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Technology in Cancer Research & Treatment
Scopus
ISSN 1533-0338 · SAGE Publishing · 1.645 artikel di indeks
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Artikel Jurnal
Research Progress on Dual-Modal Fluorescence-MRI Molecular Imaging of Molecular Probes in Breast Cancer
Breast cancer (BC), as a prevalent malignancy among women worldwide, requires early and precise diagnosis to improve patient prognosis. This review systematically summarizes the recent research progress of fluorescence -magnetic resonance (MR) dual-modal molecular probes in the diagnosis and…
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A Lightweight Skeletal Muscle Intelligent Segmentation Network Based on Planning CT for Cervical Cancer Radiotherapy
Purpose A lightweight deep learning network SMA-Net was proposed to intelligently segment the skeletal muscle of the third lumbar (L3) level in patients with cervical cancer radiotherapy, and the segmentation performance of the network was evaluated. Methods and Materials A total of 160 eligible…
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Artikel Jurnal
IGF2BP3 Promotes Head and Neck Squamous Cell Carcinoma Progression via the M6A-LDHA-Lactate-H4K8la Axis and E2F2 Activation
Introduction Head and neck squamous cell carcinoma (HNSCC) is characterized by metabolic reprogramming and poor prognosis. While lactate accumulates in HNSCC, how upstream RNA regulation coordinates lactate-associated epigenetic alterations during tumor progression remains unclear. Methods We…
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Innovative Value of Amide Proton Transfer Imaging in the Diagnosis and Treatment of Brain Gliomas: From Basic Principles to Clinical Applications
Conventional magnetic resonance imaging (MRI) exhibits notable limitations in the diagnosis, grading, and therapeutic assessment of gliomas, making it insufficient to meet the demands of precision medicine. As a chemical exchange saturation transfer MRI technique, amide proton transfer (APT)…
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Artikel Jurnal
Outsmarting Metastatic Prostate Cancer: Integration of Imaging, Liquid Biopsies and Biomarkers With Artificial Intelligence
Management of metastatic prostate cancer (mPCa) poses significant challenges due to inherent tumor heterogeneity and therapeutic resistance. Advances in molecular imaging, liquid biopsies, and biomarkers are enabling precision oncology, while artificial intelligence (AI), including machine learning…
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Value Analysis of MRI Habitat Analysis Combined Model in the Diagnosis of Ovarian Tumors
Objective This study aimed to investigate the clinical diagnostic performance of a combined classification model incorporating magnetic resonance imaging (T1WI-CE) habitat and human epididymis protein 4 (HE4) for differentiating borderline ovarian tumors (BOTs) from malignant epithelial ovarian…
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Artikel Jurnal
Role of Bioinformatics in Identifying Novel Biomarkers for Immune Cell Exhaustion and Tumor Microenvironment
This review explores the role of bioinformatics in identifying novel biomarkers for immune cell exhaustion (ICE), a dysfunction state in T cells during chronic infections and cancer. ICE, marked by upregulation of inhibitory receptors such as PD-1 and CTLA-4, impairs immune responses, a critical…
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Moderate Hypofractionated Helical Tomotherapy for Localized Prostate Cancer in Older Patients: A Single-Institution Study of Toxicity and Outcomes
Introduction The optimal management of localized prostate cancer (PCa) in the “oldest-old” demographic presents a unique clinical challenge, requiring a careful balance between oncological control and the preservation of quality of life. This study aims to evaluate the safety, toxicity profile, and…
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Dosimetric Performance Analysis of Pediatric Based Halcyon™ Volumetric Arc Therapy-Based Lung-Sparing Total Body Irradiation
Introduction Halcyon™ O-ring linear accelerators (linacs) provide a robust and efficient radiotherapy option for clinics. Interest in volumetric arc therapy (VMAT) based total body irradiation (TBI) has grown, with most current VMAT TBI protocols employing C-arm linacs; however, the feasibility of…
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Artikel Jurnal
Effect of Perioperative Glutamine-Enhanced Parenteral Nutrition on Short-Term Outcomes in Colorectal Cancer Patients Undergoing Radical Resection: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background Parenteral glutamine (Gln) supplementation can enhance the immune function of patients with colorectal cancer(CRC), regulate inflammatory response, nitrogen balance and protein synthesis, reduce the morbidity of postoperative complications and shorten the length of hospitalization…
