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Breast Cancer Research
Scopus
ISSN 1465-542X · BMC · 1.498 artikel di indeks
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Artikel Jurnal
Distinct genetic profiles of obesity have different effects on breast cancer risk: leveraging Mendelian randomisation to interrogate causal pathways and identify mediating proteins
Abstract Background Obesity is a well-established risk factor for many cancers, but its association with breast cancer remains inconsistent. Obesity is a highly complex and polygenic condition, driven by multiple biological pathways, some of which have been linked to beneficial health effects…
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Artikel Jurnal
Plasma extracellular vesicles reflect response and prognosis in patients with breast cancer undergoing neoadjuvant treatment
Abstract Background Extracellular vesicles (EVs) are emerging as non-invasive biomarkers in cancer, but their role in monitoring the response to neoadjuvant systemic treatment (NST) in patients with breast cancer remains unclear. This study aimed to assess whether EV concentration and surface…
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Artikel Jurnal
Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancer
Abstract Background Cancer-associated fibroblasts (CAFs) are the main constituents of the tumor microenvironment. Several studies have delineated CAF heterogeneity in different types of tumors, however, it is still unknown how the distinct CAF transcriptional profiles are established during tumor…
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Artikel Jurnal
Multiomic profiling of ER-positive HER2-negative breast cancer reveals markers associated with metastatic spread
Abstract Background Metastatic disease is the main cause of breast cancer (BC)-related deaths, but prediction of metastases remains challenging especially in the large and diverse group with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative tumors. Molecular…
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Artikel Jurnal
Putative breast cancer risk variants from populations of South Asian ancestry are under-represented in public variant classification databases
Abstract The majority of publicly available genomics data originates from populations of European ancestry. This limits understanding and detection of inherited genetic risk factors for breast cancer in other populations. To assess the extent to which deficits in knowledge of the genetics of breast…
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Artikel Jurnal
BHLHE22, targeted by deubiquitinating enzyme OTUD3, exerts an antitumor role in triple-negative breast cancer progression via transcriptionally inhibiting CDT1
Abstract Background Basic helix-loop-helix family, member e22 (BHLHE22), a basic helix loop helix transcription factor family member, functions vary in different types of cancer. Currently, its function in triple-negative breast cancer (TNBC) is unclear. Methods The GSE45827 and GSE113865 datasets…
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Artikel Jurnal
Sequential use of PI3K/AKT/mTOR pathway inhibitors alpelisib and everolimus in patients with hormone receptor-positive metastatic breast cancer
Abstract Background Everolimus, an mTOR inhibitor, is FDA-approved with endocrine therapy (ET) for hormone receptor-positive (HR+)/HER2- MBC regardless of PI3K/AKT/mTOR pathway mutation status. Alpelisib, a PI3K inhibitor, is FDA-approved with fulvestrant for PIK3CA-mutant HR+/HER2- MBC. The…
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Artikel Jurnal
Associations of local breast density with patient characteristics and risk of breast cancer among women undergoing diagnostic breast biopsy
Abstract Background Much of the existing literature reporting associations of breast density with breast cancer risk has evaluated the density of the entire breast. However, density is not homogeneously distributed throughout the breast, and tumors are more likely to arise in areas of dense tissue…
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Artikel Jurnal
Development and cross-validation of a novel multi-omic assay to assess locoregional recurrence risk and adjuvant therapy benefit in early-stage hormone receptor positive invasive breast cancer patients
Abstract Purpose Breast cancer management is shifting towards personalized treatment regimens, particularly for early-stage, hormone receptor positive (HR+) invasive breast cancer (IBC) patients following breast conserving surgery (BCS) where locoregional recurrence (LRR) rates are low. A critical…
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Artikel Jurnal
Generational trends in reproductive factors among women in the US: implications for breast cancer incidence
Abstract Background Reproductive factors are key breast cancer risk factors, yet contemporary generational patterns remain unclear. We aimed to evaluate trends in reproductive factors among US women born between 1910 and 2000. Methods We conducted a serial, cross-sectional analysis of reproductive…
