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Journal of Translational Medicine
Scopus
ISSN 1479-5876 · BMC · 8.781 artikel di indeks
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Artikel Jurnal
Circulating cellular communication network factor 1 (CCN1) as a liquid biopsy marker indicating progression in advanced melanoma
Abstract Background Cellular communication network factor 1 (CCN1, also referred to as CYR61), a secreted matricellular protein, has been implicated in tumor progression and stromal remodeling within the metastatic tumor microenvironment of melanoma. Here, we investigated, for the first time…
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Artikel Jurnal
IL1β+ macrophages promote intestinal fibrosis in Crohn’s disease by secreting AREG to activate PI16+ fibroblasts
Abstract Background Excessive extracellular matrix deposition is a hallmark of intestinal fibrosis in Crohn’s disease (CD), with fibroblasts playing a central pathogenic role. This study aimed to elucidate how macrophages regulate fibroblast activity and contribute to intestinal fibrosis…
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Artikel Jurnal
Reinforcement learning–based WSI diagnostic system for cervical squamous cell carcinoma and precancerous lesions
Abstract Background The prevention of cervical cancer relies on the accurate histopathological grading of its precursor lesions, particularly Squamous Intraepithelial Lesions (SIL), which can progress to Squamous Cell Carcinoma (SCC) if left undiagnosed or misclassified. However, the diagnostic…
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Artikel Jurnal
Fecal microbiota transplantation promotes Wnt3a-mediated hippocampal neurogenesis in a rat model of chronic cerebral hypoperfusion
Abstract Background Limited data support the beneficial effects of fecal microbiota transplantation (FMT) against intracranial ischemic injury under chronic cerebral hypoperfusion (CCH). However, a comprehensive understanding is lacking, hindering its clinical translation. In the present study, we…
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Artikel Jurnal
PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications
Abstract Background Phospholipase Cγ2 (PLCG2) serves as a central signal transducer within immune and neural lineages, catalyzing the conversion of membrane phosphoinositides into second messengers to regulate intracellular Ca2+ dynamics. By integrating inputs from B-cell receptor (BCR) signaling…
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Artikel Jurnal
Patient-derived organoids predict responses to chemotherapy and PARP inhibitors in advanced ovarian cancer
Abstract Background While tumor organoids hold promise for personalized medicine, clinical validation of epithelial ovarian cancer (EOC) organoids as predictors of therapeutic efficacy-particularly for PARP inhibitors (PARPi)-remains unestablished. Methods Patient-derived organoids (PDOs) were…
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Artikel Jurnal
Mitochondrial transfer: a Janus-faced force in health and disease
Abstract Mitochondrial transfer is increasingly recognized as a dynamic form of intercellular communication that reshapes how we understand tissue homeostasis, immune function, and disease progression. Rather than being a passive event, mitochondrial transfer involves the movement of organelles…
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Artikel Jurnal
Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepatocellular carcinoma via targeting the PRMT1-SREBF1 axis-mediated lipid metabolism
Abstract Background Ginsenosides, such as ginsenoside RG3, demonstrate antitumor potential in hepatocellular carcinoma (HCC) and are often combined with cantharidin (CTD) in traditional Chinese medicine to achieve synergistic effects while mitigating CTD’s toxicity. However, the precise molecular…
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Artikel Jurnal
Plant-derived exosome-like nanovesicles: dual-function platforms for anticancer therapy and drug delivery
Abstract Background Plant-derived exosome-like nanovesicles (PDELNs) are nanoscale bilayered lipid vesicles secreted by plant cells that encapsulate a range of bioactive cargoes, including lipids, proteins, and nucleic acids. These vesicles play a crucial regulatory role in various…
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Artikel Jurnal
Triple-remodeling of tumor microenvironment through hyaluronidase-assisted folate-targeted lipid nanoparticle-mediated siVEGF/siPD-L1 for enhanced tumor immunotherapy
Abstract Background In tumor therapy, traditional single-treatment methods often fail to achieve ideal results because of problems like the complex tumor microenvironment, immune escape mechanisms, and abnormal blood vessel formation. Although there are now several combined treatment strategies…
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Artikel Jurnal
Venetoclax induces mitochondrial apoptosis and autophagy to overcome arsenic trioxide resistance in acute promyelocytic leukemia
Abstract Background Arsenic trioxide (ATO) therapy is highly successful in majority of acute promyelocytic leukemia (APL) patients with PML-RARA fusion oncoprotein. However, after initial response to therapy, 8–10% experienced relapse and became resistant to ATO. ATO-resistant APL cells show…
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Artikel Jurnal
Single-cell transcriptome analysis reveals mechanisms by which hippocampal deep brain stimulation promotes neurorepair and microglial subpopulation remodeling in ischemic stroke
Abstract Background In patients with ischemic stroke, the hippocampus is one of the most severely damaged regions of the brain; however, the optimal parameters for hippocampal deep brain stimulation in these patients remain unknown. The underlying mechanism of hippocampal deep brain stimulation in…
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Artikel Jurnal
Evaluation of the efficacy of optical genome mapping in prenatal diagnosis: a retrospective cohort study
Abstract Background Optical genome mapping (OGM) is an emerging cytogenetic method for concurrently detecting structural variants (SVs) and copy number variants (CNVs). However, its clinical application in prenatal diagnosis remains underexplored. Methods This study retrospectively evaluated the…
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Artikel Jurnal
Trajectories of adiposity indices and the risk of cardiovascular disease and mortality: a prospective cohort study
Abstract Background While novel adiposity indices such as the body roundness index (BRI), a body shape index (ABSI), the visceral adiposity index (VAI), and the Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) index outperform body mass index (BMI) in predicting cardiovascular…
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Artikel Jurnal
Cell-type specific activation of the cGAS-STING pathway in tumor immunotherapy: mechanisms and therapeutic implications
Abstract Background The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway acts as a pivotal innate immune sensor that detects cytosolic DNA and links genomic instability to antitumor immune activation. Therapeutic activation of this pathway has garnered substantial…
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Artikel Jurnal
Dietary interventions and the gut microbiota: a systematic literature review of 80 controlled clinical trials
Abstract Background The gut microbiota are increasingly recognised as key mediators of diet-related health outcomes. This systematic review primarily aimed to comprehensively evaluate associations between dietary interventions and gut microbiota in healthy and clinical adult populations, utilising…
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Artikel Jurnal
A 3-tier information fusioned framework featuring explainable deep active optimized CRNet for accurate heart disease prediction
Abstract Background Heart disease remains a leading cause of global morbidity and mortality, emphasizing the need for early and accurate prediction. Traditional models, however, often struggle with high class imbalance, limited accuracy, inadequate hyperparameter tuning, reliance on sparsely…
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Artikel Jurnal
PET imaging utility of a novel Aβ-tracking PET radiotracer, [18F]FC119S in aged vervet monkeys
Abstract Background Alzheimer’s disease is characterized by the deposition of amyloid-beta (Aβ) plaques, necessitating early detection and reliable biomarkers for effective intervention. Non-human primates, particularly aged vervet monkeys, offer valuable models for studying age-related Aβ…
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