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Nature Reviews Drug Discovery
Scopus
ISSN 1474-1776 · Nature Portfolio · 73 artikel di indeks
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Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
Poor medication adherence is a pervasive issue with considerable health and socioeconomic consequences. Although the underlying reasons are generally understood, traditional intervention strategies rooted in patient-centric education and empowerment have proved to be prohibitively complex and/or…
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Applications of single-cell RNA sequencing in drug discovery and development
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data resources, are transforming drug discovery and development. New opportunities are emerging in target identification owing…
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Therapeutic strategies for COVID-19: progress and lessons learned
The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic strategies that target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and/or human proteins to control viral infection, encompassing hundreds of potential drugs and thousands of…
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
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The evolving role of investigative toxicology in the pharmaceutical industry
For decades, preclinical toxicology was essentially a descriptive discipline in which treatment-related effects were carefully reported and used as a basis to calculate safety margins for drug candidates. In recent years, however, technological advances have increasingly enabled researchers to gain…
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Targeting galectin-driven regulatory circuits in cancer and fibrosis
Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a broad range of physiological and pathological processes. As a group, these proteins use both extracellular and intracellular mechanisms as well as glycan-dependent and independent pathways to reprogramme the…
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Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation
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Function and therapeutic value of astrocytes in neurological diseases
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The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics