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Arthritis Research & Therapy
Scopus
ISSN 1478-6362 · BMC · 2,575 articles in the index
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Journal Article
Microvascular imaging is superior to power doppler in synovitis vascular flow detection in rheumatoid arthritis using the OMERACT-EULAR scoring system
Abstract Introduction Superb Microvascular Imaging (SMI) uses an adaptive algorithm that improves the visualization of vessels with low-velocity blood flow. Power Doppler (PD) imaging is routinely used in clinical practice but includes a wall filter, resulting in signal loss from small blood…
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Journal Article
Real-world validation of the SLERPI diagnostic model with concordance and discordance analysis across established SLE classification criteria
Abstract Objective Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which early and atypical presentations frequently challenge existing classification frameworks. The Systemic Lupus Erythematosus Risk Probability Index (SLERPI) was developed as a probabilistic diagnostic…
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Journal Article
IL-35 enhances IL-10⁺ breg-mediated immunoregulation and attenuates inflammation and fibrosis in systemic sclerosis
Abstract Objective This study aimed to explore the role of interleukin-35 (IL-35)-mediated regulatory B cells (Bregs) in modulating inflammation and fibrosis in systemic sclerosis (SSc). Methods Peripheral blood and skin samples from 132 treatment-naïve SSc patients and 58 healthy controls (HCs)…
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Journal Article
Establishing C-X-C motif chemokine receptor 4 as a novel imaging target in giant cell arteritis
Abstract Background PET imaging in giant cell arteritis (GCA) is crucial for diagnosis. New tracers such as C-X-C motif chemokine receptor 4 (CXCR4) enable to directly visualize inflammatory cells as they are expressed on leukocytes. We aimed to test the value of CXCR4-targeted PET in GCA. Methods…
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Journal Article
Novel advances in juvenile idiopathic arthritis associated uveitis
Abstract Introduction Juvenile idiopathic arthritis–associated uveitis (JIA-U) is an important cause of childhood and adult visual impairment. Advances in surveillance approaches and treatment have improved outcomes, yet delayed detection and treatment-refractory disease remain substantial…
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Journal Article
Development of a confidence-based Natural Language Processing tool to identify inflammatory arthritis from non-inflammatory conditions in Rheumatology medical notes
Abstract Introduction In chronic diseases the length and redundancy of medical records can hamper the accurate interpretation of the individual clinical history, and we hypothesize that Natural Language Processing (NLP) may be used to optimize information from unstructured texts in electronic…
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Journal Article
Soluble CD13 in systemic sclerosis: clinical observations and transcriptomic insights from peripheral blood
Abstract Background Soluble CD13 (sCD13), generated through cleavage of membrane-bound CD13 by matrix metalloproteinase-14 (MMP14), exhibits proinflammatory, angiogenic, and arthritogenic properties. Its known receptors include bradykinin receptor B1 (B1R) and protease-activated receptor 4 (PAR4)…
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Journal Article
Sex differences in pain-related biopsychosocial assessments in patients with axial spondyloarthritis
Abstract Background In axial spondyloarthritis (axSpA), (back)pain is the key symptom and often linked to inflammation. However, knowledge on sex-related differences in pain is limited. Therefore, our study aim was to explore sex differences in a broad spectrum of pain-related biopsychosocial…
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Journal Article
Gender differences in the clinical features and quality of life of Japanese patients with systemic lupus erythematosus: a cross-sectional study based on the LUNA registry
Abstract Background Gender differences in clinical manifestations and disease progression of systemic lupus erythematosus (SLE) have been well documented; however, there is a paucity of literature on the gender differences in the quality of life (QOL) of patients with SLE, especially in the context…
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Journal Article
Development of a scoring system to assist clinicians in the early referral of patients with suspected juvenile idiopathic arthritis: the EasyJIA score
Abstract Objective Juvenile idiopathic arthritis (JIA) is the most common chronic pediatric rheumatic disease. Early referral to a specialized center is crucial for prompt diagnosis and treatment. This study aims to develop and validate a scoring system to assist clinicians in efficiently…
