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World Journal of Surgical Oncology
Scopus
ISSN 1477-7819 · BMC · 4.544 artikel di indeks
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Artikel Jurnal
LncRNA FRMD6-AS2 inhibits the malignant progression of bladder cancer by targeting miR-1260a
Abstract Background Bladder cancer (BC) ranks as the most prevalent malignant neoplasm affecting the urinary system. However, its clinical prevention and treatment continue to face significant challenges. This research aims to investigate the biological roles and regulatory mechanisms of FRMD6-AS2…
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Artikel Jurnal
Impact of interaction between interleukin-27 gene polymorphisms and smoking with susceptibility to non-small cell lung cancer in Chinese Han population
Abstract Objectives The aim of this study was to investigate the impact of interleukin-27 (IL- 27) gene polymorphism and additional interactions with environmental factors on non-small cell lung cancer (NSCLC) risk based on a Chinese population. Methods SNPStats online software (…
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Artikel Jurnal
The association of survival with adjuvant chemotherapy in patients with ypTNM stage I gastric cancer after neoadjuvant chemotherapy
Abstract Background Neoadjuvant chemotherapy (NAC) combined with gastrectomy has been a standard therapeutic strategy for resectable gastric cancer (GC). However, it remains unclear whether postoperative adjuvant chemotherapy (AC) brings better survival in ypTNM stage I GC patients. Methods Data on…
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Artikel Jurnal
Extent of lymphadenectomy in thoracic esophageal squamous cell carcinoma: a meta-analysis of three-field versus two-field dissection
Abstract Background The comparative oncologic and perioperative benefits of three-field versus two-field lymphadenectomy in thoracic esophageal squamous cell carcinoma (ESCC) remain debated. This systematic review and meta-analysis evaluated outcomes across survival, nodal clearance, surgical…
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Artikel Jurnal
Underutilization of CRS, HIPEC & PIPAC in peritoneal mesothelioma across a German nationwide cohort
Abstract This retrospective cohort study utilizes a nationwide database to provide information about the epidemiology and surgical treatment practices of peritoneal mesothelioma in Germany over the years 2019 to 2024. Data collected by the German Institute for the Hospital Remuneration System…
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Artikel Jurnal
Survival prognosis and influencing factors in elderly patients with stage I-III breast cancer
Abstract Aims To analyse the survival prognosis of elderly patients with stage I-III breast cancer and to explore the related clinicopathological influencing factors. Methods Retrospective collection of clinicopathological data from elderly breast cancer patients (aged ≥ 65 years) admitted to…
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Artikel Jurnal
Perioperative management of non-metastatic gastroesophageal cancer in a Philippine university hospital: a 10-year experience
Abstract Background Gastroesophageal junction (GEJ) cancer has remained a significant global health challenge due to late-stage diagnosis and poor survival outcomes. This study presents the 10-year institutional experience in the multimodal management of non-metastatic GEJ cancer in a low-resource…
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Artikel Jurnal
miR-19a-3p accelerates the development of melanoma and reduces the prognosis of patients
Abstract Background Previous studies have shown that miR-19a-3p is expressed at higher levels in melanoma tissues, suggesting that it may be involved in the progression of melanoma. This study sought to elucidate the biological function of miR-19a-3p in melanoma. Methods In this study, RT-qPCR was…
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Artikel Jurnal
ERBB2 I655V mutation correlates with efficacy of immunotherapy in gallbladder cancer
Abstract Background Gallbladder cancer (GBC) is a highly aggressive malignancy of the digestive system with a poor prognosis. Therefore, the development of effective targeted therapeutic strategies is critical for improving survival outcomes in patients with GBC. Erb-B2 receptor tyrosine kinase 2…
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Artikel Jurnal
Diagnostic accuracy and surgical outcomes of fluorescence-guided surgery in breast cancer: a systematic review and meta-analysis
Abstract Background Intraoperative evaluation of breast surgical margins is essential for reducing re-excision rates in lumpectomy patients. Fluorescence-guided surgery (FGS) has emerged as a promising technique to enhance intraoperative detection of cancer and optimize surgical outcomes. We…
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Artikel Jurnal
