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BMC Gastroenterology
Scopus
ISSN 1471-230X · BMC · 5.288 artikel di indeks
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Artikel Jurnal
Downregulation of MUC6 improves esophageal epithelial barrier dysfunction and inhibits epithelial-mesenchymal transition in reflux esophagitis
Abstract Background Reflux esophagitis (RE) is a chronic inflammatory condition resulting from the reflux of gastric contents. Mucin 6 (MUC6), a member of the mucin family, has been found to have dysregulated expression in various esophageal diseases. However, the specific role of MUC6 in RE…
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Artikel Jurnal
Influences of transcutaneous neuromodulation on fecal microbiota and short chain fatty acids in patients with functional constipation
Abstract Objectives Transcutaneous neuromodulation (TN) has been reported effective for functional constipation (FC). The underlying mechanism remains unclear. In this study, we aimed to investigate the gut microbiota (GM) and short chain fatty acids (SCFAs) metabolism changed in FC patients due to…
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Artikel Jurnal
Impact of partial hepatectomy versus other major abdominal surgeries on postoperative myocardial injury: a propensity score-matched analysis
Abstract Background Partial hepatectomy (PH) may increase the risk of myocardial injury after non-cardiac surgery (MINS), a complication associated with substantial perioperative morbidity and mortality. Direct comparisons of MINS incidence between PH and other major abdominal surgeries (MAS)…
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Artikel Jurnal
Characterization of neuroendocrine cell hyperplasia in autoimmune gastritis: improving H&E-based diagnosis through systematic training
Abstract Background The incidence of autoimmune gastritis (AIG) is low, and our understanding of the proliferation of neuroendocrine cells, specifically enterochromaffin-like (ECL) cells, is insufficient because of the reliance on chromogranin A (CgA) staining for diagnostic assistance. The purpose…
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Artikel Jurnal
Effects of age and drug use on lower gastrointestinal bleeding: a retrospective single-center experience
Abstract Background and aims Lower gastrointestinal bleeding is a prevalent issue in the general population, particularly among older adults. Identifying risk factors is essential for improving healthcare outcomes. This study seeks to evaluate the clinical outcomes related to the use of medications…
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Artikel Jurnal
Serum aberrant expression of miR-331-3p and its diagnostic value in severe pancreatitis
Abstract Background Severe acute pancreatitis (SAP) is characterized by persistent organ failure and a high mortality rate, early diagnosis and disease assessment are crucial for improving patient prognosis. Aims To investigate the expression level, diagnostic value, and mechanism of action of…
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Artikel Jurnal
The mediating role of resilience in the relationship between cognitive flexibility and psychological well-being in patients with irritable bowel syndrome: a cross-sectional study
Abstract Background Irritable bowel syndrome (IBS) is one of the most common brain–gut interaction disorders, characterized by chronic abdominal pain, altered bowel habits, and heightened stress responses that significantly affect patients’ psychological functioning and quality of life. Given that…
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Artikel Jurnal
Leptin, vitamin D, and APRI values during the six months post-liver transplantation
Abstract Background Liver fibrosis is a common outcome of chronic liver disease, characterized by accumulating extracellular matrix proteins. Aims: While the gold standard in the assessment of liver fibrosis remains liver biopsy, non-invasive methods have been increasingly used for estimating liver…
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Artikel Jurnal
The impact of gastroesophageal reflux disease in East Asia and China between 1990 and 2021: insights from the 2021 global burden of disease research
Abstract Background Gastroesophageal reflux disease (GERD) is a common chronic digestive disorder with a growing epidemiological footprint worldwide. However, the specific characteristics and burden of GERD in East Asia, particularly in China, remain insufficiently documented. Methods This study…
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Artikel Jurnal
Transjugular liver biopsy in patients with unexplained liver dysfunction and bleeding tendency: a safety and efficacy analysis
Abstract Background Transjugular liver biopsy (TJLB) enables histopathological diagnosis of liver disease and simultaneous assessment of the hepatic venous pressure gradient (HVPG). Aims To assess the diagnostic adequacy and safety of TJLB in combination with HVPG measurement in patients with…
