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Drug Delivery
Scopus
ISSN 1521-0464 · Taylor & Francis Group · 1.494 artikel di indeks
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Artikel Jurnal
Unlocking the potential of mesoporous silica nanoparticles: balancing biomedical applications and safety concerns
Mesoporous silica nanoparticles (MSNs) have garnered significant attention across various disciplines, including chemistry, physics, and materials science, owing to their distinctive properties and functionalities. Numerous studies have demonstrated that MSNs possess several advantageous…
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Artikel Jurnal
Advancements and challenges in ophthalmic microneedles to treat eye diseases
By 2050, more than 61 million people worldwide are expected to lose their vision due to conditions like age-related macular degeneration, glaucoma, diabetic retinopathy, and uveitis (Bourne et al. 2021). This anticipated rise highlights the urgent need for more effective treatment options. While…
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Artikel Jurnal
Microalgae as novel drug-delivery system for biomedical field
Currently, increasing attention is being paid to the extraction and utilization of materials with special biological activities in nature or for medical applications. Owing to their unique biological characteristics and diverse application potential, microalgae are among the most promising…
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Artikel Jurnal
Introducing personalized patient care in overactive bladder management using the MedRing OAB system for intravaginal oxybutynin administration
Although numerous drugs have been developed for intravaginal administration, the implementation of personalized intravaginal treatment options is limited. The MedRing overactive bladder (OAB) system is a medical device for intravaginal oxybutynin administration via patient-controlled schedules. The…
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Artikel Jurnal
Harnessing fluorescent probes for molecular diagnosis and theranostics of atherosclerosis
Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, posing a serious threat to human health. Atherosclerosis (AS), the pathological basis of most cardiovascular diseases, is characterized by arterial wall thickening caused by chronic inflammation. In recent years…
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Artikel Jurnal
The development of DNA delivery system based on ionic liquid and carboxylic acid modified polyethyleneimine
Recombinant DNA vaccines offer significant potential for disease prevention and therapy, but their clinical success is often limited by poor immunogenicity, low cellular uptake, instability, and inefficient delivery without proper carriers. To address these challenges, we developed a series of…
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Artikel Jurnal
Re-engineering insulin for oral delivery: structural modifications, advanced formulation strategies, and future directions
Oral insulin delivery represents a transformative approach to diabetes management, offering improved patient compliance and physiological insulin delivery patterns compared to subcutaneous injection. However, multiple gastrointestinal barriers, including enzymatic degradation, mucus entrapment…
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Artikel Jurnal
Long-term management of psoriasis recurrence via modulation of cutaneous microbiome: synergistic topical therapy with blue light and aptamer-functionalized curcumin formulation
The recurrence following the discontinuation of medication is a formidable challenge in managing psoriasis. Changes in the microbiome accompany the onset of psoriasis relapse, highlighting a potential therapeutic modality. To evaluate the superiority of the topical administration of…
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Artikel Jurnal
Folate-targeted gold nanoparticles for doxorubicin delivery in tumor spheroids
Targeted drug delivery systems represent a promising strategy for enhancing the efficacy and specificity of cancer therapy. In this study, 35 nm folate-targeted gold nanoparticles are presented as nanoparticle–drug conjugates obtained by anchoring on their surface lipoyl terminating doxorubicin…
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Cerium oxide nanoparticles: antioxidant properties in silicosis treatment and biomedical application prospects—a dialectical consideration
Silicosis is a progressive fibrotic lung disease precipitated by chronic inhalation of crystalline silica. Uptake of silica particles by alveolar macrophages initiates a cascade of persistent inflammation and oxidative stress, in which reactive oxygen species (ROS) are key mediators of cellular…
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Artikel Jurnal
A macrophage-mimetic nanocarrier co-loaded with geraniol and FK13-a1 for MRSA-induced acute lung injury
Current clinical strategies for Methicillin-resistant Staphylococcus aureus (MRSA)-induced acute lung injury (ALI) predominantly focus on single-approach interventions such as anti-inflammatory therapy. However, due to the complex, multi-pathway pathological network underlying the disease…
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Artikel Jurnal
ROS-triggerable dual nanocoated probiotics for inflammatory bowel disease treatment
Inflammatory bowel disease (IBD), an immune-mediated chronic gastrointestinal disease, is difficult to treat because its specific pathogenic mechanisms are currently unclear, and its recurrence rate is high. Probiotic therapies have been used to treat IBD; however, challenges, including poor…
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Artikel Jurnal
Unlocking the “undruggable”: current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation
Extracellular and membrane-associated proteins are essential in signal transmission, immunological control, and disease pathogenesis; nonetheless, their ‘undruggable’ characteristics have historically impeded drug discovery. The targeted protein degradation (TPD) technologies provide innovative…
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Artikel Jurnal
Genetically engineered M13 phage-mediated H9N2 DNA vaccine with enhanced mucosal and systemic immune responses in mice
Vaccine adjuvants and delivery systems have long been used in DNA vaccines to enhance immunogenicity. In this study, we developed a DNA vaccine delivery platform by combining N-2-hydroxypropyl trimethyl ammonium chloride chitosan/carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) with a…
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Artikel Jurnal
Bioengineered extracellular vesicles integrating anti-EphA2 recognition and oxaliplatin delivery for pancreatic cancer therapy
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal solid tumors due to its dense desmoplastic stroma, poor vascular perfusion, and the limited intratumoral delivery of chemotherapeutic agents such as oxaliplatin (OXA). Extracellular vesicles (EVs) offer a biocompatible platform…
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Artikel Jurnal
Numerical simulation of PDRN iontophoresis: comparison with passive diffusion and key parameter analysis
Polydeoxyribonucleotide (PDRN) is a bio-derived therapeutic agent known to exhibit regenerative, angiogenic, and anti-inflammatory effects. However, its relatively large molecular size limits penetration across the skin barrier, thereby reducing the feasibility of noninvasive transdermal delivery…
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Artikel Jurnal
Redefining intranasal brain delivery: from nasal entry to meaningful parenchymal and cellular exposure
Nose-to-brain (N2B) delivery is a promising noninvasive strategy to circumvent the blood‒brain barrier (BBB). However, the clinical translation of N2B platforms remains hindered by a conceptual oversimplification that equates crude central nervous system (CNS) exposure with effective therapeutic…
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Artikel Jurnal
Dual-ligand-modified cantharidin nanoparticles for the treatment of hepatocellular carcinoma via the inhibition of Ephb4
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, yet conventional chemotherapy is limited by poor tumor specificity and severe toxicity. Cantharidin (CTD), a natural antitumor agent, is hindered by nephrotoxicity and hepatotoxicity. This study aimed to construct a…
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Artikel Jurnal
Self-assembled non-steroidal anti-inflammatory drug-peptide hydrogel to effectively mitigate ocular inflammation
Pranoprofen (Pra) eye drop has been widely used in clinical practice for the efficient mitigation of ocular inflammation, but it often suffers from poor bioavailability owing to the existence of various ocular barriers (i.e. tear barrier and corneal epithelial barrier). In this study, we rationally…
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Artikel Jurnal
Design and characterization of a resveratrol spray-dried inhalable formulation for pulmonary delivery with in vivo pharmacokinetic and toxicological evaluation
Resveratrol is a polyphenolic compound with therapeutic potential for pulmonary diseases, yet its use is limited mostly due to low oral bioavailability. Inhalable powder formulations are a promising strategy to help overcome those challenges. Here, we report the development and physicochemical…
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