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Cancer Cell International
Scopus
ISSN 1475-2867 · BMC · 4.316 artikel di indeks
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Artikel Jurnal
Sirt6 promotes tumor growth and suppresses immune surveillance
Abstract Background Many studies have reported increased Sirt6 expression and activity in many tumor tissues, and the expression level is inversely linked to overall patient survival. This study explored how Sirt6 affects tumor growth and immune surveillance. Methods UBCS039, a selective Sirt6…
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Artikel Jurnal
Integrating machine learning and multi-omics analysis to explore Treg-associated programmed cell death features in clear cell renal cell carcinoma
Abstract Background Treg infiltration and programmed cell death are important factors influencing cancer progression, and they interact with each other. However, the significance of Treg-related programmed cell death (PCD) characteristics in clear cell renal cell carcinoma remains unclear. Methods…
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Artikel Jurnal
Serum N-glycan NA3Fb identified as a prognostic biomarker of poor outcome in HBV-related hepatocellular carcinoma
Abstract Background Glycosylation, as one of the most prevalent forms of post-translational modification, plays a pivotal role in tumor progression through structural alterations of serum N-glycans in hepatocellular carcinoma (HCC). In this study, we systematically investigated these N-glycan…
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Artikel Jurnal
Unresolved questions on the GADD45GIP1–RPL35 axis in osteosarcoma: mechanistic links to ER stress and therapeutic targeting
Abstract In their recent study, Li et al. (2025) propose a novel signaling axis in which GADD45GIP1 promotes osteosarcoma progression by stabilizing RPL35, thereby alleviating endoplasmic reticulum (ER) stress through the PERK/eIF2α pathway. While this work identifies a potentially significant…
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Artikel Jurnal
Single-cell spatial analysis identifies ID1-high endothelial cells in tertiary lymphoid structures as predictors of durable response to immunotherapy in non-small cell lung cancer
Abstract Background Tertiary lymphoid structures (TLSs) maturity and cellular composition shape resistance or sensitivity to immune-checkpoint blockade (ICB) across cancers. Single-cell spatial resolution data for the endothelial compartment of TLSs are lacking; therefore, we investigated the…
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Artikel Jurnal
Molecular subtype-specific breast cancer organoids: development of an FGF-free estradiol valerate culture system for precision drug screening
Abstract Breast cancer, a prevalent malignancy among women, exhibits high heterogeneity, highlighting the critical need for personalized treatment strategies. Breast cancer organoids (BCOs), an emerging in vitro research tool, closely mimic the biological characteristics of tumors and demonstrate…
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Artikel Jurnal
VMP1 inhibits the progression of breast cancer via regulating PI3K/AKT and MEK/ERK signaling pathway
Abstract Background Vacuolar membrane protein 1 (VMP1) is an endoplasmic reticulum - resident and multi - spanning membrane protein involved in various human cancers. However, its biological functions and molecular mechanisms in breast cancer remain underexplored. Methods Gene expression profiling…
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Artikel Jurnal
Modeling primary immunotherapy resistance in metastatic bladder cancer: a syngeneic, bioluminescent mouse model
Abstract Approximately 90% of bladder cancer deaths are due to distant metastases rather than local tumor effects. The current first-line systemic treatment for metastatic bladder cancer (mBC) is chemoimmunotherapy or immunotherapy with pembrolizumab plus enfortumab vedotin (EV). However, most mBC…
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Artikel Jurnal
Rho-related GTP-binding protein RhoE (RND3) regulates multiple myeloma bone disease
Abstract Multiple Myeloma bone disease (MMBD) is highly prevalent in the multiple myeloma (MM) patients. Using the patients’ gene expression profile, we identified Rho Family GTPase 3 (RND3) as a gene whose expression in MM negatively associated with MMBD severity. Using MM patients’ biopsies, we…
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Artikel Jurnal
TMEM105 upregulation promotes colorectal cancer malignancy: a novel prognostic biomarker potentially linked to the MYC-Ribosome biogenesis axis
Abstract Transmembrane protein 105 (TMEM105 ) has recently emerged as a potential oncogenic factor in various malignancies, yet its role in colorectal cancer (CRC) remains unclear. In this study, we comprehensively investigated the expression and function of TMEM105 in CRC through an integrated in…
