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Respiratory Research
Scopus
ISSN 1465-993X · BMC · 4.636 artikel di indeks
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Artikel Jurnal
LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells
Abstract Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved. The human cathelicidin CHDP, LL-37…
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Artikel Jurnal
Clinical implications of traction bronchiectasis in IPF and fibrotic RA-ILD – a retrospective single-center cohort study
Abstract Background Bronchiectasis is a common feature in idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). While these so-called traction bronchiectasis are often considered a secondary phenomenon in fibrosing ILD, their prognostic…
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Artikel Jurnal
The involvement of Th17 inflammation and miR-363-3p in airway epithelial barrier dysfunction
Abstract Background Impaired airway epithelial barrier function is a pathogenic driver in a subset of individuals with asthma. MicroRNAs, small RNAs that function as post-transcriptional regulators of gene expression, may be involved in the regulation of the airway epithelial barrier. This study…
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Artikel Jurnal
RAAS antagonists dampen the SARS-CoV-2 infection in ex-vivo cultured human precision-cut lung slices
Abstract Background While the renin-angiotensin-aldosterone system (RAAS) is critically involved in pathomechanisms related to SARS-CoV-2 infection, the role of ongoing therapy with angiotensin-converting enzyme 1 inhibitors (ACEi) or Angiotensin-II type 1 receptor (AT1R) blockers (ARB) is much…
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Artikel Jurnal
Systemic and airway T cell dynamics with influenza-specific immune recovery by cystic fibrosis elexacaftor/tezacaftor/ivacaftor therapy
Abstract Background Therapy with elexacaftor/tezacaftor/ivacaftor (ETI) works to improve the functionality of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein and has revolutionized CF treatment. However, the implications of ETI for airway barrier and systemic T cell…
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Artikel Jurnal
Immunophenotypic and structural signatures of severe granulation tissue in airway implant patients
Abstract Background Granulation tissue formation is a frequent complication following airway implant procedures such as endobronchial valve (EBV) therapy in patients with chronic obstructive pulmonary disease (COPD). This hyperplastic response can impair implant function and clinical outcomes, yet…
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Artikel Jurnal
Outcomes after biologic initiation among patients with severe asthma and normal lung function in the CHRONICLE study
Abstract A subset of patients with severe asthma (SA) has normal lung function, defined by a pre-bronchodilator (BD) forced expiratory volume in 1 second (FEV1) of ≥80% of predicted normal value. The effect of biologic treatments on patients with SA and normal lung function is not well understood…
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Artikel Jurnal
Airway microbial compartmentalization under mechanical ventilation: a randomized pilot study comparing an endotracheal tube with suction and continuous cuff pressure control (Venner PneuX®) to standard intubation
Abstract Objectives Ventilator-associated pneumonia (VAP) is driven in part by microaspiration along the endotracheal tube cuff, a process difficult to measure directly in ventilated patients. Because microbial communities differ between airway compartments, changes in their similarity over time…
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Artikel Jurnal
Single-cell RNA sequencing elucidates potential mechanisms of endothelial cells in lung region-specific repair and remodeling in combined pulmonary fibrosis and emphysema
Abstract Background Combined pulmonary fibrosis and emphysema (CPFE) is a severe and progressive lung disease with limited therapeutic options and poor prognosis. CPFE manifests as emphysema and fibrosis in different lung regions and is frequently associated with pulmonary hypertension. Pulmonary…
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Artikel Jurnal
Effect of COVID-19 vaccination and SARS-CoV-2 infection status on mortality risk in patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study
Abstract Background The coronavirus disease 2019 (COVID-19) vaccination is suggested to be effective in improving outcomes of chronic obstructive pulmonary disease (COPD). However, real-world evidence on long-term mortality among individuals with COPD, accounting for both vaccination and COVID-19…
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Artikel Jurnal
Detection of nocturnal desaturation and hypercapnia using accelerometer-integrated pulse oximetry: a prospective observational study
Abstract Background Sleep-related hypoventilation, particularly during rapid eye movement (REM) sleep, has been linked to pulmonary hypertension and recurrent exacerbations in individuals with advanced chronic respiratory or neuromuscular diseases. Overnight pulse oximetry (OPO) serves as a…
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Artikel Jurnal
Comprehensive profiling of lactylation-associated genes in pulmonary hypertension through bulk and single-cell RNA sequencing integration
Abstract Background Pulmonary hypertension (PH) is a progressive disorder with high pulmonary arterial pressure, causing right ventricular dysfunction. Understanding PH’s molecular basis is vital for therapy development, but research on lactylation’s role in PH is limited and needs more…
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Artikel Jurnal
Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity
Abstract Rationale We previously validated five clinically distinct asthma metabo-endotypes (mechanistically derived asthma subgroups). We hypothesize that metabo-endotype membership may be partially driven by differences in serum microRNA profiles and their influence on metabolite levels…
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Artikel Jurnal
GLCCI1 alleviates airway remodeling in asthmatic mice by inhibiting ZEB1-mediated epithelial-mesenchymal transition
Abstract Background Asthma is a heterogeneous disease characterized by chronic airway inflammation and airway hyperresponsiveness. Our previous study found that glucocorticoid-induced transcript 1 (GLCCI1) is down-regulated in the lung tissues of asthmatic mice. This work attempted to determine the…
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Artikel Jurnal
Modulation of the NF-κB signaling pathway by the combined strategy of tocilizumab and dexamethasone for asthma therapy
Abstract Asthma, a prevalent chronic inflammatory airway disease, is conventionally managed with glucocorticoids (GCs) such as dexamethasone (DEX). However, prolonged DEX use induces adverse effects, including immunosuppression and metabolic disruptions. Tocilizumab (TCZ), a humanized monoclonal…
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Artikel Jurnal
Plasma extracellular vesicles-derived MicroRNAs as potential biomarkers in idiopathic pulmonary fibrosis
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with limited treatment options. Despite antifibrotic therapies, IPF prognosis remains poor, with a variable clinical course. IPF pathogenesis involves recurrent epithelial injury, dysregulated wound…
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Artikel Jurnal
Combined effects of mesenchymal stromal cells and antibiotic therapy on Enterobacter ventilator-associated pneumonia in rabbits
Abstract Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a frequent and severe complication in critically ill…
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Artikel Jurnal
Surfactant protein A deficiency aggravates silica-induced pulmonary fibrosis by promoting intrinsic apoptosis of alveolar type II epithelial cells
Abstract Background Silicosis is an incurable occupational lung disease characterized by progressive fibrosis and respiratory failure, imposing a significant global health burden. Surfactant protein A (SP-A) plays a critical role in maintaining pulmonary homeostasis, yet its mechanistic role in…
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Artikel Jurnal
Runx2 acetylation enhances pulmonary inflammation in chronic obstructive pulmonary disease through activating CDK8
Abstract Background Runt-related transcription factor 2 (Runx2), a transcription factor of the RUNX family, is involved in various inflammatory diseases. However, the role of Runx2 was unclear in chronic obstructive pulmonary disease (COPD). Methods Pulmonary Runx2 level was compared in COPD…
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