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Effect of Cisplatin Cycles on Prognosis for Cervical Cancer Patients Treated With Concurrent Chemoradiotherapy: A Retrospective Cohort Study
Introduction To assess the impact of cisplatin cycles on overall survival (OS) and disease-free survival (DFS) in cervical cancer (CC) patients undergoing concurrent chemoradiotherapy (CCRT), and to build a nomogram-based prognostic stratification to identify CC patients who might benefit from ≥ 5…
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Influence of Interfractional Variations of Bladder and Rectal Filling on Vaginal Cuff Movement and the Role of Rectal Balloons in Gynecological Pelvic Proton Beam Therapy
Introduction Postoperative active raster-scanning intensity modulated proton beam therapy (IMPT) for gynecological cancers requires precise target coverage, yet interfractional motion of the vaginal cuff and adjacent pelvic organs may compromise dosimetric robustness. This study retrospectively…
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Focusing on the Advances and Challenges of HER2-Targeted Therapy: Cutting-Edge Breakthroughs in Neoadjuvant Treatment for HER2-Positive Breast Cancer
HER2-positive breast cancer, characterized by overexpression of the human epidermal growth factor receptor 2 (HER2), accounts for approximately 15-20% of all breast cancers and is associated with aggressive tumor behavior and poor prognosis. Advances in HER2-targeted therapies, such as monoclonal…
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Artikel Jurnal
A Hybrid CNN-Transformer Deep Learning Model for Differentiating Benign and Malignant Breast Tumors Using Multi-View Ultrasound Images
Introduction Conventional single-image analysis often fails to capture the comprehensive features of breast lesions, limiting the diagnostic accuracy of ultrasound. This study introduces a computer-aided diagnosis (CAD) system that emulates the clinical multi-view diagnostic process to improve…
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Artikel Jurnal
Hepatic Arterial Infusion Chemotherapy Plus Systemic Chemotherapy, Lenvatinib and PD-(L)1 Inhibitors Versus Systemic Chemotherapy Plus PD-(L)1 Inhibitors in Advanced Intrahepatic Cholangiocarcinoma
Introduction The prognosis for unresectable intrahepatic cholangiocarcinoma (ICC) remains poor. This retrospective study aims to evaluate the efficacy and safety of HAIC combined therapy in advanced ICC. Methods Between April 2021 and July 2024, patients with advanced ICC treated with either HAIC…
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Artikel Jurnal
RNI Precision Trial Protocol: Optimization of Regional Node Irradiation for Sentinel Lymph Node-positive Breast Cancer Omitting Axillary Dissection Based on Clinical and Genomic Risk Assessment: A Prospective Clinical Trial
Background Sentinel lymph node biopsy (SLNB) has been the standard treatment procedure for clinically node-negative (cN0) breast cancer (BC). Three randomized trials (Z0011, AMAROS and SENOMAC) have shown that patients with low-burden sentinel lymph node metastasis can be safely omitted axillary…
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Artikel Jurnal
Mechanical Microenvironment-Dependent Tumor Growth Intervention: Recent Advances and Translational Outlook
In recent years, increasing attention has been directed toward the mechanical microenvironment, which has become a major research focus in elucidating the mechanisms underlying tumor progression. On one hand, endogenous mechanical cues, such as matrix stiffness, fluid shear stress(FSS), and…
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Artikel Jurnal
Phantom-Based Dosimetric Comparison of Helical and Fixed-Beam TomoTherapy for Spatially Fractionated Radiotherapy Using GRID and Lattice Target Designs
Introduction Spatially Fractionated Radiotherapy (SFRT) delivers intentionally heterogeneous dose distributions with alternating high- and low-dose regions and has been widely applied in the management of bulky tumors. In SFRT, high-dose sub-volumes (referred to as vertices) are distributed within…
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Artikel Jurnal
Prognostic Impact of Blood Transfusions During Nivolumab Therapy in Metastatic Non-Small Cell Lung Cancer
Introduction Immune checkpoint inhibitors (ICIs) are standard therapy for metastatic non-small cell lung cancer (NSCLC). Blood transfusions, particularly erythrocyte suspension (ES) transfusions, may induce immunomodulatory effects and potentially influence cancer outcomes. This study investigated…
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Artikel Jurnal
Clinical Analysis of Rotational-Translational Error Coupling in 3DoF Versus 6DoF CBCT Couch Corrections:A Cross-Sectional Study
Introduction The 3-degree-of-freedom (3DOF) and 6-degree-of-freedom (6DOF) couches can enhance the accuracy of tumor localization in radiotherapy. However, the relationship between rotational and translational error corrections remains unclear. This study aims to evaluate the setup errors of three…
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