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EMBO Reports
Scopus
ISSN 1469-3178 · Springer Nature · 894 artikel di indeks
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Artikel Jurnal
Governing the AI–biotech convergence
The convergence of artificial intelligence with biotechnology accelerates innovation but also introduces significant ethical and security risks. These require adaptive, flexible governance strategies that ensure that breakthroughs can be managed responsibly while mitigating potential risks.
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Artikel Jurnal
Give credit where credit is due, also for omics data
The exponentially increasing amount of omics data has created problems regarding ethical use of data generated by others. We address some of these issues and make suggestions on how they could be avoided or solved to ensure an open and fair research environment.
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Artikel Jurnal
Microscopy Nodes: versatile 3D microscopy visualization with Blender
Abstract Effective visualization of 3D microscopy data is essential for communicating biological results. While scientific 3D rendering software is specifically designed for this purpose, it often lacks the flexibility found in non-scientific software like Blender, which is a free and open-source…
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Artikel Jurnal
Signaling roles for astrocytic lipid metabolism in brain function
Abstract Astrocytes, the most abundant glial cell type in the central nervous system, have traditionally been viewed from the perspective of metabolic support, particularly supplying neurons with lactate via glycolysis. This view has focused heavily on glucose metabolism as the primary mode of…
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Artikel Jurnal
From domination to partnership
Despite advances in synthetic biology and ecological understanding, the deployment of engineered microorganisms for bioremediation remains stalled due to outdated containment-centric narratives and regulatory frameworks. A shift from a logic of control to one of care and stewardship, is needed for…
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Artikel Jurnal
Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Abstract Mild rupture of aged erythrocytes occurs in the spleen, resulting in hemoglobin (Hb) release, whereas pathological hemolysis characterizes several diseases. Hb detoxification is attributed to macrophages, but other routes of Hb clearance remain elusive. Here, we uncover that Hb uptake is…
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Artikel Jurnal
TRIM2 E3 ligase substrate discovery reveals zinc-mediated regulation of TMEM106B in the endolysosomal pathway
Abstract TRIM2 is a mammalian E3 ligase with particularly high expression in Purkinje neurons, where it contributes to neuronal development and homeostasis. The understanding of ubiquitin E3 ligase function hinges on thoroughly identifying their cellular targets, but the transient nature of…
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Artikel Jurnal
Distinct Bomanins at the Drosophila 55C locus function in resistance and resilience to infections
Abstract Host defense against many Gram-positive bacteria and fungal pathogens is mainly provided by the Toll-dependent systemic immune response in Drosophila. While antimicrobial peptides active against these categories of pathogens contribute only modestly to protection, Bomanin peptides are…
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Artikel Jurnal
An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA
Abstract Folliculogenesis is a process that requires accurate interpretation of female physiological cues and elaborate coordination between the growing oocyte and its surrounding follicle cells, each being capable of responding to external signals. Here, we investigate the role of insulin…
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Artikel Jurnal
The jam-based discovery framework
Science and music are improvisational acts built on structure, discipline and intuition. And like music, science advances when ideas flow freely, when mistakes become motifs and when everyone in the room listens.
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Artikel Jurnal
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium
Abstract Olfactory dysfunction is a major symptom of COVID-19 syndrome. The critical genes contributing to SARS-CoV-2 infection are not fully understood. Here, we identified Cadherin 1 (CDH1), a hub in the interaction network of viral entry-related genes in human and mouse olfactory epithelium…
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Artikel Jurnal
TDRD5 facilitates piRNA biogenesis and male fertility through phase separation
Abstract piRNAs are small regulatory RNAs with critical roles in transposon silencing and regulation of gametogenesis. Phase separation is a driving force for piRNA biogenesis machinery formation; however, the specific piRNA-related proteins that mediate phase separation and how they coordinate to…
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Artikel Jurnal
Polyunsaturated fatty acid sequestration protects against mitochondrial dysfunction-induced ferroptosis
Abstract Impaired energy production is a hallmark of mitochondrial oxidative phosphorylation (OXPHOS) defects. However, secondary metabolic disturbances also represent an important trigger for pathologies originating from OXPHOS aberrations. Here we show that cells with OXPHOS deficiencies…
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Artikel Jurnal
Local translation of endosome-associated lc3b mRNA in axons contributes to endosomal clearance
Abstract RNA localization to organelles is emerging as a key mechanism for regulating protein expression at the subcellular level in neurons. Although certain transcripts associate with endosomes, the functional significance remains poorly understood. Using APEX-seq, we identify a broad set of…
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Artikel Jurnal
CtBP1/2 restrict DUX-dependent and independent 2C-like programs in mouse embryonic stem cells
Abstract After fertilization, maternally deposited mRNAs are cleared, and de novo transcription is initiated through zygotic genome activation (ZGA), a core event of the maternal-to-zygotic transition in mice. 2-cell-like cells (2CLCs), a rare MERVL-positive subpopulation of mouse embryonic stem…
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Artikel Jurnal
The scientific game
Using game theory, we demonstrate how performance metrics in academic science function as a non-monetary currency that solves the principal-agent problem in science and extracts high efforts from researchers. In light of increasingly scarce resources, these incentives require structural redesign of…
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Artikel Jurnal
The ER–Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses
Abstract The endoplasmic reticulum–Golgi intermediate compartment (ERGIC) is a dynamic membrane system at the ER–Golgi interface, traditionally viewed as a transient station for COPII- and COPI-dependent trafficking. Emerging evidence redefines the ERGIC as a stress-responsive regulatory hub that…
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Artikel Jurnal
IFN-α and IFN-β inhibit NLRP1-driven PANoptosis
Abstract Pathogens, tissue damage, and cellular stress are detected by innate immune sensor molecules to drive inflammatory signaling and cell death. Mutations in the sensor NLRP1 are associated with inflammatory disease, but the regulation of this sensor is not well understood. Here, we find that…
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Artikel Jurnal
How to build reproducibility into scientific publishing
The academic publishing system needs to include replication of key experiments wherever possible to meet the replication crisis. A major challenge is to incentive validation and provide funding for it.
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Artikel Jurnal
Mannose supports lung cancer metabolism during glycolytic limitation
Abstract Cancer cells frequently show elevated glucose consumption to support proliferation and survival. This led to the assumption that glycolytic inhibitors could be effective in cancer treatment. However, barriers to clinical implementation remain. Adaptive strategies, such as metabolizing…