Loss on Reproductive Outcomes of Women in Subsequent FET Cycle
ABSTRACT Purpose To investigate how two methods for managing early miscarriage after frozen embryo transfer (FET) cycles impact live birth rates and other reproductive and perinatal outcomes in subsequent FET cycles without preimplantation genetic testing for aneuploidy (PGT‐A). Methods This…
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Artikel Jurnal
The effect of ionizing radiation on testicular interstitial stromal cells
Abstract Purpose Testis is one of the most radiosensitive tissues. Interstitial stromal cells play a supportive role in male fertility, but radiation‐induced damage to those cells has not yet been well understood. We aimed to investigate radiation‐induced changes in interstitial stromal cells in…
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Artikel Jurnal
A machine learning model for predicting fertilization following short‐term insemination using embryo images
Abstract Purpose This study established a machine learning model (MLM) trained on embryo images to predict fertilization following short‐term insemination for early rescue ICSI and compared its predictive performance with the embryologist's manual classification. Methods Embryo images at 4.5 and 8…
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Artikel Jurnal
Combined Multiomics Analysis Reveals the Role of ANXA1 Methylation and miRNA‐Targeted LDLR in Polycystic Ovary Syndrome
ABSTRACT Purpose Polycystic ovary syndrome (PCOS) is an endocrine syndrome that afflicts women of childbearing age, whose specific pathogenesis is unknown. Combined multiomics analysis on it is still lacking. The purpose of this study was to use combined multiomics analyses to learn about the…
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Artikel Jurnal
Serum Lipids Maintain Granulosa Cell Membrane Structure in Antral Follicles During Warming/Thawing of Vitrified Mice Ovaries
ABSTRACT Purpose We demonstrated that briefly treating ovaries with collagenase before exposure to a hyperosmotic solution preserved secondary follicles. However, preserving antral follicles remained difficult. We investigated whether the absence of lipids in warming (thawing) solution is a…
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Artikel Jurnal
Molecular and cellular regulators of embryo implantation and their application in improving the implantation potential of IVF‐derived blastocysts
Abstract Background In vitro fertilization (IVF) and embryo transfer (ET) are widely used in reproductive biology. Despite the transfer of high‐quality blastocysts, the implantation rate of IVF‐derived blastocysts remains low after ET. Methods This article provides a comprehensive review of current…
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Artikel Jurnal
Ovarian Function Restoration Using Autologous Platelet‐Rich Plasma
ABSTRACT Background With the trend of delayed childbearing, the incidence of poor ovarian response (POR) with diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI) has increased. Effective treatments for ovarian function restoration are limited. Platelet‐rich plasma (PRP), an…