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Pathology and Oncology Research
Scopus
ISSN 1532-2807 · Frontiers Media S.A. · 390 artikel di indeks
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Artikel Jurnal
Assessment of the prevalence and consistency of microvascular flow imaging patterns in focal nodular hyperplasia
ObjectivesTo identify characteristic vascular features of focal nodular hyperplasia (FNH) on microvascular flow imaging (MVFI) and assess the utility of MVFI in FNH diagnosis.MethodsThis retrospective study included B-mode ultrasound (US) and MVFI scans of 41 FNHs, 21 hepatocellular carcinomas…
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Microsatellite status and its correlation with clinicopathological features in gastric carcinoma: insights from a retrospective study in Northern Pretoria
Introduction/backgroundGastric carcinomas (GC) are heterogeneous malignancies characterised by distinct histological and molecular subtypes. The microsatellite instability (MSI) molecular subtype, resulting from deficient DNA mismatch repair (dMMR), accounts for approximately 22% of global GC…
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Sample adequacy in bronchoscopic ROSE: comparison between laboratory specialist and pathologist
Rapid on-site evaluation (ROSE) during bronchoscopy provides the opportunity to assess the adequacy of the sampling site, thus enabling diagnosis. The rapid evaluation of smears is typically performed by cytopathologists, but this is not always feasible. At our institution, a university-trained…
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Prognostic and predictive factors of immune checkpoint inhibitor therapy in urinary bladder cancer
Immune checkpoint inhibitor (ICI) therapy has become a firmly integrated component of the systemic treatment repertoire for locally advanced and metastatic urothelial bladder cancer (UBC). Over the past decade, multiple ICIs have demonstrated meaningful clinical activity, and their indications have…
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Artikel Jurnal
The uterine secretome initiates growth of gynecologic tissues in ectopic locations: re-evaluating the evidence
The origin of ectopic gynecologic lesions has been debated since 1927, when Sampson first proposed retrograde menstruation as the underlying cause of endometriosis. Reproduction in mammals is an unusually permissive process, enabling the implantation of tissue genetically distinct from the mother…
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Clinicopathological and molecular features of solid pseudopapillary neoplasms: a retrospective series including a small subset of aggressive cases
Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors that are indolent but occasionally present with metastatic or locally invasive disease. Although recurrent CTNNB1 exon 3 mutations define their molecular background, the clinicopathological and molecular features associated with…
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Isolated signals in BCL2, MYC, BCL6, and DDIT3 FISH: implications for genetic alterations and protein dysregulation
ObjectivesFluorescence in situ hybridization (FISH) break-apart probes are widely employed to detect gene rearrangements in malignant tumors. Notwithstanding their utility, the complex genetic alterations in tumors frequently give rise to isolated signals, the mechanisms underlying which remain…
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The effect of the COVID-19 pandemic on TNM status among head and neck cancer patients in Hungary
PurposeHungary ranks among the countries with both the highest incidence and mortality of head and neck cancers worldwide. The COVID-19 pandemic, caused by the SARS-CoV-2 virus placed a significant burden on the healthcare system. Our study aims to investigate its impact on Hungarian head and neck…
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Germline BRCA testing in routine clinical practice: a single-center experience
The identification of gBRCA1/2 mutations in breast cancer patients is crucial. Successful identification of the mutations has the potential to alter disease treatment and healthcare management of patients whose relatives harbor pathogenic/likely pathogenic (P/LP) variants. In this retrospective…
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Efficacy and tolerability of scalp cooling in preventing alopecia during (neo)adjuvant chemotherapy for breast cancer
BackgroundModern chemotherapies substantially improve survival rates in patients with breast cancer; however, its associated adverse effects can markedly diminish quality of life. Chemotherapy-induced alopecia is among the most common and distressing side effects. This study aimed to evaluate the…
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Artikel Jurnal
B vitamins intake and cancer risk: a structured narrative review of evidence on riboflavin, pyridoxine, cobalamin and folate
BackgroundB vitamins play key roles in one-carbon metabolism, DNA synthesis and methylation, and redox regulation. Their potential association with cancer risk remains debated due to heterogeneous findings and methodological limitations across studies.ObjectiveThis structured narrative review aimed…
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Connexin 43 enhances liver metastatic ability of GIST cells in vivo
ObjectiveSmall intestinal gastrointestinal stromal tumors (SI-GISTs) have a higher risk of distant metastasis and recurrence than gastric GISTs (G-GISTs). However, the underlying mechanisms contributing to the poor prognosis of SI-GISTs remain elusive. Previous research has demonstrated that…
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Pediatric extranasal, EBV-negative, extranodal natural killer/T-cell lymphoma; case report
Extranodal natural killer/T-cell lymphomas (ENKTCL) are rare, aggressive neoplasms primarily occurring in adults of Asian or Native American descent. Most are associated with Epstein-Barr virus (EBV) and originate in the nasopharyngeal region. We present the case of a fulminant, disseminated…
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Multiple subcutaneous nodules as the primary presentation of angioimmunoblastic T-cell lymphoma: a case report and literature review
Angioimmunoblastic T-cell lymphoma (AITL) frequently involves the skin, typically presenting as rash or pruritus. However, AITL presenting primarily with multiple subcutaneous nodules is exceedingly rare and poses significant diagnostic challenges, often leading to misdiagnosis. We reported a…
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Proof-of-principle 4-marker spatial profiling reveals distinct, location-independent immune clusters in biliary tract cancers
Biliary tract cancers (BTCs) are aggressive malignancies with limited treatment options. Despite advances with durvalumab plus chemotherapy, prognosis remains poor. The tumor immune microenvironment (TIME) is increasingly recognized as a determinant of immunotherapy response, yet its spatial…
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Case Report: Pancreatic amphicrine-like carcinoma with acinar differentiation harboring a KANK4-RAF1 gene fusion
Pancreatic amphicrine-like carcinoma (ALC) is an exceptionally rare neoplasm characterized by simultaneous exocrine and endocrine differentiation within the same tumour cells. These tumours represent a diagnostic challenge because they must be distinguished from mixed…
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Artikel Jurnal
SPOCK1 overexpression suggests poor prognosis in head and neck squamous cell carcinomas
Head and neck squamous cell carcinomas (HNSCCs) are mostly associated with smoking, alcohol intake, and/or human papillomavirus HPV16 and/or HPV18 infection. However, most tumors are diagnosed at an advanced stage. In the search for biomarkers of HNSCC, we studied the prognostic role of SPOCK1, a…