18.130 hasil
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PLoS Biology
Scopus
ISSN 1544-9173 · Public Library of Science (PLoS) · 18.130 artikel di indeks
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Artikel Jurnal
Targeting immunometabolism in cancer through pharmacological and lifestyle interventions.
Immunometabolism, a fundamental biogenic process that supports the function of immune cells, is often disrupted in diseases such as cancer. Tackling metabolic dysregulation at a cellular level has therefore emerged as a focus in drug development. However, as cellular metabolic rewiring takes place…
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How do immunometabolites shape bacterial infections?
Metabolites generated by host and pathogen have a major impact on the severity and outcomes of infection. The metabolic response to infection shapes the nature and intensity of the immune response, both in bloodstream infections and, especially, in the pathogenesis of pneumonia. Some metabolites…
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Artikel Jurnal
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms.
TDP-43 pathology is a hallmark of fatal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-related TDP-43-encephalopathy (LATE). In affected patients, cytoplasmic TDP-43 aggregates are accompanied by disruption of…
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Artikel Jurnal
Glucose is dynamically regulated by time of day in humans and Drosophila.
Biological clocks shape metabolism, but how circadian programs govern nutrient processing is unclear. Here, using human metabolomics and 13C6-glucose tracing in Drosophila, we delineate previously under characterized daily oscillations in glucose-derived metabolic networks, providing a mechanistic…
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Neural signaling contributes to heart formation and growth in the invertebrate chordate, Ciona robusta.
Neurons contribute to the complex interplay of signals that mediate heart development and homeostasis. Although a limited set of studies suggest that neuronal peptides impact vertebrate heart growth, the specific contributions of these peptides to cardiomyocyte progenitor differentiation or…
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Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality.
Blood levels of neurofilament light chain (NfL) increase with age in healthy humans and have been shown to predict all-cause human mortality. To determine whether this relationship is conserved across species, we analyzed NfL in the blood of various animals. We observed age-related increases in NfL…
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Sub-daily virus sampling at the Bermuda Atlantic Time Series reveals diel and depth-structured population dynamics without community-level shifts.
Ocean microbes contribute to biogeochemical cycles and ecosystem function, but they do so under top-down pressure imposed by viruses. While viruses are increasingly understood spatially and beginning to be incorporated into predictive modeling, high-frequency ocean virus dynamics remain…
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Could sleep engineering be used to combat PTSD and depression?
Sleep engineering could be developed to provide a drug-free, non-invasive avenue to treat depression and post-traumatic stress disorder. Such an intervention would be greatly aided by the sophisticated detection of memory reactivations using machine learning classifiers.
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IntAct-U-ExM enables super-resolution imaging of isoform-specific actin networks across species.
Expansion microscopy (ExM) has revolutionized super-resolution imaging in cell biology due to its simple and inexpensive workflow. The use of ExM has revealed several novel insights into the nanoscale architectures of cellular protein complexes, especially the microtubule cytoskeleton in model and…
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A cost-effective and scalable barcoded library construction method for deep mutational scanning studies.
Recent developments in DNA synthesis and sequencing allow the construction of comprehensive gene variant libraries and their functional analysis. Achieving high-replication and thorough mutation characterization remains technically and financially challenging for long genes. Here, we developed an…
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Artikel Jurnal
Could targeting viruses be a new hope against neurodegenerative diseases?
Despite decades of intensive research, our current approaches to treating neurodegenerative diseases only slow down the seemingly inevitable. Could recent data associating vaccinations with reduced risk of dementia offer an unexpected beacon of hope?
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Artikel Jurnal
A GABAergic network from AVP- to VIP-neurons in the suprachiasmatic nucleus sets the timing of circadian behavior rhythms.
The central circadian clock of the suprachiasmatic nucleus (SCN) consists of a network of multiple types of γ-aminobutyric acid (GABA)-ergic neurons and glial cells. However, the precise role of GABAergic transmission in the SCN remains unclear. In this study, we investigated the GABAergic…
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Artikel Jurnal
A bacterial ecocline in Klebsiella pneumoniae may explain its backboned phylogeny.
The genetic structure of bacterial species is most often interpreted in terms of demographic processes such as clonal descent, but can also reflect natural selection and hence give functional and ecological insight. Klebsiella pneumoniae (KP) disperses effectively around the world and has high…
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Artikel Jurnal
The Rpd3 histone deacetylase is a critical regulator of temperature-mediated morphogenesis and virulence in the human fungal pathogen Histoplasma.
Adaptive responses to environmental stimuli are integral to the survival and virulence of microbial pathogens. The thermally dimorphic human fungal pathogen Histoplasma senses temperature to transition between a mold form in soil and a pathogenic yeast in mammalian hosts. The contributions of…
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