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BMC Nephrology
Scopus
ISSN 1471-2369 · BMC · 5,082 articles in the index
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Journal Article
Analysis of high glucose injury using human induced pluripotent stem cell-derived kidney organoids
Abstract Background Diabetic kidney disease (DKD) is one of the most pervasive complications of diabetes worldwide. However, the pathogenesis of DKD remains poorly understood, due to limitations of the models. The hPSC-derived kidney organoids may offer a new possibility to solve the problem…
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Journal Article
Timing of acute kidney injury in infarction-related cardiogenic shock: early onset signals a high-risk phenotype – a retrospective observational study
Abstract Background Acute kidney injury (AKI) is common in cardiogenic shock (CS) and increases mortality, but the prognostic impact of onset timing in infarct-related CS is unclear. We examined whether early versus late AKI onset is associated with differences in patient characteristics and…
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Journal Article
A narrative review of routine haematological and biochemical parameter monitoring in maintenance haemodialysis patients and comparison of clinical guidelines
Abstract Routine monitoring of haematological and biochemical parameters is essential in managing people with kidney failure on maintenance haemodialysis (HD), guiding assessment of HD adequacy and kidney failure-associated complications, including anaemia, chronic kidney disease-mineral and bone…
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Journal Article
Diagnosis and treatment of complement-mediated thrombotic microangiopathies: consensus of the Genetic Diseases Committee of the Chilean Society of Nephrology
Abstract Thrombotic microangiopathy (TMA) is a clinical-pathological syndrome defined by microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction, commonly affecting the kidneys. The etiologies are diverse and include genetic disorders (affecting complement proteins or other…
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Journal Article
Living with haemodialysis in Sri Lanka: a qualitative study on patient adaptation and care perceptions
Abstract Background The increasing prevalence of individuals undergoing haemodialysis (HD) compels the necessity of person-centred care to minimise treatment-related complications and improve the quality of life. Although the person-centred approach has been widely discussed, it remains…
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Journal Article
L-Carnitine, a new biomarker screened based on untargeted metabolomics, predict cardiac surgery-associated acute kidney injury: a prospective cohort study
Abstract Background This study aims to evaluate the diagnostic potential of L-carnitine (LC) for the early detection of cardiac surgery-associated acute kidney injury (CSA-AKI). Methods We collected clinical data and serum samples from 27 patients admitted to the Intensive Care Unit (ICU) of…
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Journal Article
Automated CT segmentation of kidneys successfully quantifies changes in total kidney volume in ICU patients, a retrospective cohort study
Abstract Background Kidney function is associated with kidney volume. This study aims to explore automated segmentation for measuring total kidney volume (TKV) and to analyse the association between (changes in) TKV and acute kidney injury (AKI) incidence and/or severity in Intensive Care Unit…
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Journal Article
Renal osteodystrophy in Egyptian CKD patients: observations from clinically indicated bone biopsies
Abstract Background Renal osteodystrophy (ROD) varies among populations. Different genetic and environmental factors and prescription patterns may explain this variation. Egyptian ROD is not sufficiently studied. Although bone biopsy is the gold standard tool, no single study reported the actual…
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Journal Article
Renal microthrombosis and thrombomodulin deficiency in COVID-19–associated acute kidney injury
Abstract Background Severe COVID-19 frequently involves multi-organ dysfunction, including acute kidney injury (AKI), which affects up to 85% of critically ill patients. While both direct viral infection and systemic effects are implicated, the role of renal microthrombosis remains poorly defined…
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Journal Article
Veverimer in treating metabolic acidosis in chronic kidney disease patients: a systematic review and meta-analysis of randomized clinical trials
Abstract Introduction Chronic kidney failure (CKD), a common cause of mortality, impacts about 800 million individuals globally. Metabolic acidosis, which occurs in 20% of people with CKD, complicates the course of CKD and increases the possibility of morbidity and mortality in these patients…
