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BMC Microbiology
Scopus
ISSN 1471-2180 · BMC · 6.243 artikel di indeks
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Artikel Jurnal
Whole-genome analysis and fermentation-metabolite profiling of a cellulolytic Arthrobacter sp. FMD isolated from forest musk-deer faeces
Abstract Most studies on the intestinal microbiota of the forest musk deer (Moschus berezovskii) are based on community-level sequencing, and functional characterisation of individual strains is rare. Here we isolated strain FMD from deer faeces by selecting on CMC-Na as the sole carbon source; it…
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Artikel Jurnal
Carbapenemase-mediated resistance in Acinetobacter baumannii clinical isolates: molecular epidemiology and antimicrobial potential of chitosan nanoparticles
Abstract Antibiotic resistance is an escalating global health concern, and Acinetobacter baumannii remains one of the most challenging multidrug-resistant pathogens. This study investigated the prevalence of key carbapenemase genes among clinical A. baumannii isolates and evaluated the…
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Artikel Jurnal
Fosfomycin at sub-minimum inhibitory concentration impairs biofilm and efflux pump activity in multidrug-resistant Klebsiella pneumoniae isolates
Abstract Background Klebsiella pneumoniae plays a critical role in hospital-acquired infections, which pose a serious threat globally. Older antibiotics such as fosfomycin are being reconsidered to combat MDR K. pneumoniae. In healthcare settings, bacteria are exposed frequently to antibiotics at…
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Artikel Jurnal
Population-specific dysbiosis of the salivary microbiota in Saudi adults with periodontitis
Abstract Background To characterize the dysbiosis of salivary microbiota in Saudi adults with periodontitis and identify potential population-specific microbial signatures. Methods Saliva samples were collected from 96 Saudi adults, including 50 patients with periodontitis and 46 control…
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Artikel Jurnal
Prophylactic and therapeutic efficacy of Acinetobacter phage RM_A1 against carbapenem-resistant Acinetobacter baumannii with no cytotoxicity to human skin cells
Abstract Background The rise in multidrug-resistant (MDR) bacteria has rendered common first- and last-line antibiotics ineffective, posing a serious threat to human health. Additionally, the global rise of wound infections caused by carbapenem-resistant Acinetobacter baumannii indicates that the…
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Artikel Jurnal
Large-genome phage vB_Eco_ZCEC15 targets gastrointestinal MDR E. coli: evidence from in vitro and Caco-2 cell models
Abstract Background Bacterial resistance to traditional antibiotics is spreading at an alarming rate, threatening public health and various industrial applications. Phage therapy has emerged as a promising alternative for combating multidrug-resistant (MDR) bacterial infections. However, most…
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Artikel Jurnal
Prevalence and antimicrobial susceptibility profile of Staphylococcus aureus from meat, abattoir workers, equipment and water samples at Abergelle International Livestock Development PLC, Mekelle, Northern Ethiopia
Abstract Background Raw meat is one of the main sources of food borne infections worldwide. Staphylococcus aureus (S. aureus) is one of the key organisms that is prevalent in contaminated meat, having different patterns of antimicrobial susceptibility to different antibiotics. This study aimed to…
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Artikel Jurnal
Impact of TNF-α (− 308G>A and − 857 C>T) promoter variants on susceptibility to chronic hepatitis B virus infection in a cohort of Mauritanian patients: pilot study
Abstract Background Genetic polymorphisms within the tumor necrosis factor (TNF) cluster have been implicated in several diseases. This exploratory study aimed to assess the role of two polymorphisms (− 308G > A and − 857 C > T) in the TNF-α gene in the risk of developing chronic Hepatitis B virus…
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Artikel Jurnal
Antimicrobial metabolites of the intestinal fungus Trichoderma sp. QTYC44 from Pantala flavescens larvae
Abstract Background Insect gut fungi are increasingly recognized as specialized microbial reservoirs of bioactive compounds, yet the insect-associated microbes of Pantala flavescens larvae remain understudied. Results In this study, the intestinal fungus Trichoderma sp. QTYC44, previously isolated…
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Artikel Jurnal
A real-world evidence of sputum microbiota alterations and their association with oncogenomic changes and response to targeted therapies in patients with lung cancer
