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KAT2A promotes NLRP3-mediated trophoblast pyroptosis in preeclampsia by the succinylation

Shaoping Huang; Qing Su; Xuechun Li dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Background and objective Trophoblast pyroptosis contributes to the pathogenesis of preeclampsia (PE). Succinylation is a posttranslational modification that is involved in the progression of various diseases. This study aimed to explore the role of the succinyltransferase KAT2A in PE by evaluating…

The role of continuous analgesia during labor in pregnant women with hypertensive disorders: a comparative study on pain relief, anxiety, depression, and maternal-infant outcomes

Tiantian Huang; Hongfang Liu; Jing Ren dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective To evaluate and compare the effects of continuous analgesia versus standard pain management on pain intensity, psychological status (anxiety and depression), and maternal-infant outcomes in pregnant women with hypertensive disorders.Methods This retrospective cohort study analyzed 124…

Comparison of the burden of maternal hypertensive disorders between China and the globe from 1990 to 2023: epidemiological trends and age-period-cohort analysis

Bairong Liu; Dandan Yan

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective To compare epidemiological trends and burden of maternal hypertensive disorders (MHD) between China and the globe from 1990 to 2023 and project future trends through 2035.Methods Based on Global Burden of Disease (GBD) 2023 data, temporal trends and age-period-cohort effects were analyzed…

SII serves as an independent diagnostic indicator for GDM and is regulated by placental 5-HT/NF-κB signaling

Weizhao Lin; Yujuan Tang; Jiahua Chen dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Gestational diabetes mellitus (GDM) poses a significant threat to perinatal health. Diagnosis based solely on glycemic parameters shows limited accuracy. The Systemic Immune-Inflammation Index (SII), a quantitative marker of inflammation, may improve diagnostic precision. This study analyzed…

Association of systemic inflammatory response index with severity of preeclampsia

Lina Gao; Yan Dong; Xiaohui Liu dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective The systemic inflammatory response index (SIRI), a novel and integrated hematological index calculated as (neutrophil count × monocyte count)/lymphocyte count, has been recognized as a reliable marker of systemic inflammation. This article undertakes an analysis of clinical data from…

Neuroimaging characteristics and clinical outcomes of posterior reversible encephalopathy syndrome in preeclamptic and eclamptic patients

Ahmet Beyazıt; İbrahim Barışcan Soydan; Kenan Serdar Dolapçıoğlu dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Posterior reversible encephalopathy syndrome (PRES) is a neurological complication linked to preeclampsia and eclampsia. This study compared the clinical and radiological features of PRES in patients with these conditions. This retrospective single-center cohort study from 2010 to 2024 included…

The role of early second trimester maternal serum cadherin-11 levels in the prediction of preeclampsia

Naziye Gurkan; Samettin Celik; Neset Gumusburun dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective Preeclampsia is a significant pregnancy complication associated with abnormal placental formation. Cadherin-11, a cell adhesion molecule, plays a role in trophoblast differentiation and placental development. The aim of this study was to evaluate the relationship between cadherin-11…

Towards an understanding of COVID-19-associated preeclampsia

A. Medel-Martinez; A. Cebollada-Solanas; M. Strunk dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Introduction SARS-CoV-2 infection during pregnancy has been associated with higher rates of preeclampsia (PE). While placental abnormalities resembling PE have been reported in COVID-19 pregnancies, the molecular mechanisms underlying the association remain unclear.Methods We conducted bulk RNA…

Expression of concern: Maternal and fetal outcome in de novo preeclampsia in comparison to superimposed preeclampsia: a two-year observational study

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

A preeclampsia prediction model incorporating methylenetetrahydrofolate reductase, vitamin D receptor, and uterine artery pulsatility index

Mei Xu; Ge Yang; XingBo Zhong dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective This study evaluated the predictive value of methylenetetrahydrofolate reductase (MTHFR) rs1801133 and vitamin D receptor (VDR) FokI rs2228570 polymorphisms combined with uterine artery pulsatility index (PI) for preeclampsia (PE), and explored mediating pathways underlying genetic…

