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Lipids in Health and Disease
Scopus
ISSN 1476-511X · BMC · 3.374 artikel di indeks
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Artikel Jurnal
Dyslipidemia is associated with abdominal fat depots but not with bone mineral density and muscle fat infiltration
Abstract Background Dyslipidemia (DLP) is linked to adverse abdominal fat distribution; however, its relationship with bone mineral density (BMD) and muscle fat infiltration (MFI) remains unclear. This study aimed to assess, using quantitative computed tomography (QCT), whether DLP is associated…
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Artikel Jurnal
Remnant cholesterol and lipid ratios predict the relapse of neuromyelitis optica spectrum disorder
Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is a demyelinating condition in the central nervous system whose relapses cause severe disability progression. Although conventional blood lipid markers are linked to disease course and outcomes, the predictive value of emerging…
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Artikel Jurnal
Combination therapy of statin and acipimox versus statin monotherapy in acute myocardial infarction with hypertriglyceridemia: a multicenter propensity score–matched analysis
Abstract Background Residual cardiovascular risk persists in patients with acute myocardial infarction (AMI) and hypertriglyceridaemia despite statin therapy. The potential benefit of acipimox, a niacin derivative, as an adjunct to statins in this context remains uncertain. This study evaluated the…
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Artikel Jurnal
Abnormal lipid profile in the context of liver steatosis measured by transient elastography: experiences from an outpatient endocrine clinic
Abstract Background Dyslipidaemia is a recognised risk factor for cardiovascular diseases which remain the leading cause of death worldwide. There is a knowledge gap whether the prevalence/pattern of dyslipidaemia depends on the aetiology of the liver disease. Objective To evaluate the association…
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Artikel Jurnal
Adipokine networks in diabetic kidney disease: mechanistic insights and therapeutic implications
Abstract Diabetic kidney disease (DKD), the predominant microvascular complication of diabetes mellitus, perpetuates a significant global health and socioeconomic challenge, complicating the pursuit of sustainable renal care. Adipokines, bioactive proteins secreted by adipose tissue that modulate…
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Artikel Jurnal
Alternative polyadenylation mediated the downregulation of lysophosphatidylglycerol acyltransferase 1 in metabolic dysfunction-associated steatotic liver disease
Abstract Background Alternative polyadenylation (APA) is a critical post-transcriptional regulatory mechanism involved in various diseases. Studies have shown dysfunction of APA-regulating factors such as SRSF10 in metabolic dysfunction-associated steatotic liver disease (MASLD). However, the…
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Artikel Jurnal
The mediating effect of triglycerides and related indices on the association between polycyclic aromatic hydrocarbons and oral health in adults aged ≥ 45 years from the national health and nutrition examination survey 2003–2016
Abstract Background Environmental pollutants are known determinants of oral health; however, the specific effects of polycyclic aromatic hydrocarbons (PAHs) on the oral health of adults aged ≥ 45 years remain poorly understood. This study investigated the association between PAH exposure and oral…
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Artikel Jurnal
Offspring BMI and lipid profiles following assisted reproductive technology: a comparative study of underweight and normal-weight mothers
Abstract Background The early developmental environment is associated with long-term metabolic health outcomes in children. A large proportion of underweight women tend to become pregnant via assisted reproductive technology (ART). However, the correlation between maternal prepregnancy underweight…
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Artikel Jurnal
Preoperative LDL-C and mortality after cardiac valve surgery: a retrospective cohort study on the mediating role of inflammatory risk
Abstract Background The connection between low-density lipoprotein cholesterol (LDL-C) levels and postoperative outcomes following cardiac valve surgery (CVS) remains controversial. Therefore, this research aimed to study the connection of LDL-C levels with the incidence of adverse clinical…
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Artikel Jurnal
Cumulative average remnant cholesterol inflammatory index and risk of cardiometabolic multimorbidity: evidence from a prospective nationwide cohort study in China
Abstract Background Cardiometabolic multimorbidity (CMM) poses a major health burden in aging populations. The long-term effect of cumulative remnant cholesterol inflammatory index (RCII) on CMM remains unclear. This study aimed to examine this relationship among middle-aged and older Chinese…
