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Cardiovascular Diabetology
Scopus
ISSN 1475-2840 · BMC · 3.397 artikel di indeks
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Artikel Jurnal
The predictive value of C-reactive protein-triglycerides-glucose index-waist-to-height ratio for stroke: a nationwide cohort study
Abstract Background Combining biomarkers and anthropometric indicators is a common way to improve predictive efficacy. Yet the effect of the C-reactive protein-triglycerides-glucose index (CTI) and its derivatives on stroke is unknown. This study aims to explore their association with stroke and…
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Artikel Jurnal
Association of cholesterol, high-density lipoprotein and glucose (CHG) index with mortality risk in metabolic dysfunction-associated steatotic liver disease (MASLD) adults: results from two prospective cohorts
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a health issue of increasing concern worldwide. The cholesterol-high density lipoprotein-glucose (CHG) index integrates key metabolic pathways, but its relationship with the prognosis of MASLD remains unclear…
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Artikel Jurnal
From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce
Abstract International guidelines define standards of care for type 2 diabetes (T2D), obesity, cardiovascular disease (CVD), metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD). Yet implementation at the national level remains inconsistent, leading to…
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Artikel Jurnal
Predictive value of an integrated insulin resistance and lipometabolic score for cardiometabolic multimorbidity in older adults: a UK cohort study
Abstract Background Markers of insulin resistance, such as the triglyceride-glucose (TyG) index and estimated glucose disposal rate (eGDR), have been extensively linked to cardiometabolic multimorbidity (CMM). However, the roles of lipid metabolism indicators, including the atherogenic index of…
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Artikel Jurnal
A 5-hydroxymethylcytosine-based noninvasive model for acute myocardial infarction in type 2 diabetes: implications in cardiovascular outcomes from a 5-year median follow-up study
Abstract Background Patients with type 2 diabetes (T2D) are at an increased risk of developing acute myocardial infarction (AMI), yet the role of 5-hydroxymethylcytosines (5hmC) changes in T2D-associated cardiovascular events remains poorly understood. Despite therapeutic advances, patients with…
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Artikel Jurnal
Comparative effects of second-line oral antidiabetic medications on atrial fibrillation risk in patients with type 2 diabetes: a nationwide retrospective cohort study
Abstract Backgrounds Despite numerous studies investigating the effects of antidiabetic medications on cardiovascular outcomes, the optimal second-line oral antidiabetic medication for atrial fibrillation (AF) prevention remains unclear. This study aims to compare the effects of second-line oral…
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Artikel Jurnal
Association of atherogenic index of plasma and cardiometabolic index with all-cause mortality and cardiovascular disease in NAFLD patients: NHANES 1999–2018
Abstract Background The atherogenic index of plasma (AIP) serves as a crucial indicator for assessing atherosclerotic risk. It reflects the degree of dyslipidaemia and cardiovascular disease (CVD) risk. The cardiometabolic index (CMI) provides a comprehensive evaluation of obesity-related metabolic…
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Artikel Jurnal
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease
Abstract Background Mitochondrial dysfunction is a hallmark of diabetic kidney disease (DKD), yet its regulatory mechanisms remain poorly defined. Mitochondrial transcription factor A (TFAM), a central regulator of mitochondrial homeostasis, undergoes lysine 76 (K76) acetylation, but the functional…
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Artikel Jurnal
Sex‑specific cardiovascular risk in estrogen‑treated androgen‑deprived males: metabolic characterization of glucose, adipose, and lipid pathways
Abstract Background Estrogen therapy and androgen‑deprivation were once combined to treat prostate cancer (PrCa). Clinical studies later showed that prolonged estrogen exposure in androgen‑deprived men raises cardiovascular disease (CVD) risk, yet the metabolic pathways responsible remain unclear…
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Artikel Jurnal
Association of various insulin resistance surrogate indices with aging acceleration and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: insights from CHARLS 2011–2020 data
Abstract Background Cardiovascular-kidney-metabolic (CKM) syndrome imposes a substantial global health burden, with most adults clustered in early stages 0–3. Insulin resistance (IR), as a core manifestation of metabolic dysfunction, is thought to play a pivotal role in CKM progression and…
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Artikel Jurnal
Clinical subgroup-stratified plasma proteomic signatures improve risk prediction for myocardial infarction: SCORE2-Pro
Abstract Background Myocardial infarction (MI) remains a leading cause of global mortality, with risk varying substantially across demographic and clinical subgroups. Although SCORE2 is widely implemented for cardiovascular risk stratification, the extent to which clinical subgroup specific plasma…
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Artikel Jurnal
Association of the triglyceride glucose-Chinese visceral adiposity index with incident cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study
Abstract Objective Cardiometabolic multimorbidity (CMM) is a growing global health challenge. Whether the baseline or cumulative triglyceride glucose and Chinese visceral adiposity index product (TyG-CVAI) can predict incident CMM remains unclear. Methods We constructed two prospective cohorts from…
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Artikel Jurnal
Association of the C-reactive protein–triglyceride–glucose index with metabolic dysfunction-associated steatotic liver disease and long-term all-cause and cardiovascular mortality: evidence from two nationwide prospective cohort studies
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to cardiometabolic disorders, and cardiovascular disease is the leading cause of death among affected individuals. Identifying simple biomarkers that capture metabolic–inflammatory burden and…
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Artikel Jurnal
Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus
Abstract Background Type 2 diabetes mellitus (T2DM) predisposes patients to adverse cardiac remodeling even before the development of cardiomyopathic symptoms. The mechanisms for such early perturbations remain elusive. Given that myosin is the most abundant and energy‑demanding cardiac protein, we…
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Artikel Jurnal
Relationship between nine triglyceride-glucose-related indices and cardiometabolic multimorbidity incidence in patients with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study
Abstract Background Cardiovascular-kidney-metabolic (CKM) syndrome integrates metabolic, renal, and cardiovascular disease risk. While increasing evidence suggests that triglyceride-glucose (TyG)-related indices are associated with the future risk of cardiometabolic multimorbidity (CMM), their link…
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Artikel Jurnal
Echocardiography and inflammatory biomarkers for predicting mortality and major adverse cardiovascular events in type 1 diabetes
Abstract Background/aims Current clinical risk tools in type 1 diabetes do not include left ventricular dysfunction or inflammation, potentially limiting early risk detection. We aimed to evaluate the associations and predictive value of combining echocardiography with inflammatory biomarkers for…
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Artikel Jurnal
Impacts of ketogenic diet intervention on cardiometabolic outcomes in obese, dysglycemic mice
Abstract Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diabetes is often comorbid with liver steatosis and atherosclerosis which are characterized by…
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Artikel Jurnal
Joint assessment of insulin resistance surrogate indices and basal metabolic rate for primary prevention of cardiometabolic multimorbidity: evidence from the China Health and Retirement Longitudinal Study (2011–2020)
Abstract Background The triglyceride-glucose (TyG) index, estimated glucose disposal rate (eGDR), and metabolic score for insulin resistance (METS-IR) are well-established surrogate indices of insulin resistance (IR). Although both IR and elevated basal metabolic rate (BMR) are recognized risk…
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