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Artikel Jurnal
Premenopausal serum midkine levels and risk of estrogen receptor positive breast cancer: a prospective, nested case–control study
Abstract Background Midkine is a heparin-binding growth factor that is overexpressed in most human malignancies, including breast cancer. While elevated midkine levels have been associated with tumor progression and aging, its role as a predictive biomarker for breast cancer risk in healthy…
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Artikel Jurnal
Association between metabolic dysfunction-associated steatotic liver disease and breast cancer risk in Korean women: a nationwide population-based cohort study
Abstract Purpose Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disorder linked to systemic metabolic imbalance. Although MASLD has been associated with extrahepatic cancers, including breast cancer, evidence is limited, especially among Asian…
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Artikel Jurnal
Recreational physical activity and biomarkers of breast cancer risk in a cohort of adolescent girls
Abstract Background Evidence suggests that recreational physical activity (RPA) during adolescence is associated with lower breast cancer (BC) risk, but the biological mechanisms underlying this relationship remain unclear. We examined the associations between RPA and three BC biomarkers–breast…
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Artikel Jurnal
Tumor heterogeneity index from DCE-MRI for AKT-inhibition responder identification and reveals hot immune microenvironment for patients with breast cancer: a multi-omics analysis of I-SPY2 trial
Abstract Background The pan-AKT inhibitor MK2206 has shown improved but limited efficacy in achieving pathologic complete response (pCR) in patients with breast cancer receiving standard neoadjuvant chemotherapy (NACT). This study aimed to develop non-invasive tumor heterogeneity index (THI) from…
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Artikel Jurnal
Characterization of ESR1 alterations in patients with breast and gynecologic cancers
Abstract Background ESR1 alterations present a common mechanism of resistance to endocrine therapy (ET) in hormonally driven tumors. The clinical significance of these alterations continues to evolve with newly approved targeted therapies and a range of ongoing investigational trials. Methods A…
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Artikel Jurnal
Molecular subtypes of breast cancer in Jamaican women: high prevalence of triple-negative and HER2 + disease
Abstract Background Breast cancer incidence and mortality patterns vary significantly across populations, with women of African ancestry experiencing disproportionately higher mortality despite lower incidence rates. Jamaica reports concerning breast cancer mortality, yet comprehensive molecular…
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Artikel Jurnal
Experimental evaluation of dermal lymphatics in preservation of lymphatic function
Abstract Background Secondary lymphedema is characterized by limb swelling following lymphatic disruption. This results in decreased lymph flow through the collecting ducts and dermal backflow in the subdermal lymphatics. The role of dermal lymphatics in the development of lymphedema is poorly…
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Artikel Jurnal
The spatial immune landscape predicts outcome and reveals the central role of tumor-associated macrophages in inflammatory breast cancer biology
Abstract Background Inflammatory breast cancer (IBC) is a rare but aggressive subtype of breast cancer characterized by rapid progression and poor prognosis. Despite its distinct clinical presentation and molecular features, the immune landscape of IBC and its potential role in driving the…
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Artikel Jurnal
The impact of immune microenvironment on local control of ductal carcinoma in situ receiving breast conservative therapy
Abstract Background This study aims to identify the role of tumor immune microenvironment (IME) in ductal carcinoma in situ (DCIS) in predicting benefit of whole breast irradiation (WBI). Methods Different subtypes of tumor infiltrating lymphocytes (TILs), tumor associated macrophages (TAMs) and…
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Artikel Jurnal
Toxicity profiles of proton and photon radiotherapy in postoperative breast cancer: a 10-year real-world cohort study
Abstract Background Proton therapy, with its superior dose distribution, has emerged as a promising radiotherapy (RT) technique. This study evaluates the clinical benefits of proton therapy in reducing treatment-related toxicities in breast cancer patients undergoing radiotherapy. Methods A…
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