121 results
Showing 1–20 · 0.65 seconds · RSS
Expert Reviews in Molecular Medicine
Scopus
ISSN 1462-3994 · Cambridge University Press · 121 articles in the index
-
Journal Article Full text
Unravelling the Link between Polyphenol Intake and the Risk of Digestive System Cancer: An Umbrella Review Using Meta-Analyses and Systematic Reviews
Abstract Background Digestive system cancers (DSCs) constitute a significant number of cancer cases and are closely associated with modifiable risk factors. Objective This umbrella review synthesizes evidence from meta-analyses on the association between dietary polyphenol consumption and the risk…
Also available at: DOAJ
-
Journal Article
Alternative in vitro and in silico models to reduce animal use: a crucial technological advance in dermatological sciences
Abstract Introduction Alternative models are tools to replace and reduce the number of animals used in biomedical sciences, for either research or tests of industrial products. Several new alternative models have been developed in the most diverse fields. Their implementation has led to significant…
-
Journal Article
α-Synuclein in Lewy Body Diseases: Progress, Remaining Challenges and Future Perspectives
Lewy bodies (LBs) are the main pathological feature of the neurodegenerative diseases Parkinson’s disease and Dementia with LBs. Since their discovery over 100 years ago, it is only in the last three decades, that, a wealth of genetic, pathological and pre-clinical evidence puts the spotlight on…
-
Journal Article
Targeting CD39 as a Therapeutic for Cancer Immunotherapy
CD39 plays a pivotal role in the ATP-to-adenosine signalling pathway, serving as a critical mediator of immune suppression within the tumour microenvironment. Increasing preclinical evidence indicates that its inhibition can restore antitumour immunity and improve the efficacy of established…
-
Journal Article
Current in vitro Myocardial Infarction Co-Culture Models and their Verification for Clinical Relevance
Abstract Background Myocardial infarction (MI) remains a critical focus in cardiovascular research, with in vitro models serving as essential tools for investigating pathophysiological mechanisms and evaluating therapeutic strategies. Despite their widespread use, the clinical relevance of these…
-
Journal Article
Spinal muscular atrophy as a blueprint for precision therapy in neuromuscular disease
Abstract Background Spinal Muscular Atrophy (SMA) is caused by a deficiency of the survival motor neuron (SMN) protein due to loss of SMN1 and inefficient compensation by SMN2. This genetic architecture has driven the development of precision therapeutics. Over the past decade, SMA management has…
-
Journal Article
Multi-Omics in Kidney Disease Research: Technological Advances, Biomarker Discovery and Clinical Translation
Abstract Background Multi-omics research is reshaping precision nephrology by linking genetic susceptibility, epigenetic regulation, transcriptional state, protein abundance, metabolic activity and spatial tissue context within integrated analytical frameworks. Methods We critically reviewed recent…
-
Journal Article
Prospects and challenges of salivary gland tissue engineering in Sjögren’s syndrome
Sjögren’s syndrome (SS) is characterised by an autoimmune response that targets the salivary and lacrimal glands, resulting in dry mouth and eyes. In addition to these local manifestations, the systemic involvement of other organs can also occur. Current treatment options primarily focus on…
-
Journal Article
Lipidomic perspectives on the role of lactosylceramides in inflammation and disease: A narrative review
Abstract Background Lactosylceramides (LacCers) are glycosphingolipids that play essential roles in physiological and pathological processes across immune, endocrine, and neurological systems, with mechanistic studies demonstrating that LacCers modulate inflammatory signalling, oxidative stress…
-
Journal Article
Targeting JAK/STAT signalling with cold atmospheric plasma: a potential therapy for systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous multi-organ manifestations and poorly understood pathogenesis. The variable therapeutic outcomes and potential for cross-indication treatments underscore the need to identify pivotal disease-driving signalling…
-
Journal Article
Modulation of Female Reproductive Functions through Nerve Growth Factor: A Systematic Review
Abstract Background Nerve growth factor (NGF), which acts on receptors tropomyosin receptor kinase A and p75 neurotrophic receptor, is a member of neurotrophin family and a kind of secretory polypeptides. Methods A comprehensive literature search was conducted in the following databases: PubMed and…
-
Journal Article
The Tumor–Platelet–Immune Interface: Driving Metastasis, Pre-Metastatic Niche Formation and Therapeutic Vulnerabilities
Metastatic dissemination remains the leading cause of cancer-related mortality, driven not only by tumor-intrinsic factors but also by dynamic interactions within the tumor microenvironment (TME). Platelets and leukocytes orchestrate a systemic pro-metastatic network by shielding circulating tumor…
-
Journal Article
The Role that Biobanks Can Play in Driving Animal-Free Biomedical Research
Abstract Background In 2025, transformative and transnational plans to phase out animal testing and reduce reliance on animal use in research settings were introduced. Methods Steps towards realising these plans can be addressed by using human tissues and metadata obtained from biobanks. Biobanks…
-
Journal Article
The Effect of Acupuncture in Women with Polycystic Ovary Syndrome Undergoing in vitro Fertilization: A Systematic Review and Meta-Analysis
Abstract Background Acupuncture is increasingly used during in vitro fertilization and embryo transfer (IVF-ET), but its therapeutic benefits for women with polycystic ovary syndrome (PCOS) remain uncertain. Methods Eight databases were investigated from the inception until April 1, 2024. We…
-
Journal Article
A Comprehensive Evaluation of CAR-T Cell Gene Therapy, Tracing its Revolutionary Clinical Breakthroughs and Advancements Towards Next-Generation Engineering
Abstract Background CAR-T cell gene therapy has advanced from an experimental concept to a standard curative treatment for selected hematologic malignancies. Substantial clinical evidence has established CAR-T therapy as a cornerstone for relapsed/refractory B-cell malignancies and multiple…
-
Journal Article
Developing Galectin-3-Targeted Therapeutics in Diseases: Three Distinct Galectin-3 Segments for Targeting
The β-galactoside-binding protein galectin-3 is currently a hotly pursued therapeutic target in cancer, inflammation and fibrosis-associated diseases due to its multi-mode actions and broad impact on the pathogenesis and progress of the diseases. Various natures of galectin-3 inhibitors have been…
-
Journal Article
The Sphingolipid Rheostat in Female Reproductive Pathologies: From Molecular Mechanisms to Precision Therapeutics
Abstract Background The sphingolipid rheostat – the interconversion between pro-apoptotic ceramide (Cer) and pro-survival sphingosine-1-phosphate (S1P) – governs female reproductive homeostasis. This review integrates mechanistic evidence across the reproductive continuum to elucidate how…
-
Journal Article
Bile Acid Metabolism Regulates Ovarian Function: Networks and Reproductive Health Applications
Abstract Background Bile acids (BAs) are crucial metabolic regulators and signaling molecules involved in lipid metabolism and ovarian function. They primarily affect follicular development, steroidogenesis, and oocyte maturation through systemic circulation and transporter-mediated uptake (e.g…
-
Journal Article
Circulating Tumor Cells: Emerging Frontiers in Cancer Technology
Abstract Background Circulating tumour cells (CTCs) are unique cells that originate from the main tumor site. They circulate in the bloodstream, and are implicated in metastasis, immune evasion and recurrence in various cancers. Associated biomarkers of importance for CTC detection include…