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Journal of Nanobiotechnology
Scopus
ISSN 1477-3155 · BMC · 4.756 artikel di indeks
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Artikel Jurnal
HIFU postoperative hypoxia-activated metal-organic frameworks modulate the tumor microenvironment to augment immunotherapy
Abstract Limited intensity and duration of high-intensity focused ultrasound (HIFU)-induced immune response largely hinder postoperative immunotherapy due to low immunogenicity and immunosuppression of tumor microenvironment (TME). In this study, effect-specific metal-organic frameworks (MOFs) were…
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Artikel Jurnal
f-SPION-mediated magnetic stimulation induces reparative Schwann cell reprogramming via cytoskeletal dynamics - gated activation of Piezo1
Abstract Background The remarkable intrinsic regenerative capacity of peripheral nerves following injury is largely attributed to the phenotypic plasticity of Schwann cells (SCs) and their ability to transition into a repair-supportive state (rSCs). Transcriptional reprogramming of SCs into this…
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Artikel Jurnal
Artemisia-derived carbon dots with excellent pharmacological activities and ROS scavenging for osteoarthritis treatment
Abstract The pharmacological activities of traditional herbal medicine-derived carbon dots (THM-CDs) render them highly promising for applications in biomedicine. However, the interactions between THM-CDs and intracellular proteins have yet to be fully elucidated. Herein, inspired by the…
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Artikel Jurnal
Dual-responsive zwitterionic hydrogel microneedle patch for the on-site detection of two alzheimer’s disease - related miRNAs
Abstract Nowadays, specific biomarkers and detection methods for the early, rapid and non-invasive diagnosis of Alzheimer’s disease (AD) are scarce. MiR-34a and miR-206 are both upregulated in the cerebrospinal fluid and peripheral fluids of AD patients. In view of the similar biochemical…
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Artikel Jurnal
Self-assembled nanonetworks of highly stable gemini surfactant-like peptides: antibacterial mechanisms, self-assembly characteristics, and in vivo anti-infection potential
Abstract The escalating prevalence of bacterial resistance underscores the critical demand for developing non-antibiotic therapeutic candidates. Antimicrobial peptides (AMPs) with potent efficacy and low toxicity have emerged as a promising alternative strategy; however, their suboptimal…
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Artikel Jurnal
Sorafenib nanomedicine in HCC: nano-bio interactions and combination therapies
Abstract Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with systemic therapies offering only limited benefit. Sorafenib, the first-line multi-kinase inhibitor, is constrained by poor pharmacokinetics, dose-limiting toxicities, and the rapid emergence…
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Artikel Jurnal
Clusterzymes-driven therapy: ultrasmall Cu4 nanoclusters achieve dual-pronged synergistic effects on antioxidant defense and ferroptosis Inhibition for inflammatory osteolysis
Abstract Inflammatory osteolysis represents a critical complication following orthopedic interventions such as total joint replacement, primarily triggered by persistent inflammatory responses induced by prosthetic wear debris or bacterial components like lipopolysaccharides (LPS). Inflammatory…
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Artikel Jurnal
Biomimetic nanovesicles decorated with chemotactic and target membrane proteins for lupus nephritis treatment
Abstract Cell membrane-coated drug delivery systems show advantages of immune escape and bio-mimicking targeting capacity; attention in this area is focusing on further enhancing their targetability for specific cells to improve delivery efficacy and therapeutic effectiveness. Here, we report a…
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Artikel Jurnal
A dual-action core-shell microneedle system restores mitochondrial function and accelerates healing in diabetic wounds
Abstract Diabetic wounds remain a significant clinical challenge due to persistent oxidative stress, chronic inflammation, and vascular dysfunction. Leveraging single-cell RNA sequencing, we identified voltage-dependent anion channel 1 (VDAC1) as a key endothelium target upregulated twofold in…
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Artikel Jurnal
Zn2+-mediated siRNA-doxorubicin self-assembled nanoparticles amplify Immunogenic cell death via aggravating redox dyshomeostasis for cancer therapy
Abstract Immunogenic cell death (ICD), instigated by reactive oxygen species (ROS), has emerged as an efficacious strategy for augmenting the immunogenicity of tumor cells. However, the effects of ICD are severely diminished by elevated levels of glutathione (GSH) within tumor cells to maintaining…
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Artikel Jurnal
Cerium-doped prussian blue nanozymes for bone regeneration and osteoprotection by Lhx2 in sutural distraction osteogenesis through multi-omics analysis
Abstract Sutural distraction osteogenesis (SDO) involves the induction of new bone formation in the suture region through external distraction, widely employed for treating craniomaxillofacial deformities such as craniosynostosis and maxillary transverse hypoplasia. Nonetheless, there remains a…
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Artikel Jurnal
Multimodal electroconductive PLGA-based scaffold orchestrates neuroprotection and regeneration following severe spinal cord injury
Abstract Spinal cord injury (SCI) is a devastating neurological condition that has limited therapeutic options; thus, developing innovative regenerative strategies to treat SCI is necessary. This study presents a multifunctional scaffold system that synergistically combines poly(lactic-co-glycolic…
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Artikel Jurnal
Pathology-tailored nanotherapy via Galectin-3-targeted and triple-responsive nanoparticles enables multimodal therapy against aortic dissection
Abstract Aortic dissection (AD) is a life‑threatening vascular disorder with high mortality and no effective pharmacological treatment. Addressing its multicellular and dynamic pathology requires strategies that precisely modulate inflammatory and degenerative processes, yet existing targeted…
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Artikel Jurnal
Engineering bacteriophages for gut health: precision antimicrobials and beyond
Abstract Engineered bacteriophages are emerging as a promising class of precision antimicrobials at a time when gastrointestinal diseases are increasingly linked to microbial dysbiosis, antibiotic resistance, and disruptions in host–microbe interactions. Conventional antibiotics often provide…
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Artikel Jurnal
Injectable multi-component hydrogels for the treatment of ascites caused by hepatocellular carcinoma via anti-tumor and reduction of ascites generation
Abstract Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide, and malignant ascites (MA) caused by HCC is almost incurable. However, the efficacy of chemotherapy is limited by poor tumor drug targeting and the presence of an immunosuppressive…
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