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Journal of Pharmacy & Pharmaceutical Sciences
Scopus
ISSN 1482-1826 · Frontiers Media S.A. · 816 artikel di indeks
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Artikel Jurnal
Integrative deep learning strategies to enhance early-stage drug discovery: optimizing computational structure–activity modeling for pharmacotherapeutic innovation
The integration of computational intelligence into therapeutic development is increasingly important for accelerating early-stage drug discovery and improving compound prioritization. In this study, we developed an optimized neural network–based predictive framework to support the identification of…
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The effect of cryoprotectant and storage conditions on the aggregation of poly(ethylene glycol)-poly(α-benzyl carboxylate-ε-caprolactone) nanoparticles
IntroductionThe preparation of nanoparticles (NPs) in aqueous media leads to thermodynamic instability and aggregation during storage. The objective of this study was to identify an optimum condition for the storage of poly(ethylene glycol)-poly(α-benzyl carboxylate-ε-caprolactone) (PEG-PBCL) NPs…
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Rethinking asthma therapy, part 1: transdermal delivery of β2-agonists
Asthma and allergies are closely related conditions affecting millions of people around the world. Current treatment options cover many classes of drugs for both acute and ongoing conditions. β2-agonists, leukotriene modifiers, and corticosteroids represent some of the common types of drugs…
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Artikel Jurnal
Rethinking asthma therapy, part 2: transdermal strategies for adjunct asthma and allergy treatments
Asthma and allergies affect millions of people globally. Avoiding triggers and allergens is a basic management technique for all asthma subtypes (>80% of asthma patients also suffer from allergies), and pharmacological treatment is the cornerstone for acute exacerbations and ongoing maintenance…
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Career commitment and professional satisfaction among Romanian pharmacy graduates: a nationwide cross-sectional survey
IntroductionProfessional satisfaction is a key determinant of career commitment and workforce sustainability and retention in the pharmacy sector. The study examines professional satisfaction among Romanian pharmacy graduates by analysing hygiene factors, intrinsic motivators, and perceptions of…
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Availability, utilization, and factors associated with professional pharmacy services in community pharmacies in Saudi Arabia: a cross-sectional study
BackgroundCommunity pharmacists are increasingly expected to provide patient-centered clinical and public health services beyond traditional medication dispensing. However, the availability and utilization of these services in Saudi community pharmacies remain insufficiently characterized.MethodsA…
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Effects of music elements on mycophenolate glucuronidation in rat liver microsomes
BackgroundMycophenolic acid (MPA), a first-line immunosuppressant for preventing transplant organ rejection, exhibits substantial inter- and intra-individual pharmacokinetic variability. We hypothesized that music elements (tempo, rhythm, and harmony) can affect the formation of MPA glucuronide…
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Carbapenem-based versus non-carbapenem therapy for hospital-acquired and ventilator-associated pneumonia in a resource-limited setting: a retrospective cohort study of clinical outcomes
BackgroundHospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are major causes of in-hospital mortality and antimicrobial resistance (AMR), particularly in low- and middle-income countries (LMICs). Carbapenems are commonly used due to their broad-spectrum activity; however…
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Old drugs, new weapons: current trends in repurposing therapies against antimicrobial resistance
Antimicrobial resistance (AMR) is a globally accelerating issue threatening the efficacy of existing treatments. Repurposing approved drugs for the development of new antimicrobial agents reduces the development cost and risk. The clinical potential of repurposed medications for AMR is essential to…
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Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms
Ophthalmic diseases are a growing global cause of visual impairment, driven by population aging and the rising prevalence of diabetes mellitus. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist widely used for dyslipidemia, has emerged as a candidate for therapeutic…
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Artikel Jurnal
Age-related risk factors for leftover drugs: a lifespan analysis in community pharmacies
IntroductionMedication adherence is a critical global challenge because suboptimal adherence reduces therapeutic efficacy and increases healthcare costs. While leftover drugs are vital indicators of potential adherence-related challenges, age-specific factors contributing to their occurrence…
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Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review
BackgroundThe pharmaceutical industry faces a productivity crisis, with only ∼10% of candidates reaching approval and development costs exceeding $1-2 billion per drug. Traditional preclinical models, particularly animal studies, show limited predictive validity for human outcomes…
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Innovative hyaluronic acid-decorated quatsomes for enhanced renal targeting: design, optimization and in-vivo biochemical and nephroprotective assessments
The kidney plays a critical role in metabolite excretion, fluid regulation, and homeostasis, yet remains highly vulnerable to structural and functional disorders. Kidney diseases represent a major global health burden, often progressing to chronic complications due to the limited efficacy and poor…
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Drug-related problems and their predictors in pediatric community-acquired infections: the role of pharmacist-led interventions in Pakistan
PurposeDrug-Related Problems (DRPs) are a leading cause of preventable harm to hospitalized children, yet the data from low- and middle-income countries (LMICs) are limited. This study aimed to determine the prevalence, severity and determinants of DRPs in children with community-acquired…
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Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats
Methamphetamine (METH)-induced agitation, a major concern in acute METH intoxication, is currently treated with benzodiazepines. Due to current polysubstance use patterns in METH consumption, this treatment may fatally exacerbate respiratory depression produced by opioid adulterants or…
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Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients
ObjectivesMycophenolic acid (MPA) and tacrolimus (TAC) exhibit substantial pharmacokinetic variability, and volumetric absorptive microsampling (VAMS) offers a minimally invasive alternative for therapeutic drug monitoring (TDM). This study aimed to develop a VAMS-based method for MPA and TAC…
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Artikel Jurnal
Enhancement of oral bioavailability of risedronate through xyloglucan rafts
Bisphosphonates irritate the stomach and oesophagus and have a very limited absorption. The purpose of this study was to increase risedronate (RDN) oral bioavailability by causing a raft to form in the stomach. The creation of a raft prevents the irritation of the stomach and oesophagus caused by…
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Artikel Jurnal
Refined pharmacovigilance assessment of immune checkpoint inhibitors-related bullous pemphigoid: a multi-methodological approach utilizing FAERS database
ObjectivesTo evaluate the potential risk of bullous pemphigoid (BP) in patients treated with immune checkpoint inhibitors (ICIs) and to characterize ICI-related BP (irBP) using the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database.MethodsThe present study…