Hemicorporectomy: a case report on a last-resort surgical procedure
Abstract Background Hemicorporectomy is an exceptionally rare and radical procedure reserved for highly selected patients with locally advanced pelvic malignancies without distant metastasis. Dedifferentiated sacral chordoma represents an aggressive histological subtype that may preclude…
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Artikel Jurnal
Psychological crisis in patients with primary liver cancer after transarterial chemoembolization: epidemiological characteristics and associated factors
Abstract Background Transarterial chemoembolization (TACE) remains a widely embraced therapeutic modality for primary liver cancer. The present study sought to explore the prevalence of psychological crisis in patients with primary liver cancer following TACE and pinpoint its associated factors, to…
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Artikel Jurnal
Coagulation factor V as a novel regulator of tumor immunity in melanoma
Abstract Background Recent advances in melanoma treatment, including targeted therapies and immunotherapies, have improved patient outcomes. The discovery of molecular targets is crucial, enabling more precise treatment strategies that address specific genetic mutations. Our study delves into the…
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Artikel Jurnal
Identification of novel circulating protein biomarkers for hepatocellular carcinoma superior to alpha-fetoprotein through a stemness index and secretome analysis
Abstract Objective This study aimed to identify novel circulating protein biomarkers for hepatocellular carcinoma (HCC) superior to alpha-fetoprotein (AFP) by integrating tumor stemness index and secreted protein screening, and to explore their roles in prognosis, immune microenvironment, and tumor…
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Artikel Jurnal
Overexpression and prognostic value of aspartate β-hydroxylase in lung adenocarcinoma: a comprehensive study based on bioinformatics and clinical tissue sample validation
Abstract Background Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide. Although established biomarkers guide targeted therapy, their utility in prognostic stratification remains limited. In this study, we. Methods ASPH mRNA expression across pan-cancers and in LUAD…
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Artikel Jurnal
Anatomical location of metastatic sentinel lymph node and clinicopathological characteristics for predicting risk of non-sentinel lymph node metastasis
Abstract Background 30 to 70% of patients with positive sentinel lymph nodes (SLNs) in early breast cancer do not develop non-SLN metastases. They are exposed to the potential complications and sequelae of axillary lymph node dissection (ALND) without gaining additional therapeutic benefit…
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Artikel Jurnal
Bone mineral density as a prognostic marker in patients with non-small cell lung cancer undergoing neoadjuvant chemoimmunotherapy
Abstract Background Non-small cell lung cancer (NSCLC) is the most common lung cancer, and surgery is the primary curative treatment approach. Recently, neoadjuvant immunotherapy combined with chemotherapy (NICT) has become an important strategy. However, not all patients benefit, underscoring the…
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Artikel Jurnal
miR-146b-5p promotes prostate cancer progression by targeting and negatively regulating FOXO3 and its mechanism
Abstract Aims To investigate the expression and potential mechanism of action of miR-146b-5p in prostate cancer (PCa). Methods Quantification of miR-146b-5p and FOXO3 expression by RT-qPCR was performed on 140 paired PCa and normal adjacent tissues. Kaplan-Meier curves and Cox regression models…
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Artikel Jurnal
The dual oncogenic and protective roles of hashimoto’s thyroiditis in papillary thyroid carcinoma: a cohort-based meta-analysis
Abstract Background The clinical impact of Hashimoto’s thyroiditis (HT) in papillary thyroid carcinoma (PTC) remains controversial. HT has been implicated in multifocal tumorigenesis but also linked to more favorable tumor biology. This meta-analysis aimed to clarify their association. Methods This…
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Artikel Jurnal
The application of intraoperative strategies to reduce protective stoma in mid and low rectal cancer: a retrospective study utilizing indocyanine green and precise anatomical techniques
Abstract Background Mid and low rectal cancer is among the most prevalent malignancies worldwide. Total mesorectal excision (TME) remains the standard surgical approach for these cancers. However, anastomotic leakage (AL) represents a significant complication associated with laparoscopic total…
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