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Journal Article
Mental health needs of children and young people with arthritis
Abstract Juvenile Idiopathic Arthritis (JIA) is the most common paediatric rheumatological condition, affecting approximately 1 in 1,000 children and young people. It is a heterogeneous chronic disease characterised by persistent joint inflammation, often requiring long-term management to achieve…
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Journal Article
Micro-computed tomographical and histopathological analyses of medial tibial plateaus from patients with subchondral insufficiency fracture or osteoarthritis of the knee
Abstract Background Subchondral insufficiency fracture of the knee (SIFK) is a rare and rapidly progressing knee joint disease. The typical diagnostic finding of SIFK by magnetic resonance imaging (MRI) is a subchondral hypointense line around the bone marrow lesions (BMLs), which are also commonly…
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Journal Article
FSCN1 induces subchondral bone sclerosis in osteoarthritis via modulating actin cytoskeleton dynamics and YAP signaling
Abstract Background Subchondral bone is a dynamic tissue maintained by bone remodeling and responded rapidly to mechanical loading, which is strongly associated with cartilage degradation in osteoarthritis (OA), but the underlying mechanisms of which is still blurring. Methods Experimental OA mice…
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Journal Article
Real-world comparative effectiveness of sarilumab versus Janus kinase inhibitors as monotherapy in rheumatoid arthritis
Abstract Background Sarilumab (SAR), an interleukin-6 receptor inhibitor (IL-6Ri), and Janus kinase inhibitors (JAKi) are approved options for rheumatoid arthritis (RA) when methotrexate (MTX) cannot be used. Real-world evidence for MTX-free monotherapy remains limited. Methods We conducted a…
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Journal Article
Impact of symptom duration on the short- and long-term efficacy of bimekizumab in axial spondyloarthritis: results up to 2 years
Abstract Background Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A, showed efficacy to 2 years in patients with axial spondyloarthritis (axSpA). In this post hoc analysis, we compare the impact of shorter versus longer symptom duration on the efficacy…
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Journal Article
PARP-1 prevents osteoarthritis pathogenesis by inhibiting apoptosis in chondrocytes: an animal study
Abstract Background Osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage breakdown, synovial inflammation, and subchondral bone changes. Chondrocyte apoptosis is a key contributor to cartilage degradation in OA. Poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme involved…
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Journal Article
A BAFF/APRIL dual inhibitor for the treatment of systemic lupus erythematosus: a long-term, observational, real-world study
Abstract Background This study evaluated the efficacy and safety of telitacicept (a B-cell inhibitor targeting B cell-activating factor [BAFF] and a proliferation-inducing ligand [APRIL]) in patients with systemic lupus erythematosus (SLE) in real clinical settings. Methods This was a long-term…
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Journal Article
Interleukin-6 blockade modulates monocyte recruitment to protect against diastolic dysfunction associated with inflammatory arthritis
Abstract Background There is an unmet clinical need to manage heart failure with preserved ejection fraction in people with rheumatoid arthritis (RA). One hurdle is the absence of preclinical models to study pathology and pharmacology in settings of inflammatory arthritis. In addition, there is…
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Journal Article
Influence of major trauma and lower limb loss on radiographic progression and incidence of knee osteoarthritis and pain: a comparative and predictive analysis from the ADVANCE study
Abstract Objective Knee osteoarthritis (OA) is a leading cause of disability globally, with previous injury a key risk factor. This study investigates the relationship between the risk of progression and incidence of knee radiographic OA (rOA) and pain (KP) with major traumatic injury and identify…
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Journal Article
Difficult to manage axial spondyloarthritis patients have high burden of pain-related comorbidities and adverse long-term outcome
Abstract Background Difficult to manage (D2M) axial spondyloarthritis (axSpA) is an evolving clinical concept. We aimed to assess the prevalence, predictors and long-term outcomes of D2M axSpA. Methods Prospective single center cohort study of axSpA patients starting targeted agents (01/01/2007…
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