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Journal Article
The accuracy of ultrasound viscoelastic imaging in evaluating renal fibrosis and interstitial inflammation of chronic kidney disease
Abstract Background Accurate evaluation of renal fibrosis and interstitial inflammation grades is necessary to improve the prognosis of patients with chronic kidney disease (CKD). However, non-invasive and accurate diagnostic methods are lacking. In this regard, shear wave elastography, which…
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Journal Article
Predictive role and clinical correlation of copeptin in patients with type 2 diabetes mellitus associated nephropathy approaching end-stage renal disease
Abstract Background Diabetic Kidney Disease (DKD) is the leading cause of End Stage Renal Disease (ESRD). Arginine Vasopressin (AVP) plays pivotal roles in osmoregulation and renal water conservation. As patients with DKD are prone to develop osmotic irregularities, AVP is therefore, a potential…
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Journal Article
Hemodialysis versus peritoneal dialysis in elderly ESRD patients: a retrospective cohort study on survival and the role of comorbidities
Abstract Objective To compare survival differences between hemodialysis (HD) and peritoneal dialysis (PD) in elderly patients (≥ 60 years old) with end-stage renal disease (ESRD), and to analyze the impact of key comorbidities (heart failure, cerebrovascular disease, diabetes) on prognosis and…
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Journal Article
A longitudinal prospective study investigating serial measurements of plasma neutrophil gelatinase-associated lipocalins (NGAL) for the prediction of chronic kidney disease and acute kidney injury in emergency department patients
Abstract Background and hypothesis Acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with high morbidity. Current diagnostic markers, e.g., creatinine (Cr) and estimated glomerular filtration rate (eGFR), lack precision in early kidney disease detection. Neutrophil…
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Journal Article
Organ-preserving management of chronic renal hydatid cyst with 10-year asymptomatic progression: a case report
Abstract A 41-year-old male presented with a 10-year history of incidentally discovered left renal cystic lesions on routine examination. Preoperative contrast-enhanced CT and MRI demonstrated multiloculated cystic masses (10 × 8 cm and 10 × 5 cm) suggestive of hydatid disease, with renal…
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Journal Article
Efficacy of semaglutide in IgA nephropathy with obesity: a case report
Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) like semaglutide are well-used for type 2 diabetes and obesity, and recent studies show their potential renal benefits in both diabetic and non-diabetic people. However, evidence for semaglutide’s efficacy in IgAN especially…
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Journal Article
Incidence and risk factors of acute kidney injury after myocardial infarction; a prospective cohort study with impact of timing of presentation on other risk factors
Abstract Introduction Acute kidney injury following Myocardial infarction is serious complication linked to higher mortality and prolonged hospital stay. This study investigates incidence and risk factors of acute kidney injury, focusing on how the timing of patients’ presentation after symptom…
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Journal Article
Mesangial sclerosing glomerulopathy following luspatercept treatment – a case report
Abstract Luspatercept is a recombinant fusion protein that enhances late-stage erythropoiesis by inhibiting select transforming growth factor β (TGFβ) superfamily ligands. It is approved for transfusion-dependent β-thalassemia and myelodysplastic syndromes with ring sideroblasts. Kidney toxicity…
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Journal Article
Healthy eating index and kidney function in adults: findings from the Ravansar non-communicable disease cohort
Abstract Background The global burden of chronic kidney disease (CKD) is increasing, driven largely by risk factors such as hypertension and diabetes. Modifiable lifestyle factors, particularly diet, may play a key role in renal health. This study aimed to investigate the association between diet…
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Journal Article
Symptom network structure across stigma subgroups in maintenance hemodialysis: a latent profile and network analysis
Abstract Background Maintenance hemodialysis (MHD) patients commonly experience stigma during long-term treatment, yet the characteristics of their subgroups and the associated patterns with symptom burden remain unclear. This study aimed to identify latent subgroups of stigma among MHD patients…
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