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Artikel Jurnal
A novel nutritional index and risk of edentulism: evidence from cross-sectional, prospective, and trajectory analyses
Abstract Background Nutritional status, recognized as a modifiable determinant of oral health, has recently gained increasing attention in the context of edentulism. The triglyceride–total cholesterol–body weight index (TCBI) is a novel nutritional indicator derived from routine clinical measures…
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Artikel Jurnal
Hypertriglyceridemia in chronic kidney disease: pathophysiological mechanisms, cardiovascular risk, and emerging therapeutics
Abstract Hypertriglyceridemia (HTG) is highly prevalent among patients with chronic kidney disease (CKD) and plays a critical role in both the progression of nephropathy and the increased risk of cardiovascular events. The underlying pathophysiology involves metabolic disturbances of triglyceride…
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Artikel Jurnal
Serum YB-1 links dyslipidemia to NET-mediated vascular calcification in hemodialysis
Abstract Background Vascular calcification (VC) is highly prevalent in patients undergoing maintenance hemodialysis (MHD) and is associated with cardiovascular morbidity. However, traditional lipid and mineral markers have limited predictive value. Y-box binding protein-1 (YB-1), a regulator of…
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Artikel Jurnal
Changes in local lipids are correlated with bone microarchitecture alterations during aging and ovariectomy-induced osteoporosis in rat femur: focus on the Δ9-desaturase 18:1/18:0 index and arachidonic acid level
Abstract Background In both aging and osteoporosis conditions, bone loss was positively correlated to bone marrow adiposity; however, the associated lipid signature remains to be clarified. This study aims to explore local lipid variations in relation to bone alteration during aging and after…
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Artikel Jurnal
Association of apolipoprotein B and excess apolipoprotein B with cardiovascular risk in type 2 diabetes: a prospective cohort study of the UK Biobank
Abstract Background Residual cardiovascular risk persists in type 2 diabetes mellitus (T2DM) despite intensive risk-factor management. Apolipoprotein B (apoB) and excess apoB are potentially promising biomarkers for identifying residual cardiovascular risk. We assessed apoB and excess apoB in T2DM…
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Artikel Jurnal
Associations of metabolic indicators and inflammation-related indices with adverse cardiovascular events in US adults: NHANES 1999–2018
Abstract Background Processes in cardiovascular disease (CVD) are associated with metabolic perturbations and inflammation. The mediating role of inflammation in connecting metabolic factors to adverse cardiovascular outcomes and the joint effects of both factors on CVD and mortality are poorly…
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Artikel Jurnal
High-Density Lipoproteins (HDLs) contribute to limiting acute tissue damage: proof of concept in a model of mercury-induced nephrotoxicity
Abstract Background Previous studies suggest that HDLs may protect against the effects of acute injury. Given their multiple beneficial properties, this study aimed to investigate whether exogenous HDLs administration reduces acute tissue damage in a HgCl2-induced renal injury model, potentially…
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Artikel Jurnal
Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study
Abstract Background Inflammation and metabolic disorders significantly contribute to frailty development. The C-reactive protein-triglyceride-glucose index (CTI) indicates both inflammation and insulin resistance (IR). This study delves into the connection between various dimensions of CTI—baseline…
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Artikel Jurnal
Insights into the complex relationship between body roundness index, atherogenic index of plasma, and stroke: a nationwide prospective cohort study
Abstract Background and objective Both body roundness index (BRI) and atherogenic index of plasma (AIP) are risk factors for stroke. This study seeks to ascertain whether AIP mediates the relationship between BRI and stroke risk, as well as to investigate their interaction, combined effects, and…
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Artikel Jurnal
Rethinking the lipid paradox: the role of baseline characteristics in LDL-C and long-term mortality after acute myocardial infarction
Abstract Background Previous observations have reported inconsistent results on the association between low-density lipoprotein cholesterol (LDL-C) at presentation and long-term outcomes after acute myocardial infarction (AMI). We aimed to clarify the potential impact of baseline characteristics on…
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