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BMC Biotechnology
Scopus
ISSN 1472-6750 · BMC · 1.631 artikel di indeks
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Artikel Jurnal
Impact of gamma irradiation on lemongrass (Cymbopogon citratus): phytochemical content, antioxidant and antibacterial activity
Abstract Background Gamma (γ) irradiation is a safe, non-chemical treatment used to decontaminate and enhance the biochemical quality of aromatic and medicinal plants. Cymbopogon citratus (lemongrass) essential oil (CCEO) is dominated by oxygenated monoterpenes such as citral and geraniol…
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Artikel Jurnal
Untargeted GC–MS metabolic profiling of Eurotium chevalieri AUMC 16390 (PX498623) reveals a putative steroidal metabolite with antibacterial and anti-inflammatory potential
Abstract Background This study investigated the exometabolome bioactive metabolites produced by Eurotium chevalieri AUMC 16,390 (accession number PX498623), a strain identified through ITS rDNA sequencing with 100% identity. The aim was to characterize its chemical profile and evaluate the…
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Artikel Jurnal
Statistical optimization of fermentation conditions for enhanced production of Nattokinase from Bacillus subtilis MM26
Abstract Background Nattokinase, a potent fibrinolytic serine protease enzyme has drawn significant industrial attention due to its remarkable thrombolytic activity. It is a natural alternative to conventional anticoagulant drugs because of its ability to disintegrate fibrin clots. Conventional…
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Artikel Jurnal
Rutin-luteolin flavonoid-encapsulated chitosan nanoparticles: a novel strategy to combat multidrug-resistant Pseudomonas aeruginosa
Abstract Pseudomonas aeruginosa (P. aeruginosa) is a major opportunistic pathogen with strong biofilm-forming ability and high resistance to antibiotics. Natural flavonoids such as rutin and luteolin possess antimicrobial potential, but their poor solubility and bioavailability limit therapeutic…
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Artikel Jurnal
Molecular cloning and characterization of a GH10 thermophilic xylanase from hot spring and its potential application in promoting probiotic growth
Abstract Background Xylan is widely found in plant cell walls, and xylanase, an essential enzyme in xylan breakdown, has promising applications in energy, food, feed, and healthcare sectors. Results This study presents the discovery of a novel GH10 family xylanase gene, termed Lc-Xyn81, isolated…
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Artikel Jurnal
Process parameters optimization of sweet orange juice ohmic heat-assisted vacuum evaporation and assessment of concentrate quality
Abstract Using an ohmic heat-assisted vacuum evaporation (OHVE) system, the process of concentrating clarified sweet orange fruit juice was carried out, and it was compared to a rotary vacuum evaporation (VE) method. Aim of the study was to maximize the total soluble solids (TSS) content in…
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Artikel Jurnal
Scaling the manufacture of adipose tissue-derived mesenchymal stromal cells: integrated bioreactor workflows from inoculation to harvest without the need of seed train
Abstract Background The production of human mesenchymal stromal cells (hMSC) for therapeutic use requires scalable, efficient and standardized manufacturing processes that could further benefit from shortening manufacturing time, automate and simplify operations with closed systems. This study…
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Artikel Jurnal
Construction and application of an insertional activation cloning vector
Abstract Background Foreign DNA cloning is a critical step in genetic engineering and molecular biology for acquiring target genes. Efficient and accurate identification of positive clones from transformants is essential to this process. Results Here, we engineered an insertion-activated cloning…
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Artikel Jurnal
Characterization of broad-host-range Salmonella phage GSP006 and its efficacy in controlling Salmonella Pullorum contamination in poultry feed and drinking water
Abstract Background Salmonella enterica subsp. enterica serovar Pullorum (Salmonella Pullorum) is the major pathogen that is harmful to the poultry industry in developing countries. It causes acute systemic and severe gastrointestinal diseases in chicks, resulting in high mortality. As a natural…
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Artikel Jurnal
Microalgal extracts optimize lettuce quality through extraction-method-dependent modulation of primary and secondary metabolism
Abstract Background Microalgal extracts are rich in bioactive molecules capable of modulating crop quality and stress resilience. This study investigated the effects of crude and formulated extracts based on three extraction methods—acidic, alkaline, and enzymatic—from Nannochloropsis gaditana and…
