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Annals of Clinical Microbiology and Antimicrobials
Scopus
ISSN 1476-0711 · BMC · 956 articles in the index
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Journal Article
Genomic epidemiology and aztreonam–avibactam resistance mechanisms of Proteus mirabilis in china: an eight-year retrospective study
Abstract Background Proteus mirabilis has emerged as an important multidrug-resistant opportunistic pathogen, with the production of metallo-β-lactamases (MBLs) being a major contributor to its broad-spectrum resistance. Although the aztreonam-avibactam (ATM-AVI) combination represents a key…
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Journal Article
Peritonsillar abscess in children: age-stratified incidence rates, microbiology, and evaluation of penicillin as drug of choice
Abstract Introduction Peritonsillar abscess is the most frequent complication of acute tonsillitis. Although adult epidemiology and microbiology are well characterized, age-specific pediatric data remain limited. We investigated the incidence, microbiology, and suitability of penicillin monotherapy…
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Journal Article
Pathogen-specific IgE-reactive cytosolic allergenic epitopes of Aspergillus fumigatus for immunodiagnostic/immunotherapeutic applications against allergic aspergillosis
Highlights Aspergillosis: Global disease. Pathogen-specific allergen/epitope. Utility in diagnostics and therapeutics.
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Journal Article
Clinical impact of altered gut microbiota and metabolite profiles on mortality in patients with candidemia: a prospective observational pilot cohort study
Abstract Background The gut microbiota plays an important role in defending against infectious diseases. However, data on the clinical implications of the microbiome profiles in patients with candidemia remain limited. In this study, we investigated the association between the intestinal microbiome…
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Journal Article
Transient AdeABC-mediated eravacycline resistance in carbapenem-resistant Acinetobacter baumannii ST2: a mutation-independent efflux pump adaptation
Abstract Purpose This study evaluated the impact of sub-MIC eravacycline exposure on carbapenem-resistant Acinetobacter baumannii with tigecycline MIC ≥ 8 µg/mL in clinical laboratory testing, and analyzed the resistance mechanisms. Methods 2144 A. baumannii isolates (2021–2024) from a Chinese…
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Journal Article
The impact of the timing of mNGS-guided antibiotic adjustment on clinical outcomes in ICU patients with severe community-acquired pneumonia: a retrospective study
Abstract Background Severe community-acquired pneumonia (SCAP) remains a major cause of intensive care unit (ICU) admission and mortality. Prompt pathogen identification and timely administration of appropriate antimicrobial therapy are essential for improving patient outcomes. Although metagenomic…
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Journal Article
Fatal multi-drug-resistant gram-negative bacterial pneumonia among adults hospitalized àt Mulago National Referral Hospital, Uganda: an autopsy study
Abstract Background Pneumonia, responsible for three million deaths annually worldwide, remains a leading cause of death from hospital-acquired infections. Unfortunately, treatment in most cases is empirical and not based on microbiological data because of difficulty in obtaining reliable lower…
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Journal Article
Clinical patterns, species-specific correlations, and therapeutic outcomes of nocardiosis in immunocompetent individuals: a systematic analysis based on literature
Abstract Background Nocardiosis, traditionally an opportunistic infection, lacks comprehensive characterization in immunocompetent individuals. This study aimed to describe and analyze the demographics, clinical features, and outcomes of Nocardia infections in this population based on the…
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Journal Article
Coexistence with Staphylococcus aureus modulates the virulence and antibiotic resistance of Pseudomonas aeruginosa
Abstract Background In this study, we were aimed to investigate the impact of co-cultures of different bacterial species on bacterial antibiotic resistance and virulence. Methods The effect of co-cultures of Pseudomonas aeruginosa (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive…
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Journal Article
Clinical features of nontuberculous mycobacteria and diagnosis with nanopore targeted sequencing: a retrospective cohort study
Abstract Background Diagnosing pulmonary non-tuberculous mycobacterial (NTM) disease remains challenging, not only because its clinical manifestations often overlap with those of tuberculosis (TB), but also because its symptoms and signs—such as chronic cough, sputum production, fatigue, and weight…
