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BMC Immunology
Scopus
ISSN 1471-2172 · BMC · 1.174 artikel di indeks
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Artikel Jurnal
Lactate dehydrogenase to albumin ratio as a convenient parameter for predicting the severity of Behçet disease: a cross-sectional study
Abstract Background We investigated whether the ratio of lactate dehydrogenase (LDH) to albumin could be used as a diagnostic marker for Behçet’s disease compared to the healthy population and as a marker to assess the severity and activity of the disease. Methods The research was conducted as a…
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Artikel Jurnal
TZ1391: a computationally designed circular mRNA multi-epitope vaccine candidate against Mycobacterium tuberculosis via TLR3 immunomodulation
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health burden due to latent infection, multidrug resistance, and the limited efficacy of the BCG vaccine. To address this challenge, we computationally designed and evaluated a circular mRNA-based multi-epitope…
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Artikel Jurnal
Establishment of age-specific reference intervals for peripheral blood SII, NLR, PLR, and LMR in healthy children
Abstract Objective To establish and validate age-specific reference intervals for the peripheral blood systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in healthy children. Methods A total of…
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Artikel Jurnal
Polypore mushroom mycelia as an adjunct to COVID-19 vaccination: a randomized clinical trial
Abstract Background Use of fungal mycelium as a vaccination adjunct may constitute a novel antiviral strategy to address newly emerging viruses. We evaluated safety and feasibility of a fungal mycelium-based natural product (Fomitopsis officinalis and Trametes versicolor, FoTv) as an adjunct to…
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Artikel Jurnal
Comparative efficacy and safety of IL-17 and IL-23 inhibitors for moderate-to-severe psoriasis in Asian populations: a systematic review and meta-analysis
Abstract Background Psoriasis is a chronic inflammatory skin disorder affecting a significant portion of the global population. Biologics targeting the IL-17 and IL-23 pathways are effective in treating moderate-to-severe psoriasis; however, most clinical trials have been conducted in Western…
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Artikel Jurnal
Dysfunction of the plasmacytoid dendritic cells in enterovirus 71-induced HFMD affecting children
Abstract The role of Plasmacytoid Dendritic Cells (pDCs) in Enterovirus-71 (EV71)-induced Hand, Foot, and Mouth Disease (HFMD) remains unclear. In this study, we investigated pDCs in severe HFMD patients infected with EV71. Flow cytometry revealed reduced pDC percentage in severe patients compared…
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Artikel Jurnal
Saussurea involucrata oral liquid alleviates joint inflammation in CIA rats by modulating macrophage polarization and glucose metabolism
Abstract Objective To evaluate the therapeutic effects of Saussurea involucrata Oral Liquid (SIOL) in a collagen-induced arthritis (CIA) rat model. Methods This study was conducted from April 2023 to June 2024. Sixty male SPF SD rats were randomly divided into six groups: control, model…
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Artikel Jurnal
Retrospective, single-center analysis of autoimmune hepatitis in Yemeni adults: clinical features, treatment, and outcomes
Abstract Background Autoimmune hepatitis (AIH) is a chronic liver disease in which the immune system of the body unintentionally targets liver cells, resulting in inflammation, liver damage, and cirrhosis if treatment is not received. Although the precise origin of AIH remains unknown, experts…
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Artikel Jurnal
Upregulation of miR-223 by SIRT1 attenuates the inflammatory response in neonatal sepsis
Abstract Background The diversity of clinical symptoms of neonatal sepsis leads to difficulties in diagnosis, and the treatment is limited. This study aims to investigate the role of the SIRT1/miR-223 signaling axis in neonatal sepsis. Methods 100 neonates with sepsis and 100 healthy infants were…
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Artikel Jurnal
Analysis of risk factors of coronary artery lesions in Kawasaki disease and study of IVIG treatment response
Abstract Background Kawasaki disease (KD) is an acute vasculitic disease of unknown etiology, which mostly occurs in infants and young children. Coronary artery lesions (CAL) are an important complication, mainly in patients who are not treated with intravenous immunoglobulin (IVIG) in time or who…
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Artikel Jurnal
Brain radiotherapy combined with immune checkpoint inhibitors and chemotherapy as first-line treatment for advanced non-small cell lung cancer with brain metastases: a retrospective study
Abstract Background Brain metastasis (BM) remains a major therapeutic challenge in non-small cell lung cancer (NSCLC) without actionable driver mutations. Radiotherapy combined with immune checkpoint inhibitors (ICIs) may enhance intracranial control through synergistic immune activation. This…
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Artikel Jurnal
The impact of yak versus cow milk on exercise-induced allergy and performance in sensitized mice
Abstract Background Dairy consumption is a common cause of food allergies, driving interest in alternative sources like yak milk (YM). This study aimed to evaluate and compare the effects of dietary supplementation with YM and cow milk (CM) on immune sensitization, exercise-induced allergic…
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Artikel Jurnal
Association between gut microbiota-derived TMAO, systemic inflammatory markers, and echocardiographic findings in patients with common variable immunodeficiency
Abstract Background Common Variable Immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency in adults. While infections are common, over 50% of patients exhibit autoimmune and immune activation related complications. Chronic inflammation from dysbiosis may affect the heart…
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Artikel Jurnal
The correlation between the systemic immune-inflammation index and relapse and metastasis in cervical squamous cell carcinoma patients over 50 years and older
Abstract Objective The aim of this study was to confirm the association of systemic immune-inflammation index (SII) with relapse and metastasis of cervical squamous cell carcinoma (CSCC) in patients over 50 years and older. Methods This retrospective study included 470 patients aged 50 years and…
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Artikel Jurnal
Infused PMN-MDSCs from G-CSF–mobilized PBSCs protect against II–IV° acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Abstract Background Myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cells. Their role in modulating acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. This study aimed to investigate the impact of…
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Artikel Jurnal
The efficacy analysis of immunotherapy rechallenge after progression from first-line chemo-immunotherapy in advanced non-small cell lung cancer
Abstract Introduction Combining immune checkpoint inhibitors (ICI) with chemotherapy has been established as the standard first-line (1 L) treatment for advanced non-small cell lung cancer (NSCLC). However, the optimal second-line (2 L) treatment following 1 L chemo-immunotherapy remained…
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Artikel Jurnal
Diagnostic and prognostic value of deregulated miR-6822-3p in patients with severe pneumonia
Abstract Background Pneumonia is a common cause of morbidity and mortality, with severe cases often progressing to complications such as sepsis and respiratory failure. Early diagnosis and intervention are crucial for improving outcomes. MicroRNAs (miRNAs) have been identified as potential…
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Artikel Jurnal
Phylogeny-guided multi-epitope vaccine design targeting conserved and divergent regions of Brucella OMP2, OMP25, and OMP31: an immunoinformatics study
Abstract Brucella is a zoonotic intracellular bacterial pathogen. Currently, no human vaccines for brucellosis are approved, and only animal vaccines are available. Despite the widespread use of live attenuated vaccines, several drawbacks have prompted investigation into outer membrane proteins…
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