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Artikel Jurnal
Integrative exercise and nutrition strategies in leukemia survivorship: implications for cognitive function and quality of life
Abstract Leukemia survivorship presents ongoing clinical and functional challenges, including persistent fatigue, metabolic disturbances, and reduced quality of life. Integrative, non-pharmacologic strategies that combine exercise and targeted nutrition may help address these late effects. This…
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Artikel Jurnal
Circulating extracellular vesicle PTPRO methylation: an exploratory biomarker for minimally invasive diagnosis of early-stage lung adenocarcinoma
Abstract Protein tyrosine phosphatase receptor-type O (PTPRO), a member of the PTP family, has garnered attention for its diagnostic and prognostic potential through the methylation of circulating tumor DNA (ctDNA). However, the utility of ctDNA has shown limited sensitivity and specificity…
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Artikel Jurnal
Single-cell and machine learning approaches reveal METTL14-mediated autophagy via PI3K/AKT signaling in invasive PitNET
Abstract Objective This study investigates the role of m6A regulators in invasive pituitary neuroendocrine tumors (PitNETs) by defining m6A-related molecular subtypes, constructing a nomogram, and elucidating the mechanistic role of METTL14 in PitNET progression. Methods GEO datasets were analyzed…
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Artikel Jurnal
The NEAT1/miR-506-3p/STAT3 axis promotes uveal melanoma progression and represents a potential therapeutic target
Abstract Uveal melanoma (UM), a prevalent intraocular malignancy with a high rate of metastasis, particularly to the liver, presents a significant therapeutic challenge due to the absence of effective treatments. Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are under scrutiny for their…
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Artikel Jurnal
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway
Abstract Background Oral cancer (OC) is the most common type of head and neck cancer, with a high mortality rate, and is a leading cause of cancer-related deaths worldwide. Drug-induced ferroptosis is a novel form of non-apoptotic cell death that offers a promising strategy for cancer therapy…
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Artikel Jurnal
SLC25A39 facilitates Sorafenib resistance in hepatocellular carcinoma by inhibiting mitochondrial oxidative stress-induced ferroptosis
Abstract Mitochondria are intracellular double-membrane-bound organelles that play a crucial role in maintaining redox homeostasis, disruptions of which are closely linked to oncogenesis. Recent investigations have identified SLC25A39 as a mitochondrial membrane transporter essential for the…
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Artikel Jurnal
Comprehensive analysis of key palmitoylation-modifying enzymes in clear cell renal cell carcinoma: implications for prognosis and therapy
Abstract Background Palmitoylation, a key post-translational modification, plays a crucial role in tumor progression, yet its landscape in clear cell renal cell carcinoma (ccRCC) remains poorly characterized. This study aims to systematically identify and validate key palmitoylation-modifying…
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Artikel Jurnal
Low frequency and rare coding variants affect susceptibility and progression of childhood acute lymphoblastic leukemia
Abstract This study aimed to explore the potential genetic underpinnings of childhood acute lymphoblastic leukemia (ALL). Initially, an exome-wide association analysis of 89 ALL survivors and 356 controls was conducted to identify candidate genes, incorporating single-variant tests and…
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Artikel Jurnal
Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatment
Abstract Long non-coding RNAs (lncRNAs) are broad-spectrum cellular transcripts that can directly act as RNA regulators and/or partly encode functional peptides (lncRNA-encoded peptides, LRPs) in cancer cells. Recently, cancer LRPs have been found to be involved in cancer cell variability and…
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Artikel Jurnal
PARP1 trapping activates cGAS-STING pathway to induce immunogenic cell death in multiple myeloma
Abstract Background Alternative Non-Homologous End Joining (Alt-NHEJ) DNA repair is considered a major player in cancer genomic instability. Here, we investigated cGAS-STING pathway as crucial node in the interplay between Alt-NHEJ repair and immune response, in the aim to discover novel…
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