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Journal Article
Clinical characteristics and temporal trends of meropenem and piperacillin/tazobactam heteroresistance in Pseudomonas aeruginosa isolates
Abstract Background Heteroresistance (HR) to commonly used anti-pseudomonal agents in Pseudomonas aeruginosa has been reported in cross-sectional epidemiological surveys; however, longitudinal studies investigating the long-term epidemiological dynamics and clinical correlates of this adaptive…
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Journal Article
Convergent evolution of ST2 and ST164 mediates dissemination of the bla NDM-1/bla OXA-23 profile in Acinetobacter baumannii
Abstract Background The convergence of the potent carbapenemase genes bla NDM-1 and bla OXA-23 in carbapenem-resistant Acinetobacter baumannii (CRAB) poses a critical threat. However, the dissemination patterns and evolutionary drivers of this dual-carbapenemase profile remain unclear. Methods We…
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Journal Article
Investigation of atypical microbial agents in patients with sterile pyuria
Abstract Background To determine the frequency of microbial DNA detection in patients with sterile pyuria and evaluate the association of leukocyte count and leukocyte esterase (LE) test results with physicians’ treatment decisions. Methods This prospective cross-sectional study was conducted over…
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Journal Article
Gut microbiome features associated with vancomycin-resistant Enterococcus acquisition in intensive care unit patients
Abstract Background Vancomycin-resistant Enterococcus (VRE) infection poses a significant healthcare burden in intensive care units (ICUs), and is preceded by gut colonization. The gut microbiome may influence susceptibility to VRE, but its role in ICU patients remains incompletely defined. Methods…
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Journal Article
A nomogram for assessing secondary infection risk in hospitalized patients with intestinal CRE colonization: a prospective cohort study
Abstract Objective To investigate the epidemiology, risk factors, and molecular characteristics of intestinal carbapenem-resistant Enterobacterales (CRE) colonization and subsequent secondary infections in a hospital setting, and to develop a predictive model for risk stratification. Methods A…
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Journal Article
Comparative evaluation of tigecycline susceptibility testing methods for carbapenem-resistant Klebsiella pneumoniae and Acinetobacter baumannii
Abstract Background In this study, we aimed to evaluate the performance of different tigecycline susceptibility testing methods for CRKP and CRAB using the broth microdilution (BMD) method as the gold standard, under different breakpoint criteria. Methods A total of 53 CRKP and 47 CRAB clinical…
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Journal Article
Associations of Mycoplasma pneumoniae load, co-infections, and macrolide resistance with clinical-laboratory profiles in hospitalized pediatric pneumonia: a targeted next-generation sequencing study of bronchoalveolar lavage fluid
Abstract Purpose This study aimed to evaluate the associations of Mycoplasma pneumoniae (MP) DNA load, co-infection, and macrolide resistance with clinical phenotypes in pediatric pneumonia, using targeted next-generation sequencing (tNGS) of bronchoalveolar lavage fluid (BALF). Methods We…
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Journal Article
Within-host mechanisms of resistance evolution in polymyxin B-resistant Klebsiella pneumoniae without prior exposure
Abstract Background Polymyxin B-resistant Klebsiella pneumoniae (PBR-KP) has been emerging as a significant concern. This study investigated the within-host mechanisms of resistance evolution in PBR-KP without prior PB exposure. Methods Six groups were enrolled [PB-sensitive K. pneumoniae (PBS-KP)…
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Journal Article
Temporal dynamics of serum Mycoplasma pneumoniae antibodies in patients with acute respiratory infections: a large retrospective study
Abstract Objective Mycoplasma pneumoniae (MP) has re-emerged with a surging incidence in China following the lifting of COVID-19 non-pharmaceutical interventions, posing a critical challenge for clinical diagnosis and management of acute respiratory infections (ARI). We aimed to investigate the…
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Journal Article
Metagenomic-based quantification of Pseudomonas aeruginosa burden links microbiome collapse to mortality in severe community-acquired pneumonia
Abstract Background Severe community-acquired pneumonia (sCAP) remains a major cause of mortality in critically ill patients, Pseudomonas aeruginosa (P. aeruginosa) is a frequent pathogen associated with poor prognosis in this population. While metagenomic next-generation sequencing (mNGS) is…