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Artikel Jurnal
Evaluation of efficacy of a polyglycolic acid sheet in laparoscopic gastrectomy for gastric cancer: a single-center retrospective study
Abstract Background Gastric cancer (GC) is one of the most common causes of cancer-related deaths worldwide. Gastrectomy with lymph node dissection is the standard treatment for GC worldwide. Due to advancements in surgical techniques, the use of laparoscopic gastrectomy (LG) has broadened…
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Artikel Jurnal
Laryngopharyngeal reflux current developments and therapeutic strategies
Abstract Laryngopharyngeal reflux (LPR) is reflux of gastric contents proximal to the upper esophageal sphincter and leading to a variety of symptoms including cough, dysphonia, globus, and sore throat. There is currently no diagnostic gold standard for LPR which often leads to over or under…
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Artikel Jurnal
Risk factors for significant hepatic fibrosis in alcoholic liver disease and construction of a nomogram prediction model
Abstract Background Significant fibrosis represents a critical stage in the progression of Alcoholic Liver Disease (ALD) to cirrhosis. Early identification of significant hepatic fibrosis is crucial for treatment and prognosis. This study aims to investigate risk factors for significant hepatic…
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Artikel Jurnal
Recompensation following first decompensation in patients with alcohol-related cirrhosis
Abstract Background The Baveno VII consensus recently introduced the term “recompensated cirrhosis,” but its prognostic relevance in alcohol-related cirrhosis remains unclear. This study aims to analyze the frequency and associated factors of recompensation in patients with alcohol-related…
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Artikel Jurnal
Sex- and mouse strain-related differences in body weight gain, composition of the gut microbiota, and levels of selected metabolites in response to a Western-style diet
Abstract Background Recent studies reveal an association between the mitochondrial Amidoxime Reducing Component (MTARC) 1 and 2 proteins and metabolism in Mtarc1/2-deficient mice that are resistant to diet-induced obesity; however, the impact of Mtarc1/2 knockout (KO) on the gut microbiota and…
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Artikel Jurnal
Probiotics as emerging adjuncts in metabolic associated fatty liver disease therapy-a systemic review
Abstract Metabolic associated fatty liver disease (MAFLD), a leading cause of chronic liver disorders globally, is closely linked with the dysbiosis of the gut. These microbial imbalances contribute to pathogenesis of MAFLD through intestinal barrier dysfunction, systemic inflammation, and hepatic…
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Artikel Jurnal
Knowledge on modes of hepatitis B transmission and the practice of family screening and vaccination among patients with chronic hepatitis B infection at a tertiary center in Ethiopia
Abstract Background Hepatitis B infection remains an important global public health problem. Screening and vaccination of family contacts are among the key interventions to control hepatitis B. The objective of this study was to assess the knowledge on modes of transmission of hepatitis B and the…
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Artikel Jurnal
Artemether as a modulator of EMT in colorectal cancer: enhancing radiosensitivity and reversing chemo-radiation resistance
Abstract Background The efficacy of conventional chemoradiotherapy for colorectal cancer is often limited by resistance, with epithelial-mesenchymal transition being a key mechanism. Although the artemisinin derivative artemether (ARE) has shown antitumor potential, it remains unclear whether it…
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Artikel Jurnal
Automatic processing of gastrointestinal endoscopy referrals and patient instructions using large language models
Abstract Background Open-access endoscopy relies on referrals that are manually vetted, which is a resource consuming process, with potential biases. While Large Language Models (LLMs) have demonstrated potential in medical utilities, their ability to autonomously manage complex referral logistics…
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Artikel Jurnal
Environmental enteric dysfunction in well-nourished and undernourished women in Bangladesh
Abstract Introduction Environmental Enteric Dysfunction (EED) is a subacute inflammation of the small intestinal (SI) mucosa associated with undernutrition and perturbation of the SI microbiota. Its diagnosis relies on histopathological assessment of small intestinal biopsies, with a lack of…
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