Abstract Objective Alterations to the respiratory microbiota may contribute to lung cancer progression. This study examined real-world data to characterize sputum microbiota alterations and to assess their association with oncogenomic changes and response to targeted therapies in patients with lung…
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Artikel Jurnal
First isolation and molecular confirmation of Brucella canis in dogs from Egypt
Abstract Background Brucellosis, a disease of major veterinary and public health concern, remains widespread in several regions, including Egypt. This study reports the isolation and molecular confirmation of Brucella canis from dogs in Egypt and provides genetic relatedness of Brucella melitensis…
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Artikel Jurnal
Comparative metagenomic characterization of gut microbiota and antibiotic resistome in multi-facility SPF mice
Abstract Specific pathogen-free (SPF) mice are pivotal preclinical models linking basic microbiology to clinical translation, yet comprehensive high-resolution profiling of their gut microbiome, especially antibiotic resistance genes (ARGs), remains limited. To address this gap, metagenomic…
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Artikel Jurnal
Purification, and characterization of xylanase by Aspergillus krugeri AUMC 15912 utilizing sugarcane bagasse under solid-state fermentation conditions
Abstract This study focuses on optimizing, purifying, and characterizing xylanase produced by Aspergillus krugeri AUMC 15912 utilizing sugarcane bagasse under solid-state fermentation (SSF). The strain, isolated from sugarcane bagasse, exhibited significant xylanase activity, which was maximized…
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Artikel Jurnal
Gut microbiota mediates the beneficial effects of exercise on autism-like behaviors
Abstract Background The gut-brain axis plays a critical role in autism spectrum disorder (ASD), but the mechanisms through which exercise modulates gut microbiota, short-chain fatty acids (SCFAs), and central neurotransmitters to ameliorate ASD-like behaviors remain unclear. This study aimed to…
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Artikel Jurnal
Fatty acids from Hermetia illucens larvae disrupt membrane integrity in colistin-resistant Acinetobacter baumannii
Abstract Background The overuse and prolonged application of antibiotics have led to the emergence of multidrug-resistant bacterial pathogens, notably Acinetobacter baumannii, a leading cause of nosocomial infections and increased mortality in healthcare settings. In natural conditions, fatty acids…
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Artikel Jurnal
Transcriptomics combined with metabolomics to elucidate the mechanisms of bacterial otitis media infection: insights from mitochondrial dysfunction
Abstract Background Lipopolysaccharide (LPS) is a key pathogen-associated molecular pattern that triggers inflammatory diseases such as otitis media (OM). However, the core mechanisms by which LPS leads to epithelial cell damage, specifically through the regulation of cellular metabolism and…
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Artikel Jurnal
Antibacterial activity and mechanism analysis of deoxycholic acid against Clostridium perfringens
Abstract Background Deoxycholic acid (DCA), a gut microbiota-derived secondary metabolite, exhibits broad-spectrum antimicrobial activity, particularly against Clostridium perfringens(C. perfringens). However, its specific antibacterial mechanism remains unclear. Objective To investigate the…
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Artikel Jurnal
Exploring microbial and metabolite composition of the external mucus of wild Mediterranean sparids: is there a link with their monogenean ectoparasites?
Abstract Background External mucus forms a complex interface that constitutes the first line of defense in teleost fish. In addition to host-derived molecules, this mucus harbors bacterial communities capable of producing a wide range of bioactive compounds. The structure and function of these…
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Artikel Jurnal
Research on the process of synergistic degradation of corn straw by probiotics—enzymes based on microbiome and metabolomics
Abstract Background Probiotics enzyme co-fermentation significantly improves the use efficiency and nutritional value of crop straw, although the underlying synergies are not clear. Methods The experiment used corn straw as the raw material. It was treated with a 0.2% composite enzyme preparation…
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Artikel Jurnal
Analysis of nontuberculous mycobacteria laboratory detection data from a designated hospital in Henan Province, China
Abstract Background Nontuberculous mycobacteria (NTM) infections are emerging globally, yet epidemiological data from central China remain limited. This study analyzed mycobacterial culture and identification data from Henan Provincial Chest Hospital (2020–2024) to assess NTM detection patterns and…
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