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Experimental Physiology
Scopus
ISSN 1469-445X · Wiley · 924 artikel di indeks
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Artikel Jurnal
Long‐term endurance running training and testosterone daily variation in ageing men; a comparative cross‐sectional study
Abstract The aim of this study was to assess the relationship between long‐term endurance running training and daily variation in testosterone, which is known to diminish during ageing, in a comparative, cross‐sectional study. We recruited 45 male participants into four groups [young athletes (YA)…
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Artikel Jurnal
Plasma β‐hydroxybutyrate concentrations in young adult females after a high‐fat meal under normoxaemia, intermittent hypoxaemia and continuous hypoxaemia: An exploratory analysis
Abstract Hypoxaemia occurs in intermittent forms, such as obstructive sleep apnoea, and in continuous forms, such as at high altitude, and is increasingly recognized as a modulator of cardiometabolic risk. Although hypoxaemia alters postprandial glucose and lipid metabolism, its effects on ketone…
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Intermittent low‐intensity contractions cause a dissociation between maximal motor unit firing rates and changes in torque and contractile speed
Abstract The purpose was to test: (1) whether the decline in maximal motor unit (MU) firing rate is an invariable response when maximal voluntary contraction (MVC) torque is reduced following a submaximal muscle fatiguing task; and (2) whether fatigue‐induced slowing of contractile speed and firing…
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FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress
Abstract Doxorubicin (DOX) is a potent anthracycline chemotherapeutic agent, but its clinical use is limited by cumulative cardiotoxicity. Exercise, particularly high‐intensity interval training (HIIT), has emerged as an effective non‐pharmacological strategy to counteract chemotherapy‐induced…
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Artikel Jurnal
Haemodynamic effects of selective venoconstriction with centhaquine in spontaneously breathing patients with mixed hypovolaemic‐vasodilatory shock
Abstract Circulatory shock remains difficult to manage because fluid resuscitation and catecholamines may exacerbate vascular dysfunction and tissue hypoperfusion. This prospective physiological analysis, embedded within a multicentre phase IV study, examined whether selectively targeting the…
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Circulating granulocyte colony‐stimulating factor as a sex‐unbiased global marker of lung and colorectal cancer cachexia pre‐clinical models
Abstract Cancer cachexia, affecting up to 80% of patients with advanced cancer, is characterized by metabolic and inflammatory dysregulation driven by tumour‐ and host‐derived factors. Although cytokines are central to cachexia pathogenesis, their circulating profiles and transcriptional relevance…
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Effects of exercise in a fed or fasted state on mitochondrial dynamics regulators in the skeletal muscle of recreationally active males
Abstract Exercise and nutritional modulation favourably alter mitochondrial quantity and quality in skeletal muscle. Mitochondrial dynamics, the coordination of fission and fusion events, are poised to mediate key aspects of organelle adaptation that arise from exercise. However, the molecular…
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Six weeks of high‐intensity interval training improve autonomic and metabolic responses in active postmenopausal women
Abstract This study analysed the effects of a supervised high‐intensity interval training (HIIT) programme on metabolic flexibility and autonomic function in active postmenopausal women. Twenty women (66.6 ± 6.2 years; 67.9 ± 11.1 kg) completed a 6‐week cycling HIIT intervention consisting of three…
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Elevation of body temperature during exercise enhances protection against dexamethasone‑induced skeletal muscle atrophy
Abstract Prolonged glucocorticoid exposure induces skeletal muscle atrophy through suppression of protein synthesis and activation of catabolic signalling pathways. Although exercise attenuates glucocorticoid‐induced muscle loss, whether exercise‐induced increases in body temperature contribute…
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Traumatic arteriovenous fistula after ice axe injury 27 years ago: A case report
Abstract We report a case of a traumatic arteriovenous fistula (AVF) between the superficial femoral artery and femoral vein that went undetected for 27 years following an ice axe injury during a climbing accident in 1997. An AVF is an abnormal connection between an artery and a vein, where blood…
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Artikel Jurnal
Physiological and autonomic responses to intermittent low‐lung‐volume apnoea and pain sensitivity: A randomized controlled pilot trial
Abstract Intermittent apnoeas may induce hypoalgesia; however, the effects of low‐lung‐volume static apnoea have not been investigated. Eighty healthy participants were randomized to an apnoea group (AG) or a control group (CG). The AG performed a 6‐min protocol of intermittent static apnoea at low…
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Pathophysiology of the gut–eye axis in a Sjögren's disease‐like dry eye mouse model: An exploratory evaluation of dietary heat‐treated Enterococcus faecalis FK‐23
Abstract Sjögren's disease is an autoimmune disease characterized by severe dry eye, but its pathophysiology remains unclear. Non‐obese diabetic (NOD) mice develop Sjögren's disease‐like dry eye prior to the onset of diabetes. Although intestinal immune abnormalities precede diabetes in NOD mice…
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Artikel Jurnal
Feedback from group III/IV afferents in skeletal muscle slows heart rate acceleration when transitioning from rest to low‐intensity exercise in males
Abstract Group III/IV skeletal muscle afferents respond to intramuscular mechanical and metabolic stimuli and are more active in fatigued muscle. These afferents project onto the brainstem and motor cortex and modulate cardiovascular and motor responses during exercise. The maximal rate of heart…
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Intensity‐dependent ventilatory and cardiopulmonary patterns during exercise in trained individuals with cerebral palsy: An exploratory study
Abstract Cerebral palsy (CP) is associated with altered exercise physiology, but it remains unclear how ventilatory and cardiopulmonary responses are expressed under high physiological demand in individuals with CP. Six athletes with CP (spastic CP: n = 3, all GMFCS III, all male, mean age 24…
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Acute exercise‐induced lipolysis and increase in levels of fatty acid esters of hydroxy fatty acids in adipose tissue are impaired in obese and aged mice
Abstract Improving adipose tissue (AT) metabolism through exercise might increase production of lipokines from the fatty acid esters of hydroxy fatty acids (FAHFA) family. Although exercise training can increase insulin sensitivity and levels of specific FAHFA in AT and the circulation in humans…
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Muscle cramp susceptibility is associated with muscle‐specific modulation of human motoneuron discharge patterns
Abstract Muscle cramps are painful, involuntary contractions thought to arise from altered spinal motoneuron excitability, potentially involving persistent inward currents (PICs). We examined whether cramp susceptibility is associated with altered PIC‐related motoneuron behaviour and whether…
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Clinical and biochemical factors associated with insulin therapy in gestational diabetes: The role of OGTT‐based groups
Abstract Gestational diabetes mellitus (GDM) represents one of the most common metabolic disorders of pregnancy. This study aimed to identify clinical and biochemical factors associated with antenatal insulin therapy, focusing on the association with oral glucose tolerance test (OGTT)‐based…
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Artikel Jurnal
Splenic contraction associated with sudden, transient hypotension and sympathoexcitation in humans
Abstract The spleen is traditionally recognised for its roles in immunity and blood filtration, and it is known to contract and release stored erythrocytes in hypoxic conditions. Recent findings suggest that the spleen may also contribute to cardiovascular regulation. This study investigated…