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Artikel Jurnal
Biosystematics and molecular characterization of three biotypes of Convolvulus arvensis L. (convolvolaceae) in Marsa Matrouh, Egypt
Abstract The notable characteristic of phenoplasticity in Convolvulus species is flower color polymorphism, with blooms ranging from white to pink. This variation is due to various factors, including genetic drift and natural selection. The primary objective is to conduct a study on the…
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Artikel Jurnal
Integrative analysis identifies the intratumoral Fusobacterium nucleatum as a driver of cervical cancer malignancy
Abstract Background Fusobacterium nucleatum (F. nucleatum) is an oral commensal bacterium that acts as a pathobiont with pro-tumorigenic activity in various gastrointestinal cancers. However, its functional role, invasive capacity, and mechanistic contributions in cervical cancer remain largely…
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Artikel Jurnal
Computer-guided enzyme engineering of PET hydrolase mutants towards improved PET affinity
Abstract Polyethylene Terephthalate (PET) is an extensively used plastic whose durability and resistance to degradation contribute to growing environmental pollution and concerns. Enzymatic PET degradation, particularly via PETase from Ideonella sakaiensis, has emerged as a sustainable approach due…
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Artikel Jurnal
Production and partial characterization of fructose-rich exopolysaccharide from a newly isolated halophilic strain Vreelandella sp. DT-Z4
Abstract Exopolysaccharide (EPS) synthesis of halophilic microorganisms is often reported as an adaptation to high-salt environments, and the unique structural and functional characteristics of these EPSs make them valuable biomaterials with promising application potential. A moderately halophilic…
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Artikel Jurnal
Yeast surface display-based screening and preliminary characterization of nectin-4-targeting nanobodies for bladder cancer
Abstract Background Advanced bladder cancer (BCa) is associated with a poor prognosis, highlighting the urgent need for novel therapeutic strategies with improved efficacy and reduced toxicity. Nectin-4 (PVRL4, here after referred to as N4) is a clinically validated therapeutic target; however…
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Artikel Jurnal
Metabolic profiling and systems biology analysis of Flammulina filiformis Fv19 extract: an integrated computational and experimental approach for dual anti-cancer and immunomodulatory therapy
Abstract Background The increasing demand for multi-target cancer therapies has prompted investigation into the anticancer and immunomodulatory potential of the hot water extract of Flammulina filiformis Fv19, utilizing in vitro cytotoxicity assays, in vivo murine models, and molecular docking…
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Artikel Jurnal
Antibacterial and antibiofilm activities of curcumin-mediated green-synthesised silver nanoparticles against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa
Abstract Background The rise in nosocomial infections caused by multidrug-resistant bacteria and the ability of bacteria to form biofilms have necessitated the exploration of alternative antimicrobial strategies. In this study, silver nanoparticles (AgNPs) were synthesised using a green method in…
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Artikel Jurnal
Multi-omic characterization of a soil microbial consortium reveals critical role of succinate and glutamate metabolism during calcium carbonate precipitation
Abstract Microbially induced calcium carbonate precipitation (MICP) holds potential for soil stabilization and carbon sequestration efforts, with the overall efficiency of the process being a major determinant for its use in many environmental and civil engineering applications. While the…
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Artikel Jurnal
Comparative analysis of horsetail and lavender-derived nanovesicles in wound healing and antioxidant defense
Abstract Background Plant-derived exosome-like nanovesicles (pEVs) have emerged as promising natural biomaterials due to their safety profile, high biocompatibility, and rich bioactive cargo. In particular, pEVs have attracted interest because of their roles in intercellular communication. This…
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Artikel Jurnal
Propolis-functionalized acellular fish skin scaffolds as biotechnological platforms for antimicrobial activity and regenerative wound healing
Abstract Background Biotechnological advances in tissue engineering increasingly exploit naturally derived scaffolds as bioactive delivery systems. Acellular fish skin (AFS) provides a collagen-rich extracellular matrix favorable for tissue regeneration but lacks intrinsic antimicrobial activity…
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