Left ventricular hypertrophy as a predictor of adverse maternal and neonatal outcomes in chronic hypertension in pregnancy: a multicenter study

Bei Zhang; Guilong Pan; Wei Wang dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective The impact of chronic hypertension (CHTN) combined with left ventricular hypertrophy (LVH) on adverse maternal and fetal pregnancy outcomes remains unclear.Methods This multicenter retrospective cohort study included pregnant women with CHTN from four tertiary hospitals in China. Baseline…

MIR210HG promotes preeclampsia progression through CDHR5

Ningxia Sun; Lu Zhang; Jine Xu dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective Early diagnosis of preeclampsia (PE) remains challenging. We previously linked the long non-coding (lnc) RNA MIR210HG to pathological placental development. Here, we investigated its differential expression, pathophysiological phenotypic specificity, and non-invasive diagnostic potential…

Biochemical markers of cardiac dysfunction in pregnancies with preeclampsia and fetal growth restriction

Sabina Horejskova; Alexandra Regendova; Petra Hanulikova dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective This study aimed to identify which subtypes of preeclampsia and fetal growth restriction (FGR) are associated with the greatest maternal cardiovascular strain, as indicated by laboratory biomarkers of cardiac dysfunction.Methods Women were recruited at diagnosis and serum levels of…

Hypertensive disorders during pregnancy and cognitive outcomes in children: the ALSPAC study

Berihun Dachew; Getinet Ayano; Rosa Alati

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective This study aimed to examine the associations between hypertensive disorders during pregnancy and intelligence quotient (IQ) in children at the ages of 8 and 16 years.Methods Our study sample comprised participants in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort, an…

The economic burden of preeclampsia: a systematic review

Adili Adilan; Haoran Zhan; Yanan Hu dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective Preeclampsia is a serious pregnancy complication associated with substantial maternal and infant morbidity worldwide. The adverse outcomes related to preeclampsia increase healthcare costs, highlighting the importance of quantifying its economic burden to inform healthcare policy and…

Endoplasmic reticulum stress-related genes drive M1 macrophage polarization in preeclampsia via modulating metabolic reprogramming: a bioinformatic study

Chunzi Xu; Ruikun Hu; Yun Lu dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Background Preeclampsia (PE), a serious obstetric complication impacting maternal and fetal health, still lacks reliable biomarkers owing to limited sensitivity, specificity, and disease heterogeneity.Methods Differentially expressed genes (DEGs) were identified from placental samples in GSE114691…

Correction

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Advanced maternal age is a risk factor for both early-onset and late-onset hypertensive disorders of pregnancy: the Japan environment and children’s study

Kazuma Tagami; Hasumi Tomita; Noriyuki Iwama dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective Advanced maternal age (AMA, ≥35 years), particularly prevalent in Japan, is associated with adverse perinatal outcomes, including hypertensive disorders of pregnancy (HDP), which vary in severity based on the timing of onset (early-onset and late-onset). This study aimed to investigate…

Maternal hypertensive disorders in East Asia, 1990−2023: incidence, deaths, DALYs and maternal mortality in women aged 20−54 years using GBD 2023

Xianting Yong; Haonan Shi; Yue Meng dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Objective Hypertensive disorders of pregnancy (HDP) are a major cause of illness and death and it can be prevented.Methods We analysed Global Burden of Disease (GBD) 2023 estimates for maternal hypertensive disorders (ICD-10 O10–O16) in six locations (China, Japan, Democratic People’s Republic of…

Identification risk factors for perinatal complications among pregnant women with pulmonary arterial hypertension

Yanyu Wu; Yangjing Zhu; Gaiming Gao dkk.

Hypertension in Pregnancy, Vol. 45 No. 1 · 2026 · Inggris · DOAJ Scopus

Background The risk factors for perinatal complications in pregnant women with pulmonary arterial hypertension (PAH) remain controversial. This study aimed to explore the risk factors and constructed a prediction model for perinatal complications in pregnant women with PAH.Method A total of 116…